DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and AT1G58050

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_176102.1	Gene:	AT1G58050 / 842172	AraportID:	AT1G58050	Length:	1417	Species:	Arabidopsis thaliana

Alignment Length:	1332	Identity:	392/1332 - (29%)
Similarity:	600/1332 - (45%)	Gaps:	296/1332 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 EVRVEPNTYIGVGNSTNKKDAEK----NACR----DFVN-YLVRV--GKLNTNDVPADAGASGGG 89
            ||:..|.:.:.| ...:|:|.|:    ::|:    |::: |:.|:  .:|.::|   |......|
plant   157 EVKEVPESEVLV-RVKSKRDEEEEDSLSSCQPSQADWIHQYMKRLEEEELESSD---DERDKVSG 217

  Fly    90 PRT----GLEGAGMAGGSGQQKRVFDGQSGPQDLGEAYRPLNHDGGDGGNRYSVIDRIQEQRDMN 150
            ||:    ..|.......:.:.||..| :||....|.|...|..:....|...::::. :.|||..
plant   218 PRSFEVIAKEYCVERYNAIKAKRKGD-KSGQSQAGLAICKLKEEMNALGPSEAILES-EFQRDRQ 280

  Fly   151 EAEAF---DVNAAIHGNWTIENAKERLNIYKQTNNIRDDYKY--TPVG---PEHARSFLAELSI- 206
            :.|..   :|.:::     :::..|.:|.......:.||...  .|||   .|...|.::..|:
plant   281 DCEGAREKEVASSV-----LDDVHESVNADAFFFQLFDDLTLDTNPVGSCKSEEQESVVSNDSLD 340

  Fly   207 --------------YVPA------LNRTVTARE----------SGSNKKSASKSCALSLVRQL-- 239
                          |||:      |.:....||          :|..||..::....:|:.||
plant   341 DLDLGDLFDEDVPPYVPSPHELLELQKKEIMRELCNEKHLTKLNGIWKKGEAQKIPKALLHQLCQ 405

  Fly   240 --------------------FHLNVIEPFSGTLKKKKD---------------EQLKPYPVKLSP 269
                                :..:|:...||..|.::.               |.::....:::.
plant   406 RSGWIAPKFNKVTGEGRNFSYTTSVMRKSSGFGKSRQAGGLVTIQLPHQVEDFESIQDAQNRVAA 470

  Fly   270 NLINKIDEVIKGLDLPVVNPRNIKIELDGPPIPLIV------NLSRIDSSQQDGEKRQESSVIPW 328
            ..::|:..     ||||      ...:..|...|::      :|......:|..||..||.:
plant   471 FALHKLFS-----DLPV------HFAITEPYASLVLIWKQEESLGITSREEQRREKFVESLL--- 521

  Fly   329 APPQANWNTWHACNIDEGELATTS----------------IDDL-------------SMDYE-RS 363
                         ..|...|.|||                .|||             ||..| .|
plant   522 -------------EADNFSLTTTSRGIHSALPMVDSCVKENDDLDVVKSNHRARRNSSMAAECSS 573

  Fly   364 LRDRRQND---NEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDY 425
            |:.:::|.   .:|:..|:.|..|||:.::.:||..:.:..|:::.|.||.|||||:.|:||||.
plant   574 LKQKQENKKKMQKYKDMLKTRAALPISEVKKDILQKLKEKDVLVVCGETGSGKTTQVPQFILDDM 638

  Fly   426 ICSGQGGYANIYVTQPRRISAISVAERVARERCEQL----GDTVGYSVRFESVFPRPYGAILFCT 486
            |.||.|||.||..||||   ||:||:|||.||||..    ...|.|.||.::. ......:||||
plant   639 IDSGHGGYCNIICTQPR---AITVAQRVADERCEPPPGFDNSVVAYQVRHQNA-RSDKTRLLFCT 699

  Fly   487 VGVLLRKL--EAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVD------TYPDLHVILMSATID 543
            .|:|||||  :..|:.|:||||||:|||.:..||||:||:.:::      ..|.|.|||||||:|
plant   700 TGILLRKLVGDTTLKDVTHIIVDEVHERSLMGDFLLIILKSLIEKQSWDNALPKLKVILMSATVD 764

  Fly   544 TTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAES-------------------RRK 589
            ..:||:|||.||::...||..||..:|||||.:.|.::.:::|                   .|.
plant   765 AHQFSRYFGQCPIITAQGRTHPVTTYFLEDIYERTKYLLASDSPAALSSDTSITDKLGSVNVPRG 829

