DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and Dqx1

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_291084.1	Gene:	Dqx1 / 93838	MGIID:	2136388	Length:	718	Species:	Mus musculus

Alignment Length:	905	Identity:	215/905 - (23%)
Similarity:	332/905 - (36%)	Gaps:	256/905 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   345 EGELATTSIDDLSMDYERSLRDRRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNP--VVIIRG 407
            |.|||....|.|..            .:.|.:.||.|..|||.|.|...|..:..:|  ||::.|
Mouse    15 ESELAVNPFDGLPF------------SSCYYELLEQRRALPIWAARFLFLEHLESSPTGVVLVSG 67

  Fly   408 NTGCGKTTQIAQYILDDYICSG-QGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRF 471
            :.|.||:|||.|:..:..:..| |.|  .:.||||..::|:|:|.|||.|....||..:|||:..
Mouse    68 DPGSGKSTQIPQWCAEFALARGFQTG--QVTVTQPYPLAAMSLASRVADEMDLTLGHEIGYSIPQ 130

  Fly   472 ESVFPRPYGAILFCTVGVLLRKLEAGLRGV---SHIIVDEIHERDVNSDFLLVILRD-MVDTYP- 531
            |.. ..|...:.||...:.|::: |..||.   |.:|:||..||.|.||.|..:||| .:...|
Mouse   131 EDC-TGPNTMLRFCWDRLFLQEV-ASTRGPGAWSVLILDEAQERSVASDLLQGLLRDTRLRNLPG 193

  Fly   532 DLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDE 596
            |..|::::......||..::|..|::.||...........:|.:. ||.|.:|
Mouse   194 DPRVVVVTDPALEPKFQAFWGNSPIVRVPREPGGDPTLAYKDTVP-TDLVEAA------------ 245

  Fly   597 EQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLP 661
                              |                         :|:|...:.:..||.:||:||
Mouse   246 ------------------C-------------------------QAVLELCQQEEAPGDVLVYLP 267

  Fly   662 GWNLIFALMKFLQNTNIFGDTSQY-------QILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNI 719
            ....|....:.|.     |:....       ::||.|....:..| .|:|.....|.||:::..:
Mouse   268 SEEEISLCCESLS-----GEMGTLAVPGPPPRVLPLHPGCAQAIQ-TVYEDTDVSVRKIVVTHWL 326

  Fly   720 AETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRA 784
            |:.|.::..|..|||.......::.......|......||...|.|..||....||.|..|.|::
Mouse   327 ADFSFSLPSIQHVIDSGLELRSVYNPRIRAESQVLRPISKCQAEARLLRAKGFPPGSCLRLYSKS 391

  Fly   785 RFQ----------ALEDNLTPEMFRTPLHEMALTIKLLRLGSIH----HFLSKALEPPPVDAVIE 835
            ..:          ..|:||:           :|.:.|:|.....    |||.:   |.|
Mouse   392 TLELEAPPLPHPKVCEENLS-----------SLVLLLMRKQIAEPGECHFLDR---PAP------ 436

  Fly   836 AEVLLREMRCLD----AND--ELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTF 894
             |.|:|.:..||    .||  ||:.||.:|:..|:.|.|.|.::....|.|.|.|..:|: ..|.
Mouse   437 -EALMRALEDLDYLAALNDDGELSDLGVILSEFPLPPELAKALLASCEFNCVDEMLTLAA-MLTA 499

  Fly   895 SEVFS---LDIGQ---RRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQ 953
            :..|:   |..|:   ||...|..       .||.::|   |::....|.|  .:..:|..:||.
Mouse   500 APGFTRPPLSAGEAALRRALEHAD-------GDHSSLI---QVYEAFVQSG--ADEAWCQARGLN 552

  Fly   954 MSTMNVIWDAKQQLLDLLQQAGFP-EECMISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKE 1017
            ..::......:.:|::|:|:...| .:.....|.:.|        |:..|||. |.:..:.
Mouse   553 WESLCQARKLRAELVELMQRIELPLSQPAFGSEQNRR--------DLQKALLS-GYFLKVA---- 604

  Fly  1018 KRKVLTTESKAALLHKTSVNCSNLAVTFPYPFFVFGEKIRTRAVSCKQLSMVSPLQV---ILFGS 1079
             |....|.:...|.||      ::|...||               |...:..:|.|.   :|:.|
Mouse   605 -RDTDGTGNYLLLTHK------HVAQLSPY---------------CSYRNRRTPAQPPTWVLYHS 647

  Fly  1080 RKIDLAANNIVRVDNWLNF--DIEPELAAKIGALKPALEDLITVACDNPSDILRLEEPYAQLVKV 1142
            ..|.        .||.|..  :|:||:                        ::.|..||..
Mouse   648 FSIS--------KDNCLCIVSEIQPEM------------------------LVELAPPYFL---- 676

  Fly  1143 VKDLCVKSAGDFGLQRESGILPHQSR----QFSDGGGPPKRGRFETGRFTNSSFGRRGNG 1198
                             |.:.|.:||    |..:|...|.....||     ||....|:|
Mouse   677 -----------------SNLPPSESRDLLNQLREGTAEPPAAATET-----SSPQEYGDG 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634
		DEXDc	393..569	CDD:214692	61/183 (33%)
		DEXDc	402..542	CDD:238005	53/145 (37%)
		ATP-synt_B	<584..644	CDD:304375	3/59 (5%)
		Helicase_C	643..772	CDD:278689	32/135 (24%)
		HA2	842..926	CDD:214852	27/95 (28%)
		OB_NTP_bind	974..1078	CDD:285018	20/107 (19%)
Dqx1	NP_291084.1	HrpA	9..672	CDD:224557	200/835 (24%)
		DEAQ box	167..170		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	690..718		9/30 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900