DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and DHR2

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_012845.1	Gene:	DHR2 / 853784	SGDID:	S000001561	Length:	735	Species:	Saccharomyces cerevisiae

Alignment Length:	797	Identity:	215/797 - (26%)
Similarity:	356/797 - (44%)	Gaps:	126/797 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 SRIDSSQQDGEKRQESSVIPWAPPQANWNTWHACNI----DEGELATTSIDDLSMDYERSLRDRR 368
            ||:.|:....:::...::.|:.   .|.....|..|    |.||          .|:....|..:
Yeast     7 SRVASNHTSKKQKVRRNIHPFT---NNTRIKRASKIVKFNDSGE----------GDHVSDQRSNK 58

  Fly   369 QNDNEYR-------QFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYI 426
            :|...|:       ..|:.||.||:...:.||::.|..|||.::.|.||.||:|||.|::|:...
Yeast    59 ENVLTYKSLKSRASDLLKMRETLPVYQHKREIMSYIESNPVTVLIGETGSGKSTQIPQFVLEKLY 123

  Fly   427 CSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLL 491
            .:.:.|  :|.||||||::||::|.|||:|...:||:.|||||||::. ......:.:.|.|:||
Yeast   124 DTKKHG--SIAVTQPRRVAAINLATRVAQEHGCKLGEQVGYSVRFDNT-TTTRTRLKYLTDGMLL 185

  Fly   492 RKL--EAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVD-TYPDLHVILMSATIDTTKFSKYFGI 553
            |:|  .:.||..|.|::||.|||.|.:|.:|..|:.::. ..|||.:|:||||:...|||::|..
Yeast   186 RELMMNSDLREYSVIVIDEAHERTVLTDLILGFLKSLIQGPRPDLRIIVMSATLQAEKFSEFFNN 250

  Fly   554 CPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDK 618
            .|:|.|.||.|.|:|::|:   ..||.:..|..|                           |
Yeast   251 APILFVEGRKFDVKQYYLK---APTDDIVDAVIR---------------------------C--- 282

  Fly   619 YSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQN-TNIFGDT 682
                                     .:.|......|.||.||||...|...:..::. .....|.
Yeast   283 -------------------------CIQINQGEELGDILCFLPGQEEIDKAVTIMEKIAKYVSDE 322

  Fly   683 SQYQIL---PCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFT 744
            :...::   |.::.:|..:|..||.|:.....|::.||||||||:||..:.||:|....::|::.
Yeast   323 APVPLIVPYPLYAALPAVQQSLVFAPIKGFKRKVVFSTNIAETSVTISGVKFVVDSGLRKVKVWR 387

  Fly   745 SHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTI 809
            ....|.:..||..|:.:..||.|||||...|..|.|...:.:..|.....||:.|:.:....|.:
Yeast   388 HQLGLATLLTVPISQASAMQRSGRAGRESEGKSFRLYCESDYVKLPKQSEPEIARSDVTSPVLML 452

  Fly   810 KLLRLGSIHHFLSKA-LEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMV 873
            |  |.| :...|:.. .|.|..:|::.....|.|:..||...::|..|:.:|.||::|.|..:::
Yeast   453 K--RYG-VDDLLNWTWFENPGKEAIVMGLQELYELGALDTRGKITKRGQQMALLPLQPHLSSVLI 514

  Fly   874 LGAVFGCADLMAIMASYSSTFSEVFSL------DIGQRRLANHQKALSGTKCSDHVAMIVASQMW 932
            ..:..||...:..:.|..|..:.:.:.      ::.:|||:   ...:|.:..|.:.:.....::
Yeast   515 KASEVGCLSQVIDIVSCLSVENLLLNPSPEERDEVNERRLS---LCNAGKRYGDLIMLKELFDIY 576

  Fly   933 RREKQRGEHMEARFCDW-KGLQMST---MNVIWDAKQQLLDLLQQ--AGFPEECMISHEVDERID 991
            ..|..:.:...:...|| |||.:|.   .||| ..:.||....::  :...||    .|..::|.
Yeast   577 FYELGKSQDASSERNDWCKGLCISIRGFKNVI-RVRDQLRVYCKRLFSSISEE----DEESKKIG 636

  Fly   992 GDDPVLDVSLALLCLGLYPNICVHKEKRKVLTTESKAAL-LHKTSV-----NCSNLAVTFPYPFF 1050
            .|..::...|.....|...|..:....|...|..:...: :|.:|:     :|..:.    |..:
Yeast   637 EDGELISKILKCFLTGFIKNTAIGMPDRSYRTVSTGEPISIHPSSMLFMNKSCPGIM----YTEY 697

  Fly  1051 VFGEKIRTRAVSCKQLS 1067
            ||..|...|.||..:||
Yeast   698 VFTTKGYARNVSRIELS 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634
		DEXDc	393..569	CDD:214692	77/178 (43%)
		DEXDc	402..542	CDD:238005	61/142 (43%)
		ATP-synt_B	<584..644	CDD:304375	3/59 (5%)
		Helicase_C	643..772	CDD:278689	41/132 (31%)
		HA2	842..926	CDD:214852	19/89 (21%)
		OB_NTP_bind	974..1078	CDD:285018	22/100 (22%)
DHR2	NP_012845.1	HrpA	30..730	CDD:224557	211/771 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810