DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and DHX57

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_945314.1	Gene:	DHX57 / 90957	HGNCID:	20086	Length:	1386	Species:	Homo sapiens

Alignment Length:	1108	Identity:	359/1108 - (32%)
Similarity:	540/1108 - (48%)	Gaps:	193/1108 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 VIDRIQEQRDMNEAEAFDVNAAIHGNWTIENAKERLNIYKQTNNIRDDYKYTPVGPEHA------ 197
            ::.||:...|.:...|            ||:|.   .:|:.......|:||....|..|
Human   330 IVGRIERSVDDSHLNA------------IEDAS---FLYELEIRFSKDHKYPYQAPLVAFYSTNE 379

  Fly   198 ------RSFLAELSIYVPALNRTVTARESGSNKKSASKSCALSLVRQL-FHLNVIEPFSGTLKKK 255
                  |..::|. :|..||....|           |:....||:..| ....:::..:.|..|.
Human   380 NLPLACRLHISEF-LYDKALTFAET-----------SEPVVYSLITLLEEESEIVKLLTNTHHKY 432

  Fly   256 KDEQLKPYPV-------------KLSPN---LINKIDEVIKGLDLPVVNPRNIKIELDGPPIPLI 304
            .|..:...||             .:.||   :.|:|.||.|..:       :.:.:.|..|.|:|
Human   433 SDPPVNFLPVPSRTRINNPACHKTVIPNNSFVSNQIPEVEKASE-------SEESDEDDGPAPVI 490

  Fly   305 ------VNLSRIDSSQQDGEKRQESSVIPWAPPQANWNTWHACNI--DEGELATTSIDDLSMDYE 361
                  |||.:..|.:.|                     |.|.::  :.|::.
Human   491 VENESYVNLKKKISKRYD---------------------WQAKSVHAENGKIC------------ 522

  Fly   362 RSLRDRRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYI 426
            :..| .:|...:::..|:.|:.||....|..||..:..:.||:|.|.|||||||||.|:||||.:
Human   523 KQFR-MKQASRQFQSILQERQSLPAWEERETILNLLRKHQVVVISGMTGCGKTTQIPQFILDDSL 586

  Fly   427 CSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLL 491
            .......|||..||||||||||||||||:||.|::|.||||.:|.||| ......:|:||.||||
Human   587 NGPPEKVANIICTQPRRISAISVAERVAKERAERVGLTVGYQIRLESV-KSSATRLLYCTTGVLL 650

  Fly   492 RKLE--AGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGIC 554
            |:||  ..|:|||||||||:|||...|||||::|:|:|...|.|.|||||||::...||.||..|
Human   651 RRLEGDTALQGVSHIIVDEVHERTEESDFLLLVLKDIVSQRPGLQVILMSATLNAELFSDYFNSC 715

  Fly   555 PVLEVPGRAFPVQQFFLEDIIQMTDFV----------------PSAESRRKRKEVEDEEQ----- 598
            ||:.:|||.|||.||||||.|.:|.:|                ...::||.|...|:.|:
Human   716 PVITIPGRTFPVDQFFLEDAIAVTRYVLQDGSPYMRSMKQISKEKLKARRNRTAFEEVEEDLRLS 780

  Fly   599 LLSEDKD-------EAEINYNKVCEDKY---SQKTRNAMAMLSESDVSFELLEALLMHI---KSK 650
            |..:|:|       :.::::.::.. :|   |:.....|:::....|:.||:||||..|   |..
Human   781 LHLQDQDSVKDAVPDQQLDFKQLLA-RYKGVSKSVIKTMSIMDFEKVNLELIEALLEWIVDGKHS 844

  Fly   651 NIPGAILVFLPGWNLIFALMKFLQNTNIFGD--TSQYQILPCHSQIPRDEQRKVFEPVPEGVTKI 713
            ..||||||||||...|..|.:.||:.::|.:  :::..|.|.||.:..:||:.||...|.|||||
Human   845 YPPGAILVFLPGLAEIKMLYEQLQSNSLFNNRRSNRCVIHPLHSSLSSEEQQAVFVKPPAGVTKI 909

