DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mle and NIH

DIOPT Version :9

Sequence 1:NP_476641.1 Gene:mle / 35523 FlyBaseID:FBgn0002774 Length:1293 Species:Drosophila melanogaster
Sequence 2:NP_172152.1 Gene:NIH / 837177 AraportID:AT1G06670 Length:1576 Species:Arabidopsis thaliana


Alignment Length:1047 Identity:309/1047 - (29%)
Similarity:483/1047 - (46%) Gaps:214/1047 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   274 KIDEVIKGLDLPVVNPRNIKIELDGPPIPLIVNLSRIDSSQQDGEKRQESSVIPWA------PPQ 332
            |.|.:.|.....:...||.| |.:|..|....:..|.::..|.....:::.:.|..      ||:
plant    76 KGDGISKSDKRRMYEARNQK-EKEGDGISKSYSKHRYETRFQKAGGIRKTRISPKKLKCVSFPPE 139

  Fly   333 AN------WNTWHACNIDEGELATTSI-------------DDL-------SMDYER---SLRDRR 368
            |.      :..:..|   :|:...||:             ||.       ..|.|.   ||..|.
plant   140 AKAVLHDLFTRYPPC---DGDTTGTSLGIYTTGNVNSNWKDDFFKKPHMTKHDIENNVVSLSSRL 201

  Fly   369 QNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGY 433
            :.:..:|:..|.|.|||||:.|..|::|:..|.||:|.|.||||||||:.||:| |::...:...
plant   202 KKERHFREIFEARSKLPIASFRDAIISAVESNQVVLIAGETGCGKTTQVPQYLL-DHMWHSKKEA 265

  Fly   434 ANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRKL---- 494
            ..|..|||||||||||::|::.||.|.:|.||||.||.:|...|. .:::|||.|:|||.|    
plant   266 CKIICTQPRRISAISVSDRISWERGETIGRTVGYKVRLQSEGGRE-SSVVFCTNGILLRVLIGKG 329

  Fly   495 -EAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLE 558
             .:.:..::|||||||||||..|||:|:||||::.:.|.|.:||||||:|..:||:|||.|||:.
plant   330 VNSSVPDITHIIVDEIHERDSYSDFMLMILRDLLPSNPHLRLILMSATLDAERFSEYFGGCPVVR 394

  Fly   559 VPGRAFPVQQFFLEDIIQMTDFVPSAE--SRRKRKEVEDEEQ---------------------LL 600
            |||..:||:.|||:|.:.:.:...::.  |..|| :.:||::                     |:
plant   395 VPGFTYPVRTFFLDDALSVLNSDKNSHLLSAVKR-DFKDEDKVSLDEAIDLAWTNDEFDCLVDLV 458

  Fly   601 SEDKDEAEINY-------------------NKVCE------------------------------ 616
            |.:......||                   :.||:                              
plant   459 SSEGSHEAYNYQNSTTGLTPLMVFAGKGRVSDVCKLLSVGADCTLKSKEGITALELAEKENQFET 523

  Fly   617 ----------------------DKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVF 659
                                  |||       ||.:...:|...|:..|:..|.|.:..||||||
plant   524 AQIIREHAGNIQSNSQQAQDLLDKY-------MATIKPEEVDVGLIVKLMKKICSDSKDGAILVF 581

  Fly   660 LPGWNLIFALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSI 724
            ||||..|....:.|.:...|..::::.||..||::|.:||:|||...|.|..||:|:|||||:::
plant   582 LPGWEEISKTKEKLLDDRFFAHSAKFIILCLHSRVPAEEQKKVFNRPPRGCRKIVLATNIAESAV 646

  Fly   725 TIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQAL 789
            ||||:|:|||..:.:.|.:..:|::::..:.|.||.|.:||.|||||.:.|.|:.|.|:.|..:|
plant   647 TIDDVVYVIDSGRMKEKSYDPYNDVSTLQSSWVSKANAKQRAGRAGRCQAGICYHLYSKLRAASL 711

