Protein Alignment mle and NIH

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: NP_172152.1
• Gene: NIH / 837177
• AraportID: AT1G06670
• Length: 1576
• Species: Arabidopsis thaliana
• Alignment Length: 1047
• Identity: 309/1047 - (29%)
• Similarity: 483/1047 - (46%)
• Gaps: 214/1047 - (20%)

  Fly   274 KIDEVIKGLDLPVVNPRNIKIELDGPPIPLIVNLSRIDSSQQDGEKRQESSVIPWA------PPQ 332
            |.|.:.|.....:...||.| |.:|..|....:..|.::..|.....:::.:.|..      ||:
plant    76 KGDGISKSDKRRMYEARNQK-EKEGDGISKSYSKHRYETRFQKAGGIRKTRISPKKLKCVSFPPE 139

  Fly   333 AN------WNTWHACNIDEGELATTSI-------------DDL-------SMDYER---SLRDRR 368
            |.      :..:..|   :|:...||:             ||.       ..|.|.   ||..|.
plant   140 AKAVLHDLFTRYPPC---DGDTTGTSLGIYTTGNVNSNWKDDFFKKPHMTKHDIENNVVSLSSRL 201

  Fly   369 QNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGY 433
            :.:..:|:..|.|.|||||:.|..|::|:..|.||:|.|.||||||||:.||:| |::...:...
plant   202 KKERHFREIFEARSKLPIASFRDAIISAVESNQVVLIAGETGCGKTTQVPQYLL-DHMWHSKKEA 265

  Fly   434 ANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRKL---- 494
            ..|..|||||||||||::|::.||.|.:|.||||.||.:|...|. .:::|||.|:|||.|
plant   266 CKIICTQPRRISAISVSDRISWERGETIGRTVGYKVRLQSEGGRE-SSVVFCTNGILLRVLIGKG 329

  Fly   495 -EAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLE 558
             .:.:..::|||||||||||..|||:|:||||::.:.|.|.:||||||:|..:||:|||.|||:.
plant   330 VNSSVPDITHIIVDEIHERDSYSDFMLMILRDLLPSNPHLRLILMSATLDAERFSEYFGGCPVVR 394

  Fly   559 VPGRAFPVQQFFLEDIIQMTDFVPSAE--SRRKRKEVEDEEQ---------------------LL 600
            |||..:||:.|||:|.:.:.:...::.  |..|| :.:||::                     |:
plant   395 VPGFTYPVRTFFLDDALSVLNSDKNSHLLSAVKR-DFKDEDKVSLDEAIDLAWTNDEFDCLVDLV 458

  Fly   601 SEDKDEAEINY-------------------NKVCE------------------------------ 616
            |.:......||                   :.||:
plant   459 SSEGSHEAYNYQNSTTGLTPLMVFAGKGRVSDVCKLLSVGADCTLKSKEGITALELAEKENQFET 523

  Fly   617 ----------------------DKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVF 659
                                  |||       ||.:...:|...|:..|:..|.|.:..||||||
plant   524 AQIIREHAGNIQSNSQQAQDLLDKY-------MATIKPEEVDVGLIVKLMKKICSDSKDGAILVF 581

  Fly   660 LPGWNLIFALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSI 724
            ||||..|....:.|.:...|..::::.||..||::|.:||:|||...|.|..||:|:|||||:::
plant   582 LPGWEEISKTKEKLLDDRFFAHSAKFIILCLHSRVPAEEQKKVFNRPPRGCRKIVLATNIAESAV 646

  Fly   725 TIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQAL 789
            ||||:|:|||..:.:.|.:..:|::::..:.|.||.|.:||.|||||.:.|.|:.|.|:.|..:|
plant   647 TIDDVVYVIDSGRMKEKSYDPYNDVSTLQSSWVSKANAKQRAGRAGRCQAGICYHLYSKLRAASL 711

  Fly   790 EDNLTPEMFRTPLHEMALTIKLLRLG-SIHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELT 853
            .:...||:.|.|:.|:.|.:|:|... :::.||.|.::||...::..|.::|:::..|...:|||
plant   712 PEYRVPEVMRMPVDELCLQVKMLDPNCNVNDFLQKLMDPPVAQSIENALIILKDIGALTPEEELT 776

  Fly   854 PLGRLLARLPIEPRLGKMMVLGAVFGCAD---LMAIMASYSSTFSEVFSLDIGQRR---LANHQK 912
            .||:...:||:.||:.||:....:..|.|   ::|..|.....|:  ..|..|.|:   .|.|:.
plant   777 ELGQKFGQLPVHPRISKMIYFAILVNCLDPALILACAADEKDPFT--MPLSPGDRKKAAAAKHEL 839

  Fly   913 ALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFP 977
            |......|||:|.:.|.|.|:..|..|:..|  ||....:....|..:.|..::|...|.:.|
plant   840 ASLYGDHSDHLATVAAFQCWKNAKASGQAKE--FCSKYFISQVVMKRLDDLCRKLQGELNRHG-- 900

  Fly   978 EECMISHEVDERIDGDDPVLDVSLALLCLGLYP---NIC-VHKEK-RKVLTTESKAAL-LHKTSV 1036
              .:.|...:..::..||  .:..|::.:||||   .:| :.|.: |.|:.|.:.|.: :...|.
plant   901 --VIPSSSSNCSLNAHDP--GILRAVIAVGLYPMLGRMCPLSKNRTRSVIETIAGAKVRVPSLSN 961

  Fly  1037 NCSNLAVTFPYPFFVFGEKIR-TRAVSCKQLSMVSPLQVILFG---------------------- 1078
            |....:..|.....||.|..| ...|..:..:::..:.|:||.
plant   962 NVDMSSTKFDEALIVFDEITRGDWGVVIRSCTVLPTIPVLLFSREIAVSTTESYDAVKSDDEEDH 1026

  Fly  1079 ------------------SRKIDLAANNIVR--VDNWLNFDIEPELAAKIGALKPALEDLITVAC 1123
                              ..||.|...|.|:  ||.||.|.:.....|::..|:..|...|....
plant  1027 KVGNVGDAMDIDKEVGRPGEKIMLGPENSVKVVVDRWLPFKVTAFEIAQMYILRERLMASILFKV 1091

  Fly  1124 DNPSDIL 1130
            .:|.:.|
plant  1092 KHPKENL 1098

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684
		DEXHc_DHX9	326..559	CDD:350730	112/272 (41%)
		HrpA	378..>889	CDD:441249	216/613 (35%)
		OB_NTP_bind	1002..1079	CDD:400182	22/123 (18%)
NIH	NP_172152.1	R3H_DEXH_helicase	18..76	CDD:100077	309/1047 (30%)
		HrpA	217..>820	CDD:441249	214/612 (35%)
		ANKYR	<468..575	CDD:440430	14/113 (12%)
		ANK repeat	475..505	CDD:293786	2/29 (7%)
		ANK repeat	507..533	CDD:293786	0/25 (0%)
		OB_NTP_bind	919..1007	CDD:400182	22/87 (25%)