Protein Alignment mle and DHR2

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: NP_012845.1
• Gene: DHR2 / 853784
• SGDID: S000001561
• Length: 735
• Species: Saccharomyces cerevisiae
• Alignment Length: 797
• Identity: 215/797 - (26%)
• Similarity: 356/797 - (44%)
• Gaps: 126/797 - (15%)

  Fly   308 SRIDSSQQDGEKRQESSVIPWAPPQANWNTWHACNI----DEGELATTSIDDLSMDYERSLRDRR 368
            ||:.|:....:::...::.|:.   .|.....|..|    |.||          .|:....|..:
Yeast     7 SRVASNHTSKKQKVRRNIHPFT---NNTRIKRASKIVKFNDSGE----------GDHVSDQRSNK 58

  Fly   369 QNDNEYR-------QFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYI 426
            :|...|:       ..|:.||.||:...:.||::.|..|||.::.|.||.||:|||.|::|:...
Yeast    59 ENVLTYKSLKSRASDLLKMRETLPVYQHKREIMSYIESNPVTVLIGETGSGKSTQIPQFVLEKLY 123

  Fly   427 CSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLL 491
            .:.:.|  :|.||||||::||::|.|||:|...:||:.|||||||::. ......:.:.|.|:||
Yeast   124 DTKKHG--SIAVTQPRRVAAINLATRVAQEHGCKLGEQVGYSVRFDNT-TTTRTRLKYLTDGMLL 185

  Fly   492 RKL--EAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVD-TYPDLHVILMSATIDTTKFSKYFGI 553
            |:|  .:.||..|.|::||.|||.|.:|.:|..|:.::. ..|||.:|:||||:...|||::|..
Yeast   186 RELMMNSDLREYSVIVIDEAHERTVLTDLILGFLKSLIQGPRPDLRIIVMSATLQAEKFSEFFNN 250

  Fly   554 CPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDK 618
            .|:|.|.||.|.|:|::|:   ..||.:..|..|                           |
Yeast   251 APILFVEGRKFDVKQYYLK---APTDDIVDAVIR---------------------------C--- 282

  Fly   619 YSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQN-TNIFGDT 682
                                     .:.|......|.||.||||...|...:..::. .....|.
Yeast   283 -------------------------CIQINQGEELGDILCFLPGQEEIDKAVTIMEKIAKYVSDE 322

  Fly   683 SQYQIL---PCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFT 744
            :...::   |.::.:|..:|..||.|:.....|::.||||||||:||..:.||:|....::|::.
Yeast   323 APVPLIVPYPLYAALPAVQQSLVFAPIKGFKRKVVFSTNIAETSVTISGVKFVVDSGLRKVKVWR 387

  Fly   745 SHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTI 809
            ....|.:..||..|:.:..||.|||||...|..|.|...:.:..|.....||:.|:.:....|.:
Yeast   388 HQLGLATLLTVPISQASAMQRSGRAGRESEGKSFRLYCESDYVKLPKQSEPEIARSDVTSPVLML 452

  Fly   810 KLLRLGSIHHFLSKA-LEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMV 873
            |  |.| :...|:.. .|.|..:|::.....|.|:..||...::|..|:.:|.||::|.|..:::
Yeast   453 K--RYG-VDDLLNWTWFENPGKEAIVMGLQELYELGALDTRGKITKRGQQMALLPLQPHLSSVLI 514

  Fly   874 LGAVFGCADLMAIMASYSSTFSEVFSL------DIGQRRLANHQKALSGTKCSDHVAMIVASQMW 932
            ..:..||...:..:.|..|..:.:.:.      ::.:|||:   ...:|.:..|.:.:.....::
Yeast   515 KASEVGCLSQVIDIVSCLSVENLLLNPSPEERDEVNERRLS---LCNAGKRYGDLIMLKELFDIY 576

  Fly   933 RREKQRGEHMEARFCDW-KGLQMST---MNVIWDAKQQLLDLLQQ--AGFPEECMISHEVDERID 991
            ..|..:.:...:...|| |||.:|.   .||| ..:.||....::  :...||    .|..::|.
Yeast   577 FYELGKSQDASSERNDWCKGLCISIRGFKNVI-RVRDQLRVYCKRLFSSISEE----DEESKKIG 636

  Fly   992 GDDPVLDVSLALLCLGLYPNICVHKEKRKVLTTESKAAL-LHKTSV-----NCSNLAVTFPYPFF 1050
            .|..::...|.....|...|..:....|...|..:...: :|.:|:     :|..:.    |..:
Yeast   637 EDGELISKILKCFLTGFIKNTAIGMPDRSYRTVSTGEPISIHPSSMLFMNKSCPGIM----YTEY 697

  Fly  1051 VFGEKIRTRAVSCKQLS 1067
            ||..|...|.||..:||
Yeast   698 VFTTKGYARNVSRIELS 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684
		DEXHc_DHX9	326..559	CDD:350730	89/246 (36%)
		HrpA	378..>889	CDD:441249	160/518 (31%)
		OB_NTP_bind	1002..1079	CDD:400182	16/72 (22%)
DHR2	NP_012845.1	HrpA	79..>534	CDD:441249	159/518 (31%)
		OB_NTP_bind	645..722	CDD:400182	17/74 (23%)