DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src42A and srms

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_001129722.2	Gene:	srms / 100192213	ZFINID:	ZDB-GENE-081022-95	Length:	492	Species:	Danio rerio

Alignment Length:	386	Identity:	174/386 - (45%)
Similarity:	250/386 - (64%)	Gaps:	11/386 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly  1201 RGEFLNEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRIRQLD 1265
            :.||.|.| ||:..|.|.:|||.||..||:.|:||:|.|||..::|::|.|..::|.|:||.:..
Zfish   108 KDEFANYK-WYYGNINRQKAEKLLLSSENKTGSFLVRISESHSDEYTISARSENSVFHFRIHRSP 171

  Fly  1266 EGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKF 1330
            .|.:|::.:.:|.||.||:.:|.::|..|..::.:||||..:..       ..:.||..|.....
Zfish   172 IGAYFVSEKISFGTLDELIRYYQQNSRSLGCHIDQPCVQRRELF-------DMEPWERPREEFML 229

  Fly  1331 VRKLGSGQFGDVWEGLW-NNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEE 1394
            |:|||.|.||:|||.:| .....||||.||.......:|:.|...:|.|.|.|||:|.|:|:..|
Zfish   230 VKKLGEGHFGEVWEAIWKTQKKKVAIKMLKQEDTKLDEFVKEVHALKNLHHPKLIELLALCSRGE 294

  Fly  1395 PIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVG 1459
            |:||:||||..|||..||.  :.:|:.|....||.||||||.||||||.::.:||||||||:|||
Zfish   295 PVYIVTELMAKGSLKSYLS--SAEGQLLTSAHLIYMAAQIAEGMAYLEDRHIVHRDLAARNILVG 357

  Fly  1460 DGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGR 1524
            :..:.|:|||||||:||:..:.|....:.|::|||||||.|.:||:||||||||:||.|:::.|:
Zfish   358 NDLVCKVADFGLARIIKDSVFTASKTTKIPVRWTAPEAALYQRFSVKSDVWSFGVLLYEMMSRGK 422

  Fly  1525 IPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFYT 1585
            :||.|.||.||:..:..|||:..|.:|.|.:|.||||||:.:..:||:|..|..:|::.|:
Zfish   423 MPYDGKTNKEVMEALSSGYRLACPNHCPPNIYRIMLECWNNEASKRPSFHALHSQLDNIYS 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	35/90 (39%)
		PTKc_Frk_like	1319..1587	CDD:270653	131/268 (49%)
		Pkinase_Tyr	1328..1580	CDD:285015	126/252 (50%)
srms	NP_001129722.2	SH3	52..106	CDD:302595
		SH2	114..197	CDD:214585	34/83 (41%)
		PKc_like	220..481	CDD:304357	130/262 (50%)
		STYKc	229..478	CDD:214568	126/250 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910