Protein Alignment mle and FAS4

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: NP_174605.1
• Gene: FAS4 / 840232
• AraportID: AT1G33390
• Length: 1237
• Species: Arabidopsis thaliana
• Alignment Length: 1172
• Identity: 275/1172 - (23%)
• Similarity: 452/1172 - (38%)
• Gaps: 334/1172 - (28%)

  Fly   167 IENAKERLNIYKQTNNIRDDYKYTPVGPEHARSFLAELSIYVPALNRTVTARESGSNKKSASKSC 231
            :|..||:..::.:|..:.|.||.:    |...|.|....:    :.|:.|..|........||
plant    66 LEEDKEKEILFSKTAELLDKYKIS----EDVSSLLQSSKV----IGRSATKLEKRRRAMQLSK-- 120

  Fly   232 ALSLVRQLFHLNVIEPFSGTLKKKKDEQLKPYPVKLSPNLINKIDEVIKGLDLPVVNPRNIKIEL 296
                             :|...:..||.::.          |..|: ...:|.| ..|.:::||.
plant   121 -----------------AGVETEHSDESVEQ----------NDNDD-DSCMDEP-TTPEHVEIET 156

  Fly   297 DGPPI-----PLIVNLSRIDSSQQDGEKRQESSVIPWAPPQANWNTWHACNIDEGELATTSIDDL 356
              |..     ..:|:...:.|:::...|.:....:...|       ...|..|:.:    |:|.|
plant   157 --PTFVTDSEQQLVHADLMISAEESSSKLEVDDTVDMIP-------LTTCRDDDED----SMDGL 208

  Fly   357 SMDYERSLRDRR-----QNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQ 416
            ..:.:.:::..|     .:.:...:..|.|:.|||..|..||:.|||.:|.|||.|.||||||||
plant   209 IENEDVTVQGPRVPAFVVHVSRPAEVEETRKDLPIVMMEQEIMEAINRHPAVIISGQTGCGKTTQ 273

  Fly   417 IAQYILDDYICSGQGGYAN--IYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPY 479
            :.|::.:....|.|....:  |.:|||||::.::.|:|||.|...:||..||:.||::..... .
plant   274 VPQFLYEAGFGSKQFSSRSGIIGITQPRRVAVLATAKRVAFELGVRLGKEVGFQVRYDKKIGE-N 337

  Fly   480 GAILFCTVGVLLRKLEAG--LRGVSHIIVDEIHERDVNSDFLLVILRDMV----DTYPD------ 532
            .:|.|.|.|:|||:::..  ||..|.||:||.|||.:|:|.|:.:|..::    :.|.:
plant   338 SSIKFMTDGILLREIQNDFLLRRYSVIILDEAHERSLNTDILIGMLTRVIKIRQEYYEEQQKSLQ 402

  Fly   533 -------------LHVILMSATIDTTKF---SKYF-GICPVLEVPGRAFPVQQFFLEDIIQMTDF 580
                         |.:||||||:....|   .:.| .|.|::|||.|.:||...|.:. .::.|:
plant   403 SGGTVTSECQITPLKLILMSATLRVEDFVSGKRLFPNIPPLIEVPTRQYPVTIHFSKK-TEIVDY 466

  Fly   581 VPSA------------------------------ESRRK----------------RKEVED---- 595
            :..|                              |..||                :|:.:|
plant   467 IGEAYKKVMSIHKKLPQGGILVFVTGQREVDYLCEKLRKSSKELVVQAAKRDAYVKKKCDDGSFG 531

  Fly   596 ------------------EEQLLSEDKDEAEI---NYNKVC--EDKY-SQKTRN--------AMA 628
                              ..:..|..:|.::|   ||:...  ||.| |.:.|:        |.:
plant   532 GVDMKEIAEAFDDDSNNQNSRFSSHGEDPSDIGDGNYDDDFEEEDMYESDEDRDWETVDDGFASS 596

  Fly   629 MLSESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQNTNIFGDTSQYQILPCHSQ 693
            .:.|.  ..:.|.|....:..||  |::.. .|..::.....:..|..|.| ...:.::||.::.
plant   597 FVEEG--KLDALRAAFNALADKN--GSVSA-EPAKSIAAENQEAEQVKNKF-SPGKLRVLPLYAM 655

  Fly   694 IPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWAS 758
            :....|.:|||.|.:....::::||:||||:||..|.:|:|..:.::|.:.|...:.||...|.|
plant   656 LSPAAQLRVFEEVEKEERLVVVATNVAETSLTIPGIKYVVDTGRVKVKNYDSKTGMESYEVDWIS 720

  Fly   759 KTNLEQRKGRAGRVRPGFCFTLCSRARFQAL-EDNLTPEMFRTPLHEMALTIKLLRLGSIHHFLS 822
            :.:..||.|||||..||.|:.|.|.|.|..: |::..||:.:.|:..:.|.:|.:.:..:.:|..
plant   721 QASASQRAGRAGRTGPGHCYRLYSSAVFSNIFEESSLPEIMKVPVDGVILLMKSMNIPKVENFPF 785

  Fly   823 KALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMV-------------- 873
            ..  ||...|:.|||..|:.:..||:|..|||||:.::..|:.||..:|::
plant   786 PT--PPEPSAIREAERCLKALEALDSNGGLTPLGKAMSHYPMSPRHSRMLLTVIQMLKETRNYSR 848

  Fly   874 LGAVFGCADLMAIMASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQR 938
            ...:.|.|  :|.:|:.|.....:...: |:::  |..|....|         |..:..:|:|.|
plant   849 ANLILGYA--VAAVAALSLPNPLIMEFE-GEKK--NESKDADKT---------VKQEDKQRKKDR 899

  Fly   939 GEHMEAR-----------------------------FCDWKGLQMSTMNVIWDAKQQLLDLLQQA 974
            .|.::|.                             ||:..||.:.||:.:...|.|||.|:...
plant   900 KEKIKAARDRFSNPSSDALTVAYALHSFEVSENGMGFCEANGLHLKTMDEMSKLKDQLLRLVFNC 964

  Fly   975 GFPEECMISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKEKRKVLTTESKAALLHKTSVNCS 1039
            ..|.|...|.........|                    |.|..|...:|.||..||.....
plant   965 CKPSETEDSFSWTHGTIQD--------------------VEKSWRITTSTSSKTPLLQNEEE--- 1006

  Fly  1040 NLAVTFPYPFFVFGEKI----------RTRAVSCKQLSMVSPLQVILFGSRKIDLAANNIVRVDN 1094
                       :.||.|          :|||...:..::..|                  |.:..
plant  1007 -----------LLGEAICAGWADRVARKTRATEYQACAVQEP------------------VFLHR 1042

  Fly  1095 WLN-FDIEPELAAKIGALKPALEDLITVACDNPSDILRLEEPYAQ---------LVKVVKDLCVK 1149
            |.: .:..|||...                   |::|....||..         |||..|.|||.
plant  1043 WSSLINSAPELLVY-------------------SELLLTNRPYMHGATRVRPEWLVKHAKSLCVF 1088

  Fly  1150 SA 1151
            ||
plant  1089 SA 1090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684	15/73 (21%)
		DEXHc_DHX9	326..559	CDD:350730	84/268 (31%)
		HrpA	378..>889	CDD:441249	179/638 (28%)
		OB_NTP_bind	1002..1079	CDD:400182	15/86 (17%)
FAS4	NP_174605.1	HrpA	240..>834	CDD:441249	174/603 (29%)
		HA2	797..920	CDD:461295	30/136 (22%)
		OB_NTP_bind	1011..1085	CDD:400182	18/110 (16%)