Protein Alignment mle and DHX38

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: NP_054722.2
• Gene: DHX38 / 9785
• HGNCID: 17211
• Length: 1227
• Species: Homo sapiens
• Alignment Length: 827
• Identity: 228/827 - (27%)
• Similarity: 374/827 - (45%)
• Gaps: 178/827 - (21%)

  Fly   274 KIDEVIKGLDLPVVNPRNIKIELDGPPIPL------IVNLSRIDS-------SQQDGEKRQESSV 325
            |:..::..|..|.::.|.:..:...|.||:      :..::|..|       .|::.:|.|..
Human   404 KVHLMVHNLVPPFLDGRIVFTKQPEPVIPVKDATSDLAIIARKGSQTVRKHREQKERKKAQHK-- 466

  Fly   326 IPWAPPQANWNTWHACNIDEGELATTSIDDL-----------------SMDY--ERSLRDRRQND 371
                    :|           |||.|.:.|:                 .:||  |:...|..:..
Human   467 --------HW-----------ELAGTKLGDIMGVKKEEEPDKAVTEDGKVDYRTEQKFADHMKRK 512

  Fly   372 NE-------YRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSG 429
            :|       .:..||.|:.|||.|::.|:||.|.||.:||:.|.||.|||||:.||:.:|    |
Human   513 SEASSEFAKKKSILEQRQYLPIFAVQQELLTIIRDNSIVIVVGETGSGKTTQLTQYLHED----G 573

  Fly   430 QGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRK- 493
            ...|..|..|||||::|:|||:||:.|....||:.|||::|||.. ......|.:.|.|:|||:
Human   574 YTDYGMIGCTQPRRVAAMSVAKRVSEEMGGNLGEEVGYAIRFEDC-TSENTLIKYMTDGILLRES 637

  Fly   494 -LEAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVL 557
             .||.|...|.||:||.|||.:|:|.|..:||::|....||.:|:.|||:|..||:.:||..|:.
Human   638 LREADLDHYSAIIMDEAHERSLNTDVLFGLLREVVARRSDLKLIVTSATMDAEKFAAFFGNVPIF 702

  Fly   558 EVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQK 622
            .:|||.|||                                         :|.::|..::.|
Human   703 HIPGRTFPV-----------------------------------------DILFSKTPQEDY--- 723

  Fly   623 TRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGW-------NLIFALMKFLQNTNIFG 680
                        |...:.::|.:|:  ...||.||:|:||.       :.|...::.|:|.....
Human   724 ------------VEAAVKQSLQVHL--SGAPGDILIFMPGQEDIEVTSDQIVEHLEELENAPALA 774

  Fly   681 DTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTS 745
                  :||.:||:|.|.|.|:|:..|:||.|.|::|||||||:|:|.|:||||....::|:|..
Human   775 ------VLPIYSQLPSDLQAKIFQKAPDGVRKCIVATNIAETSLTVDGIMFVIDSGYCKLKVFNP 833

  Fly   746 HNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQ-ALEDNLTPEMFRTPLHEMALTI 809
            ...:.:......|:.|..||.|||||..||.||.|.:::.:: .|.....||:.||.|..:.|.:
Human   834 RIGMDALQIYPISQANANQRSGRAGRTGPGQCFRLYTQSAYKNELLTTTVPEIQRTNLANVVLLL 898

  Fly   810 KLLRLGSI--HHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMM 872
            |.|.:..:  .||    ::|||.|.::.:...|..:..||....||..|||:...|::|.|.||:
Human   899 KSLGVQDLLQFHF----MDPPPEDNMLNSMYQLWILGALDNTGGLTSTGRLMVEFPLDPALSKML 959

  Fly   873 VLGAVFGCADLMAIMASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQ 937
            ::....||:..:.::.|..|. ..:|....|:...::..:.......|||:..:.....|
Human   960 IVSCDMGCSSEILLIVSMLSV-PAIFYRPKGREEESDQIREKFAVPESDHLTYLNVYLQW----- 1018

  Fly   938 RGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQA-----------GFPEECMIS---HEVDE 988
            :..:....:|:...:....|..:.:.:.||.|::.|.           ....:|:.:   |:. .
Human  1019 KNNNYSTIWCNDHFIHAKAMRKVREVRAQLKDIMVQQRMSLASCGTDWDIVRKCICAAYFHQA-A 1082

  Fly   989 RIDGDDPVLDVSLALLC----------LGLYPNICVHKEKRKVLTTE 1025
            ::.|....:::...:.|          :|..|:..|:.|  .|:||:
Human  1083 KLKGIGEYVNIRTGMPCHLHPTSSLFGMGYTPDYIVYHE--LVMTTK 1127

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684
		DEXHc_DHX9	326..559	CDD:350730	95/260 (37%)
		HrpA	378..>889	CDD:441249	180/522 (34%)
		OB_NTP_bind	1002..1079	CDD:400182	8/34 (24%)
DHX38	NP_054722.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..320
		HrpA	532..>1146	CDD:441249	202/678 (30%)
		DEAH box	652..655		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1155..1227