DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src42A and frk

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	XP_002938349.1	Gene:	frk / 100488362	XenbaseID:	XB-GENE-492884	Length:	517	Species:	Xenopus tropicalis

Alignment Length:	512	Identity:	262/512 - (51%)
Similarity:	345/512 - (67%)	Gaps:	27/512 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly  1107 NCLQVVSSTTSRQPLRRWSN-------QTPLKCTCHPATEELP--LTAIEKSRSLPAACSASCSH 1162
            :||..|.....::..|..||       |.|:..|.....:..|  :...|:.|:...|..:....
Frog    10 SCLSCVLPCVFKEEKRSGSNSFNGIVIQNPVITTQLDGPQVPPRFVNQGEQQRNSYVALYSYEGR 74

  Fly  1163 TCAHLS--------VIDQSPATTKCFGKTSLTTAKKGKSRRLSEF---TRGEFLNEKSWYFRKIK 1216
            |...||        :||.:.|:   :.|..|... :||:.....|   .....:....|:|:.||
Frog    75 TPDELSFKAGDQMLIIDTTHAS---WWKAKLLRT-RGKAEGYVPFNYVAPVSSIESMPWFFKDIK 135

  Fly  1217 RIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRIRQLDEGGFFIARRTTFRTLQ 1281
            |.|||:.|:.|.|..|:||||:|||:..:|||||.||..|||||:|:||:|||:|..::.|.::.
Frog   136 RSEAERLLVRPGNTTGSFLIRESESQKGEYSLSVFDGIAVKHYRLRKLDDGGFYITSKSKFVSMN 200

  Fly  1282 ELVEHYSKDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGL 1346
            ||||:|.|..:|||..|.|||:....|:...|.:.|.|.|||:|.||||::|||.||||:|||||
Frog   201 ELVEYYGKREEGLCCKLLKPCITTGIPLPPDLCYHTADHWEINRNSLKFLKKLGQGQFGEVWEGL 265

  Fly  1347 WNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEY 1411
            ||||.||||||||:|||:|:|||.|||.||.|||.|||||.||||:|||:|||||||:|||||.|
Frog   266 WNNTIPVAIKTLKTGTMNPQDFLREAQFMKNLRHPKLIQLQAVCTLEEPVYIITELMRHGSLLSY 330

  Fly  1412 LQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIK 1476
            ||  ...|.|:.:...:|||||:|:||||||:|::|||||||||||||:..:.|:|||||||:.|
Frog   331 LQ--NDNGTSIHIPNQVDMAAQVASGMAYLETQSFIHRDLAARNVLVGENGVYKVADFGLARVFK 393

  Fly  1477 -EDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVE 1540
             ||.|||:...:.|:|||||||..|::|:||||||:||||:.|:||||::||||:|..:.|.::|
Frog   394 GEDVYEAKNDTKLPLKWTAPEAIRYNRFTIKSDVWAFGILIFEIVTYGKMPYPGLTGRQALDKLE 458

  Fly  1541 HGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFYTSDQSDYKEAQAY 1597
            :|||:|:|.||...||:||||||:..|..|||||||||||||::.:|.|.|.||..:
Frog   459 NGYRIPKPFNCPHDLYKIMLECWNAKPEERPTFETLQWKLEDYFETDPSSYLEANNF 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	49/90 (54%)
		PTKc_Frk_like	1319..1587	CDD:270653	178/268 (66%)
		Pkinase_Tyr	1328..1580	CDD:285015	168/252 (67%)
frk	XP_002938349.1	SH3_Src_like	65..117	CDD:212779	12/55 (22%)
		SH2	125..220	CDD:387587	49/94 (52%)
		PTKc_Frk_like	238..505	CDD:270653	178/268 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	361	1.000	Domainoid score	I953
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48065
Inparanoid	1	1.050	569	1.000	Inparanoid score	I1053
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		oto102859
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3556
SonicParanoid	1	1.000	-	-		X5849
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.100