  Fly   790 EDNLTPEMFRTPLHEMALTIKLLRLG-SIHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELT 853
            .:...||:.|.|:.|:.|.:|:|... :::.||.|.::||...::..|.::|:::..|...:|||
plant   712 PEYRVPEVMRMPVDELCLQVKMLDPNCNVNDFLQKLMDPPVAQSIENALIILKDIGALTPEEELT 776

  Fly   854 PLGRLLARLPIEPRLGKMMVLGAVFGCAD---LMAIMASYSSTFSEVFSLDIGQRR---LANHQK 912
            .||:...:||:.||:.||:....:..|.|   ::|..|.....|:  ..|..|.|:   .|.|:.
plant   777 ELGQKFGQLPVHPRISKMIYFAILVNCLDPALILACAADEKDPFT--MPLSPGDRKKAAAAKHEL 839

  Fly   913 ALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFP 977
            |......|||:|.:.|.|.|:..|..|:..|  ||....:....|..:.|..::|...|.:.|  
plant   840 ASLYGDHSDHLATVAAFQCWKNAKASGQAKE--FCSKYFISQVVMKRLDDLCRKLQGELNRHG-- 900

  Fly   978 EECMISHEVDERIDGDDPVLDVSLALLCLGLYP---NIC-VHKEK-RKVLTTESKAAL-LHKTSV 1036
              .:.|...:..::..||  .:..|::.:||||   .:| :.|.: |.|:.|.:.|.: :...|.
plant   901 --VIPSSSSNCSLNAHDP--GILRAVIAVGLYPMLGRMCPLSKNRTRSVIETIAGAKVRVPSLSN 961

  Fly  1037 NCSNLAVTFPYPFFVFGEKIR-TRAVSCKQLSMVSPLQVILFG---------------------- 1078
            |....:..|.....||.|..| ...|..:..:::..:.|:||.                      
plant   962 NVDMSSTKFDEALIVFDEITRGDWGVVIRSCTVLPTIPVLLFSREIAVSTTESYDAVKSDDEEDH 1026

  Fly  1079 ------------------SRKIDLAANNIVR--VDNWLNFDIEPELAAKIGALKPALEDLITVAC 1123
                              ..||.|...|.|:  ||.||.|.:.....|::..|:..|...|....
plant  1027 KVGNVGDAMDIDKEVGRPGEKIMLGPENSVKVVVDRWLPFKVTAFEIAQMYILRERLMASILFKV 1091

  Fly  1124 DNPSDIL 1130
            .:|.:.|
plant  1092 KHPKENL 1098

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mleNP_476641.1 DSRM 4..68 CDD:214634
DSRM 170..240 CDD:214634
DEXDc 393..569 CDD:214692 93/180 (52%)
DEXDc 402..542 CDD:238005 75/144 (52%)
ATP-synt_B <584..644 CDD:304375 18/153 (12%)
Helicase_C 643..772 CDD:278689 56/128 (44%)
HA2 842..926 CDD:214852 27/89 (30%)
OB_NTP_bind 974..1078 CDD:285018 25/110 (23%)
NIHNP_172152.1 R3H_DEXH_helicase 18..76 CDD:100077 309/1047 (30%)
DEXDc 223..401 CDD:214692 92/179 (51%)
DEXDc 234..378 CDD:238005 75/145 (52%)
ANK <441..527 CDD:238125 6/85 (7%)
Ank_5 461..515 CDD:290568 4/53 (8%)
ANK repeat 475..505 CDD:293786 2/29 (7%)
ANK repeat 507..533 CDD:293786 0/25 (0%)
Helicase_C 563..693 CDD:278689 55/129 (43%)
HA2 766..851 CDD:214852 26/86 (30%)
OB_NTP_bind 890..1007 CDD:285018 28/122 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 174 1.000 Domainoid score I1108
eggNOG 1 0.900 - - E1_COG1643
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D278674at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.820

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