  Fly   714 ILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCF 778
            |:|||||||||||||:|:|||..|.:.|.:.:...:.|....:.|:.|..|||||||||..|.||
Human   910 IISTNIAETSITIDDVVYVIDSGKMKEKRYDASKGMESLEDTFVSQANALQRKGRAGRVASGVCF 974

  Fly   779 TLCSRARF--QALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHF---LSKALEPPPVDAVIEAEV 838
            .|.:...:  |.|:..| ||:.|.||.::.|.||:|.:.|.|:.   .|:.:|||..|::..:::
Human   975 HLFTSHHYNHQLLKQQL-PEIQRVPLEQLCLRIKILEMFSAHNLQSVFSRLIEPPHTDSLRASKI 1038

  Fly   839 LLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEVFSLDIG 903
            .||::..|..::.|||||..||.||::.|:||:|:.|::|.|.| .|:..:.|..|...|.....
Human  1039 RLRDLGALTPDERLTPLGYHLASLPVDVRIGKLMLFGSIFRCLD-PALTIAASLAFKSPFVSPWD 1102

  Fly   904 QRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLL 968
            ::..||.:|.......||::|::.|.:.|:...:.|......:|....|....:..:...|:|..
Human  1103 KKEEANQKKLEFAFANSDYLALLQAYKGWQLSTKEGVRASYNYCRQNFLSGRVLQEMASLKRQFT 1167

  Fly   969 DLLQQAGFPEECMISHEVDERIDGDDPVLDVS--------------LALLCLGLYPNICVHKE-- 1017
            :||...||..|.:.:.|:::|..|.|.|||.:              .|:||..||||:...|.
Human  1168 ELLSDIGFAREGLRAREIEKRAQGGDGVLDATGEEANSNAENPKLISAMLCAALYPNVVQVKSPE 1232

  Fly  1018 ------------------KRKVLTTESKAALLHKTSVNCSNLAVTFPYPFFVFGEKIRTRAVSCK 1064
                              :.|.:|.......:|.:|||..  ...|..|:.::.|||:|..|..:
Human  1233 GKFQKTSTGAVRMQPKSAELKFVTKNDGYVHIHPSSVNYQ--VRHFDSPYLLYHEKIKTSRVFIR 1295

  Fly  1065 QLSMVSPLQVILFGSRKIDLAANN---IVRVDN-WLNF-DIEPELAAKIGALKPALEDLITVACD 1124
            ..||||...::|||..::::....   :|.:|: |:.| ....::|..:..|:..|:.|:.....
Human  1296 DCSMVSVYPLVLFGGGQVNVQLQRGEFVVSLDDGWIRFVAASHQVAELVKELRCELDQLLQDKIK 1360

  Fly  1125 NPS 1127
            |||
Human  1361 NPS 1363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634	17/82 (21%)
		DEXDc	393..569	CDD:214692	104/177 (59%)
		DEXDc	402..542	CDD:238005	88/141 (62%)
		ATP-synt_B	<584..644	CDD:304375	16/74 (22%)
		Helicase_C	643..772	CDD:278689	63/133 (47%)
		HA2	842..926	CDD:214852	28/83 (34%)
		OB_NTP_bind	974..1078	CDD:285018	36/137 (26%)
DHX57	NP_945314.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..106
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..147
		UBA_DHX57	181..218	CDD:270502
		RWD	243..418	CDD:283440	23/114 (20%)
		ZnF_C3H1	303..323	CDD:214632
		DEXDc	550..730	CDD:214692	105/180 (58%)
		DEXDc	561..703	CDD:238005	88/142 (62%)
		DEVH box	668..671		2/2 (100%)
		Helicase_C	832..968	CDD:278689	65/135 (48%)
		HA2	1043..1125	CDD:214852	28/82 (34%)
		OB_NTP_bind	1164..1310	CDD:285018	40/147 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820