DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mle and DHX38

DIOPT Version :9

Sequence 1:NP_476641.1 Gene:mle / 35523 FlyBaseID:FBgn0002774 Length:1293 Species:Drosophila melanogaster
Sequence 2:NP_054722.2 Gene:DHX38 / 9785 HGNCID:17211 Length:1227 Species:Homo sapiens


Alignment Length:827 Identity:228/827 - (27%)
Similarity:374/827 - (45%) Gaps:178/827 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   274 KIDEVIKGLDLPVVNPRNIKIELDGPPIPL------IVNLSRIDS-------SQQDGEKRQESSV 325
            |:..::..|..|.::.|.:..:...|.||:      :..::|..|       .|::.:|.|..  
Human   404 KVHLMVHNLVPPFLDGRIVFTKQPEPVIPVKDATSDLAIIARKGSQTVRKHREQKERKKAQHK-- 466

  Fly   326 IPWAPPQANWNTWHACNIDEGELATTSIDDL-----------------SMDY--ERSLRDRRQND 371
                    :|           |||.|.:.|:                 .:||  |:...|..:..
Human   467 --------HW-----------ELAGTKLGDIMGVKKEEEPDKAVTEDGKVDYRTEQKFADHMKRK 512

  Fly   372 NE-------YRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSG 429
            :|       .:..||.|:.|||.|::.|:||.|.||.:||:.|.||.|||||:.||:.:|    |
Human   513 SEASSEFAKKKSILEQRQYLPIFAVQQELLTIIRDNSIVIVVGETGSGKTTQLTQYLHED----G 573

  Fly   430 QGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRK- 493
            ...|..|..|||||::|:|||:||:.|....||:.|||::|||.. ......|.:.|.|:|||: 
Human   574 YTDYGMIGCTQPRRVAAMSVAKRVSEEMGGNLGEEVGYAIRFEDC-TSENTLIKYMTDGILLRES 637

  Fly   494 -LEAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVL 557
             .||.|...|.||:||.|||.:|:|.|..:||::|....||.:|:.|||:|..||:.:||..|:.
Human   638 LREADLDHYSAIIMDEAHERSLNTDVLFGLLREVVARRSDLKLIVTSATMDAEKFAAFFGNVPIF 702

  Fly   558 EVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQK 622
            .:|||.|||                                         :|.::|..::.|   
Human   703 HIPGRTFPV-----------------------------------------DILFSKTPQEDY--- 723

  Fly   623 TRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGW-------NLIFALMKFLQNTNIFG 680
                        |...:.::|.:|:  ...||.||:|:||.       :.|...::.|:|.....
Human   724 ------------VEAAVKQSLQVHL--SGAPGDILIFMPGQEDIEVTSDQIVEHLEELENAPALA 774

  Fly   681 DTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTS 745
                  :||.:||:|.|.|.|:|:..|:||.|.|::|||||||:|:|.|:||||....::|:|..
Human   775 ------VLPIYSQLPSDLQAKIFQKAPDGVRKCIVATNIAETSLTVDGIMFVIDSGYCKLKVFNP 833

  Fly   746 HNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQ-ALEDNLTPEMFRTPLHEMALTI 809
            ...:.:......|:.|..||.|||||..||.||.|.:::.:: .|.....||:.||.|..:.|.:
Human   834 RIGMDALQIYPISQANANQRSGRAGRTGPGQCFRLYTQSAYKNELLTTTVPEIQRTNLANVVLLL 898

  Fly   810 KLLRLGSI--HHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMM 872
            |.|.:..:  .||    ::|||.|.::.:...|..:..||....||..|||:...|::|.|.||:
Human   899 KSLGVQDLLQFHF----MDPPPEDNMLNSMYQLWILGALDNTGGLTSTGRLMVEFPLDPALSKML 959

  Fly   873 VLGAVFGCADLMAIMASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQ 937
            ::....||:..:.::.|..|. ..:|....|:...::..:.......|||:..:.....|     
Human   960 IVSCDMGCSSEILLIVSMLSV-PAIFYRPKGREEESDQIREKFAVPESDHLTYLNVYLQW----- 1018

  Fly   938 RGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQA-----------GFPEECMIS---HEVDE 988
            :..:....:|:...:....|..:.:.:.||.|::.|.           ....:|:.:   |:. .
Human  1019 KNNNYSTIWCNDHFIHAKAMRKVREVRAQLKDIMVQQRMSLASCGTDWDIVRKCICAAYFHQA-A 1082

  Fly   989 RIDGDDPVLDVSLALLC----------LGLYPNICVHKEKRKVLTTE 1025
            ::.|....:::...:.|          :|..|:..|:.|  .|:||:
Human  1083 KLKGIGEYVNIRTGMPCHLHPTSSLFGMGYTPDYIVYHE--LVMTTK 1127

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mleNP_476641.1 DSRM 4..68 CDD:214634
DSRM 170..240 CDD:214634
DEXDc 393..569 CDD:214692 82/177 (46%)
DEXDc 402..542 CDD:238005 64/141 (45%)
ATP-synt_B <584..644 CDD:304375 4/59 (7%)
Helicase_C 643..772 CDD:278689 50/135 (37%)
HA2 842..926 CDD:214852 21/83 (25%)
OB_NTP_bind 974..1078 CDD:285018 11/76 (14%)
DHX38NP_054722.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 60..320
HrpA 515..1146 CDD:224557 205/695 (29%)
DEAH box 652..655 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1155..1227
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1643
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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