DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and DHX16

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_003578.2	Gene:	DHX16 / 8449	HGNCID:	2739	Length:	1041	Species:	Homo sapiens

Alignment Length:	983	Identity:	256/983 - (26%)
Similarity:	416/983 - (42%)	Gaps:	188/983 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 KNRQRFLCEVRVEPN--TYIGVGNSTNKKDAEKNACRDFVNYLVRVGKLNTNDVPADAGASGGGP 90
            |||...|.|...|.:  |....|:|..||..::...|          |....:...:|..
Human    93 KNRSYRLLEDSEESSEETVSRAGSSLQKKRKKRKHLR----------KKREEEEEEEASE----- 142

  Fly    91 RTGLEGAGMAGGSGQQKRVFDGQSGPQDLGEAYRPLNHDGGDGGNRYSVIDRIQEQRDMNEAEAF 155
                :|....|||.||..               :|.:.|..:...|    :|:|   |:.|.:||
Human   143 ----KGKKKTGGSKQQTE---------------KPESEDEWERTER----ERLQ---DLEERDAF 181

  Fly   156 DVNAAIHGNWTIENAKERLNIYKQTNNI--RDDYKYTPVGPEHARSFLAELSIYVPALNRTVTAR 218
                       .|..::|..  .:|.|:  |.|.|......:..:....:....||.|.:.....
Human   182 -----------AERVRQRDK--DRTRNVLERSDKKAYEEAQKRLKMAEEDRKAMVPELRKKSRRE 233

  Fly   219 ESGSNKKSASKSCALSLVRQLFHLNVIEPFSGTLKKKKDEQLKPYPVKLSPNLINKIDEVIKGLD 283
            .....::...:.....|..:.|....:|     |.:.:.::|| |..::. :|..:.....:...
Human   234 YLAKREREKLEDLEAELADEEFLFGDVE-----LSRHERQELK-YKRRVR-DLAREYRAAGEQEK 291

  Fly   284 LPVVNPRNIKIELDGPPIPLIVNLSRIDSSQQDGEKRQESSVIPWAPPQANWNTWHACNIDEGEL 348
            |...|..::..|..|.| ...|:|...:|.....|:|:                |....:....|
Human   292 LEATNRYHMPKETRGQP-ARAVDLVEEESGAPGEEQRR----------------WEEARLGAASL 339

  Fly   349 ATTSIDDLSMD--YERSLRDRR----------QNDNE-----------YRQFLE-FREKLPIAAM 389
            ...:.|..|.:  |:..|.:..          |.|.|           .::.:: .|..||:...
Human   340 KFGARDAASQEPKYQLVLEEEETIEFVRATQLQGDEEPSAPPTSTQAQQKESIQAVRRSLPVFPF 404

  Fly   390 RSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYAN----IYVTQPRRISAISVA 450
            |.|:|.||.::.|:||.|.||.||||||.||:.::       ||.|    |..|||||::|:|||
Human   405 REELLAAIANHQVLIIEGETGSGKTTQIPQYLFEE-------GYTNKGMKIACTQPRRVAAMSVA 462

  Fly   451 ERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRKL--EAGLRGVSHIIVDEIHERD 513
            .|||||...:||:.||||:|||.. ......:.:.|.|:|||:.  |..|...|.::|||.|||.
Human   463 ARVAREMGVKLGNEVGYSIRFEDC-TSERTVLRYMTDGMLLREFLSEPDLASYSVVMVDEAHERT 526

  Fly   514 VNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMT 578
            :::|.|..:::|:....|:|.|::.|||:||.:||.:|...||..:|||.|||..|:.:
Human   527 LHTDILFGLIKDVARFRPELKVLVASATMDTARFSTFFDDAPVFRIPGRRFPVDIFYTK------ 585

  Fly   579 DFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSFELLEAL 643
              .|.|:                         |.:.|                       ::..|
Human   586 --APEAD-------------------------YLEAC-----------------------VVSVL 600

  Fly   644 LMHIKSKNIPGAILVFLPGWNLIFALMKFLQN--TNIFGDTSQYQILPCHSQIPRDEQRKVFEPV 706
            .:|:...  ||.|||||.|...|.|..:.||:  ..:.....:..:||.::.:|.|.|.::|:|.
Human   601 QIHVTQP--PGDILVFLTGQEEIEAACEMLQDRCRRLGSKIRELLVLPIYANLPSDMQARIFQPT 663

  Fly   707 PEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGR 771
            |.|..|::::|||||||:||:.|::|:|....:.|.:.....:.|......||.:..||.|||||
Human   664 PPGARKVVVATNIAETSLTIEGIIYVLDPGFCKQKSYNPRTGMESLTVTPCSKASANQRAGRAGR 728

  Fly   772 VRPGFCFTLCSRARFQ-ALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVDAVIE 835
            |..|.||.|.:...:| .||:...||:.||.|..:.|.:|.|.:..:.||  ..|:|||.:.::.
Human   729 VAAGKCFRLYTAWAYQHELEETTVPEIQRTSLGNVVLLLKSLGIHDLMHF--DFLDPPPYETLLL 791

  Fly   836 AEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEVFSL 900
            |...|..:..|:...|||..||.:|.||::|.|.||::....:.|::.:..:|:..|..:.:|..
Human   792 ALEQLYALGALNHLGELTTSGRKMAELPVDPMLSKMILASEKYSCSEEILTVAAMLSVNNSIFYR 856

  Fly   901 DIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQ 965
            ...:...|::.:........||:.::.....|..     ....:::|....:|..:|....|.::
Human   857 PKDKVVHADNARVNFFLPGGDHLVLLNVYTQWAE-----SGYSSQWCYENFVQFRSMRRARDVRE 916

  Fly   966 QLLDLLQQ 973
            ||..||::
Human   917 QLEGLLER 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634	12/41 (29%)
		DSRM	170..240	CDD:214634	10/71 (14%)
		DEXDc	393..569	CDD:214692	80/181 (44%)
		DEXDc	402..542	CDD:238005	63/145 (43%)
		ATP-synt_B	<584..644	CDD:304375	3/59 (5%)
		Helicase_C	643..772	CDD:278689	46/130 (35%)
		HA2	842..926	CDD:214852	20/83 (24%)
		OB_NTP_bind	974..1078	CDD:285018	256/983 (26%)
DHX16	NP_003578.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..207		32/159 (20%)
		PTZ00121	<148..376	CDD:173412	50/286 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..391		3/19 (16%)
		HrpA	390..1028	CDD:224557	190/608 (31%)
		DEAH box	520..523		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810