  Fly   590 RKEVE----DEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSK 650
            :|.:.    .:..|:||  |....:|:.:   ||          ::.:.|.::|||.|:.||...
plant   830 KKNLMLAGWGDSYLVSE--DSLNTSYDSI---KY----------IASAVVDYDLLEELICHIDDT 879

  Fly   651 NIPGAILVFLPGWNLIFALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIIL 715
            ...|||||||||.:.|..|:..|..:..|...|...:||.||.|...||:|||...|:|:.|:|:
plant   880 CEEGAILVFLPGMSEINMLLNRLAASYRFRGASGDWLLPLHSSIASTEQKKVFLRPPKGIRKVII 944

  Fly   716 STNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTL 780
            :||||||||||:|:|:|||..|.:...:..|..|:|....|.||.|..||.||||||:||.||:|
plant   945 ATNIAETSITIEDVVYVIDSGKHKENRYNPHKKLSSMVEDWVSKANARQRMGRAGRVKPGHCFSL 1009

  Fly   781 CSRARFQAL-EDNLTPEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVDAVIEAEVLLREMR 844
            .:|.||:.| .....|||.|.||.|:.|.||||.||.|..|||||||||...|:..|.:||.::.
plant  1010 YTRHRFEKLMRPYQVPEMLRVPLVELCLHIKLLGLGQIKPFLSKALEPPSESAINSAILLLHKVG 1074

  Fly   845 CLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEVF----------- 898
            .|:.::||||||..||:||::..:|||::.|.:|||...:..:|::.|.....|
plant  1075 ALEGDEELTPLGHHLAKLPVDLLIGKMLLYGGIFGCLSPILSIAAFLSCCKSPFVYAKDEQNVDR 1139

  Fly   899 -SLDIGQRRLANHQKALSGTKCSDHVAMIVASQMW-RREKQRGEHMEARFCDWKGLQMSTMNVIW 961
             .|.:...:|.:.....:..:.|||:.|:||.:.| |...::|......||:.|.|..|.|.::.
plant  1140 VKLALLSDKLESSSNLNNNDRQSDHLLMVVAYEKWVRILHEQGFKAAESFCESKFLNSSVMRMMR 1204

  Fly   962 DAKQQLLDLLQQAGFPEECMISHEVDERID-------------GDDPVLDVSLALLCLGLYPNIC 1013
            :.:.:...||...|............|..|             ..:|  :|..|:||.||.|||.
plant  1205 ERRVEFGMLLADIGLINLPKGKGRRKENFDVWFSDKTQPFNMYSQEP--EVVKAILCAGLCPNIA 1267

  Fly  1014 V-------------------HKEKRKVLTTESKAALLHKTSV--NCSNLAVTFPYPFFVFGEKIR 1057
            .                   |..||:|        .:|:.|:  ||.    .|.|||.||.||:.
plant  1268 EGLVNRLTKPAEETQRYAVWHDGKREV--------HIHRNSINKNCK----AFQYPFIVFLEKLE 1320

  Fly  1058 T-RAVSCKQLSMVSPLQVILFGSRKIDLAANNIVRVDNWLNFDIEPELAAKIGALKPALEDLITV 1121
            | :.|..:..::|||..::|||........:..|.:|.||......:.|.....|:..|..::
plant  1321 TKKVVYLQDTTVVSPFSILLFGGSINVHHQSGSVTIDGWLKLTAPAQTAVLFKELRLTLHSIL-- 1383

  Fly  1122 ACDNPSDILRLEEP----YAQLVKVVKDLCVK 1149
                 .|::|..|.    :.::||.:..|.::
plant  1384 -----KDLIRKPEKSGIVHNEVVKSMVHLLIE 1410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634	9/40 (23%)
		DSRM	170..240	CDD:214634	22/127 (17%)
		DEXDc	393..569	CDD:214692	91/187 (49%)
		DEXDc	402..542	CDD:238005	76/151 (50%)
		ATP-synt_B	<584..644	CDD:304375	14/82 (17%)
		Helicase_C	643..772	CDD:278689	60/128 (47%)
		HA2	842..926	CDD:214852	26/95 (27%)
		OB_NTP_bind	974..1078	CDD:285018	35/138 (25%)
AT1G58050	NP_176102.1	DSRM	396..476	CDD:294045	8/79 (10%)
		HrpA	558..1323	CDD:224557	292/797 (37%)
		DEXDc	615..762	CDD:238005	75/150 (50%)
		Helicase_C	871..1002	CDD:278689	61/130 (47%)
		HA2	1074..1168	CDD:214852	26/93 (28%)
		OB_NTP_bind	1209..1345	CDD:285018	39/149 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	116	1.000	Domainoid score	I1963
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278674at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820