Protein Alignment Src42A and btk

DIOPT Version :9

• Sequence 1: NP_610191.2
• Gene: Src42A / 35524
• FlyBaseID: FBgn0264959
• Length: 1597
• Species: Drosophila melanogaster
• Sequence 2: NP_001123732.1
• Gene: btk / 100170477
• XenbaseID: XB-GENE-6451230
• Length: 649
• Species: Xenopus tropicalis
• Alignment Length: 670
• Identity: 205/670 - (30%)
• Similarity: 316/670 - (47%)
• Gaps: 120/670 - (17%)

  Fly   998 KRTQAKRRIGVTNLLLPLDSEELY----TRIIAQQRGLDKEHSQEPEEKCASEEQMCTRNALTKS 1058
            ||:|.||:....|.     .:.|:    |:||..:...|:..                |.:...|
 Frog    14 KRSQQKRKTSPLNF-----KKRLFVLTDTKIIYYEYDFDRGR----------------RGSKKGS 57

  Fly  1059 SSLDAISLSVAISPASSPSPPR--PRR---SLKQHRCLQQ--------HQQTP---------LAK 1101
            ..||.:.....:.|..:|.|.|  |.|   ..:|...:::        :...|         |.|
 Frog    58 VDLDKVICVECVEPEENPPPERQIPNREEFDTEQMTIIERFPYPFQIVYDDGPLYVFAPTEELRK 122

  Fly  1102 K--HSLDNCLQVVSSTTSRQPLRRWSNQTPLKCT--------CHP--------ATEEL------- 1141
            :  |.|.:.::..|....:...|.:.:...|.|.        |.|        .||..
 Frog   123 RWIHQLKHVIRFNSDVAQKYHPRFYQDGQYLCCAQTAKNAMGCQPLGNANGFIRTERSQRRSRKP 187

  Fly  1142 --PLTAIEKSRSLPAACSASCSHTCAHLSVIDQSPATTKCF---------------GKTSLTTAK 1189
              |....|..:.||   ...|......:::.|.:|...:..               |...|....
 Frog   188 LPPPPPQESQKPLP---PTPCLSLHKVVAMYDFTPLNAQDLPLHKGEEYVLLEEGTGNPWLRARD 249

  Fly  1190 KGKSRRLSEFTRGEFLNEK-------SWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYS 1247
            |   ..|..:..|.::.|.       .||.:.:.|.:|| |||..|::.|.|::||| |:...|:
 Frog   250 K---NGLEGYIPGNYVTEAQDPLEIYEWYSKNMTRSQAE-KLLRAEDKEGGFIVRDS-SKAGKYT 309

  Fly  1248 LSV---RDGD-TVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEK- 1307
            :||   ..|: .::||.:.:.....:::|.:..:.::.||:.::..::.||...|..|...:.|
 Frog   310 VSVYAKSSGEGIIRHYVVCEAPGNQYYLAEKHLYSSIPELITYHQHNAAGLISRLKYPVCSLRKT 374

  Fly  1308 -PVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAE 1371
             |.|.||.:   ..||||...|.|:::||:||||.|..|.|.....||||.:|.|:|...:|:.|
 Frog   375 APSTAGLGY---GSWEIDPKDLTFLKELGNGQFGVVKYGKWRGQHDVAIKMIKEGSMSEDEFIEE 436

  Fly  1372 AQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAA 1436
            |:.|.||.|..|:|||.|||.:.||:||||.:.:|.||.||:.:.|:   :....|:.|.:.:.|
 Frog   437 AKCMMKLSHQNLVQLYGVCTKQRPIFIITEFLSNGCLLNYLKDLRGR---VSQGDLLSMCSDVCA 498

  Fly  1437 GMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYS 1501
            .|.||||:.|:||||||||.||....|||::||||:|.:.:|||.:.:|::||::|::||...|.
 Frog   499 AMTYLESKQYLHRDLAARNCLVAADGIVKVSDFGLSRYVLDDEYTSSLGSKFPVRWSSPEVLLYC 563

  Fly  1502 KFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKD 1566
            :||.||||||||:|:.|:.|.||:||...||.|::.|:..|.|:.:|.|...|:|.||:.||.:.
 Frog   564 RFSSKSDVWSFGVLMWEVFTLGRMPYDRFTNNEIVEQITRGVRLYRPQNATDRVYSIMVSCWAEK 628

  Fly  1567 PMRRPTF----ETLQWKLED 1582
            ...||||    .|:...|||
 Frog   629 ADDRPTFRILHNTILEVLED 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	27/94 (29%)
		PTKc_Frk_like	1319..1587	CDD:270653	124/268 (46%)
		Pkinase_Tyr	1328..1580	CDD:285015	117/255 (46%)
btk	NP_001123732.1	PH_Btk	8..167	CDD:269944	32/173 (18%)
		SH3_BTK	209..264	CDD:212839	7/57 (12%)
		SH2_Tec_Btk	267..370	CDD:198260	28/104 (27%)
		PKc_like	388..638	CDD:419665	118/252 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910