Protein Alignment mle and hrpB

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: NP_414690.4
• Gene: hrpB / 944845
• ECOCYCID: EG12329
• Length: 809
• Species: Escherichia coli
• Alignment Length: 638
• Identity: 173/638 - (27%)
• Similarity: 294/638 - (46%)
• Gaps: 112/638 - (17%)

  Fly   384 LPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRISAIS 448
            ||:||:..|:|||::..|.|::...||.||:|.:...:|     :..|....|.:.:|||::|.:
E. coli     4 LPVAAVLPELLTALDCAPQVLLSAPTGAGKSTWLPLQLL-----AHPGINGKIILLEPRRLAARN 63

  Fly   449 VAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRKLEAG--LRGVSHIIVDEIHE 511
            ||:|:|....|:.||||||.:|.::.. .|...:...|.|||.|.::..  |.||..:|:||.||
E. coli    64 VAQRLAELLNEKPGDTVGYRMRAQNCV-GPNTRLEVVTEGVLTRMIQRDPELSGVGLVILDEFHE 127

  Fly   512 RDVNSDFLLVILRDMVD-TYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDII 575
            |.:.:|..|.:|.|:.. ...||.:::||||:|..:..:.....||:...||:|||::.:|.
E. coli   128 RSLQADLALALLLDVQQGLRDDLKLLIMSATLDNDRLQQMLPEAPVVISEGRSFPVERRYLP--- 189

  Fly   576 QMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSFELL 640
                 :|:                                    .|:..:|:|:     .:.|:|
E. coli   190 -----LPA------------------------------------HQRFDDAVAV-----ATAEML 208

  Fly   641 EALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRKVFEP 705
                     :...|::|:||||...|..:.:  |..:..|  |...:.|.:..:..::|||...|
E. coli   209 ---------RQESGSLLLFLPGVGEIQRVQE--QLASRIG--SDVLLCPLYGALSLNDQRKAILP 260

  Fly   706 VPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAG 770
            .|:|:.|::|:|||||||:||:.|..|:|..:.|:..|.....||...|...|:.::.||.||||
E. coli   261 APQGMRKVVLATNIAETSLTIEGIRLVVDCAQERVARFDPRTGLTRLITQRVSQASMTQRAGRAG 325

  Fly   771 RVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVDAVIE 835
            |:.||....|.::.:.:.......||:.::.|  ..|.::||:.|.........|:.|||..::.
E. coli   326 RLEPGISLHLIAKEQAERAAAQSEPEILQSDL--SGLLMELLQWGCSDPAQMSWLDQPPVVNLLA 388

  Fly   836 AEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEVFSL 900
            |:.||:.:..|: .:.|:..|:.:|.|..:|||..|:|.......|...|.:|:.......:.:.
E. coli   389 AKRLLQMLGALE-GERLSAQGQKMAALGNDPRLAAMLVSAKNDDEAATAAKIAAILEEPPRMGNS 452

  Fly   901 DIG----------QRRLANHQKALS---GTKCSDHVAMIV----ASQMWRREKQRGEHMEARFCD 948
            |:|          |:|.....|.|:   |...|..:|.::    |.::.||..|.|.:..|
E. coli   453 DLGVAFSRNQPAWQQRSQQLLKRLNVRGGEADSSLIAPLLAGAFADRIARRRGQDGRYQLA---- 513

  Fly   949 WKGLQMSTMNVIWDAKQQLLD--------LLQQAGFPEECMISH---EVDERI 990
                  :.|..:.||...|..        |||.:..|:..::..   ::||.:
E. coli   514 ------NGMGAMLDANDALSRHEWLIAPLLLQGSASPDARILLALLVDIDELV 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684
		DEXHc_DHX9	326..559	CDD:350730	62/177 (35%)
		HrpA	378..>889	CDD:441249	147/507 (29%)
		OB_NTP_bind	1002..1079	CDD:400182
hrpB	NP_414690.4	PRK11664	1..809	CDD:236950	173/638 (27%)