DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src42A and Tyk2

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_001244276.1	Gene:	Tyk2 / 100361294	RGDID:	2320469	Length:	1186	Species:	Rattus norvegicus

Alignment Length:	334	Identity:	115/334 - (34%)
Similarity:	166/334 - (49%)	Gaps:	51/334 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly  1272 ARRTTFRT-LQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLG 1335
            |:|.:||| |::|.....::..|...      |..:.|.:        |.....:..||.:|.||
  Rat   853 AQRPSFRTILRDLTRLQPQNLVGTST------VNSDSPAS--------DPTVFHKRYLKRIRDLG 903

  Fly  1336 SGQFGDVWEGLW----NNT---TPVAIKTLKSGTMDPK---DFLAEAQIMKKLRHTKLIQLYAVC 1390
            .|.||.|  .|:    ||.   ..||:|.||.| ..|:   .:..|.:|::.|.|..:::....|
  Rat   904 EGHFGKV--SLYCYDPNNDGTGEMVAVKALKEG-CGPQLRSGWQREIEILRTLYHEHIVKYKGCC 965

  Fly  1391 --TVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAA 1453
              ..|:.:.::.|.:..|||.:||..     .|:.:..|:..|.||..|||||.:|:||||||||
  Rat   966 EDQGEKSVQLVMEYVPLGSLRDYLPR-----HSVGLAQLLLFAQQICEGMAYLHAQHYIHRDLAA 1025

  Fly  1454 RNVLVGDGNIVKIADFGLARLIKE--DEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILL 1516
            ||||:.:..:|||.|||||:.:.|  :.|..|.....|:.|.|||.....||...|||||||:.|
  Rat  1026 RNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFYYASDVWSFGVTL 1090

  Fly  1517 TELVTY---------GRIPYPGMTNAEV----LTQ-VEHGYRMPQPPNCEPRLYEIMLECWHKDP 1567
            .||:||         ..|...|:|..::    ||: :|.|.|:|:|..|...:|.:|..||..:.
  Rat  1091 YELLTYCDSSQSPPTKFIELIGVTQGQMTVLRLTELLERGERLPRPDRCPCEIYHLMKNCWESEA 1155

  Fly  1568 MRRPTFETL 1576
            ..||||:.|
  Rat  1156 SFRPTFQNL 1164

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	8/29 (28%)
		PTKc_Frk_like	1319..1587	CDD:270653	105/286 (37%)
		Pkinase_Tyr	1328..1580	CDD:285015	104/277 (38%)
Tyk2	NP_001244276.1	FERM_F1	33..130	CDD:408179
		FERM_F2	148..271	CDD:408177
		Jak1_Phl	290..433	CDD:407742
		SH2	438..536	CDD:417686
		PKc_like	591..866	CDD:419665	6/12 (50%)
		PTKc_Tyk2_rpt2	891..1173	CDD:270664	104/282 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910