DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and PRP22

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_010929.3	Gene:	PRP22 / 856732	SGDID:	S000000815	Length:	1145	Species:	Saccharomyces cerevisiae

Alignment Length:	939	Identity:	247/939 - (26%)
Similarity:	394/939 - (41%)	Gaps:	226/939 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 GNRYSVIDRIQEQRDMNEAEAFDVNAAIHGNWTI--------ENAKERL---NIYKQTNNIRDDY 187
            |.|....|.:....:|::....|.:..:.....|        .|.|..|   ||.:.:..||.
Yeast   199 GTRMKNCDGLVHISEMSDQRTLDPHDVVRQGQHIFVEVIKIQNNGKISLSMKNIDQHSGEIRK-- 261

  Fly   188 KYTPVGPEHARSFLAELSIYVPALNRTVTARESGSNKKSASKSCALSL-----VRQLFHLNVIEP 247
            :.|....:..||            |...|:|    |.|:..|..||:.     :|||.
Yeast   262 RNTESVEDRGRS------------NDAHTSR----NMKNKIKRRALTSPERWEIRQLI------- 303

  Fly   248 FSGTLK-----KKKDEQLKPYPVKLS--------PNLIN----KIDEVIKGLDLPVVNPRNIKIE 295
            .||...     :.|||    .|:..|        .:::|    |:|..::.......:  .|.:|
Yeast   304 ASGAASIDDYPELKDE----IPINTSYLTAKRDDGSIVNGNTEKVDSKLEEQQRDETD--EIDVE 362

  Fly   296 L---DGPPIPLIVNLSRIDSSQQDGEKRQESSVIPWAPPQANWNTWHACNIDEGELATTSID--D 355
            |   |||..        :...|..|.|:.|...|...|              .|.:..::|:  :
Yeast   363 LNTDDGPKF--------LKDQQVKGAKKYEMPKITKVP--------------RGFMNRSAINGSN 405

  Fly   356 LSMDY-ERSLRDRRQNDNEYRQFLEF--------------------------------------- 380
            ...|: |..||.:|:.:.:.|:...|
Yeast   406 AIRDHREEKLRKKREIEQQIRKQQSFDDPTKNKKDSRNEIQMLKNQLIVTEWEKNRMNESISYGK 470

  Fly   381 ---------REKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYANI 436
                     |:.||:.|||||::.|:.||..::|.|.||.||||||.|| ||:   .|...|..|
Yeast   471 RTSLPISAQRQTLPVYAMRSELIQAVRDNQFLVIVGETGSGKTTQITQY-LDE---EGFSNYGMI 531

  Fly   437 YVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRK--LEAGLR 499
            ..|||||::|:|||:|||.|...::|..|||::|||.| ..|...|.:.|.|:|.|:  |:..:.
Yeast   532 GCTQPRRVAAVSVAKRVAEEVGCKVGHDVGYTIRFEDV-TGPDTRIKYMTDGMLQREALLDPEMS 595

  Fly   500 GVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAF 564
            ..|.|::||.|||.|.:|.|..:|:......|:|.||:.|||:::.|||:||..||::.:||:.|
Yeast   596 KYSVIMLDEAHERTVATDVLFALLKKAAIKRPELKVIVTSATLNSAKFSEYFLNCPIINIPGKTF 660

  Fly   565 PVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAM 629
            ||                                                 |..|||..:
Yeast   661 PV-------------------------------------------------EVLYSQTPQ----- 671

  Fly   630 LSESDVSFELLEALL-----MHIKSKNIPGAILVFLPGWNLIFALMKFL-QNTNIFGDT-SQYQI 687
                   .:.:||.|     :||...  ||.|||||.|...|.:..:.| ......||: .:..|
Yeast   672 -------MDYIEAALDCVIDIHINEG--PGDILVFLTGQEEIDSCCEILYDRVKTLGDSIGELLI 727

  Fly   688 LPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSY 752
            ||.:|.:|.:.|.|:|||.|:|..|::.:|||||||||||.|.:|:|...|::.::.:...:...
Yeast   728 LPVYSALPSEIQSKIFEPTPKGSRKVVFATNIAETSITIDGIYYVVDPGFAKINIYNARAGIEQL 792

  Fly   753 ATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARF-QALEDNLTPEMFRTPLHEMALTIKLLRLGS 816
            .....|:....||||||||..||.|:.|.:.:.| ..:.:|..||:.|..|....|.:|.:.:..
Yeast   793 IVSPISQAQANQRKGRAGRTGPGKCYRLYTESAFYNEMLENTVPEIQRQNLSHTILMLKAMGIND 857

  Fly   817 IHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCA 881
            :..|  ..::|||.:.::.|...|..::.||...:||.||:.::..|::|.|.:.::......|:
Yeast   858 LLKF--DFMDPPPKNLMLNALTELYHLQSLDDEGKLTNLGKEMSLFPMDPTLSRSLLSSVDNQCS 920

  Fly   882 DLMAIMASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARF 946
            |.:..:.|..|. ..||.....::..|:.:||.......||:.::.....|::.....::.:..|
Yeast   921 DEIVTIISMLSV-QNVFYRPKDRQLEADSKKAKFHHPYGDHLTLLNVYTRWQQANYSEQYCKTNF 984

  Fly   947 CDWKGLQMSTMNVIWDAKQQLLDLLQQAG 975
            ..::.|:.:.     |.|.|:..:.::.|
Yeast   985 LHFRHLKRAR-----DVKSQISMIFKKIG 1008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634	19/77 (25%)
		DEXDc	393..569	CDD:214692	78/177 (44%)
		DEXDc	402..542	CDD:238005	62/141 (44%)
		ATP-synt_B	<584..644	CDD:304375	6/59 (10%)
		Helicase_C	643..772	CDD:278689	51/135 (38%)
		HA2	842..926	CDD:214852	20/83 (24%)
		OB_NTP_bind	974..1078	CDD:285018	1/2 (50%)
PRP22	NP_010929.3	Pnp	1..423	CDD:224106	56/276 (20%)
PRP22	NP_010929.3	HrpA	456..1145	CDD:224557	189/629 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810