Protein Alignment mle and EMB3011

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: NP_196805.2
• Gene: EMB3011 / 831141
• AraportID: AT5G13010
• Length: 1255
• Species: Arabidopsis thaliana
• Alignment Length: 1271
• Identity: 307/1271 - (24%)
• Similarity: 492/1271 - (38%)
• Gaps: 370/1271 - (29%)

  Fly    21 DIRQTGPKNRQRFLCEVRVEPNTYIGVGNSTNKKDAEKNACRDFVNYLVRVGKLNTNDVPADAGA 85
            |.|....|:..:...|.:|...:.|.|.:|.:::|....:..||       |..||..|.:....
plant    42 DARAIEKKDNAKTEGEFKVPKKSAISVTSSLDEEDKSDVSGLDF-------GTENTRPVHSSRRY 99

  Fly    86 SGGGPRTGLEGAGMAGGSGQQKRVFDGQSGPQDLGEAYRPL----NHDGGDGGNRYSVIDRIQEQ 146
            .....|:         .|.|:..|....:|..|:....|.|    :::.| |.||:    |.:.:
plant   100 REKSSRS---------QSAQESTVTTENAGTSDISITPRTLSCTSSYERG-GSNRH----REEHR 150

  Fly   147 RDMNEA------------------EAF-DVNAAIHGNWTIENAKERLNIYKQT------NNIRDD 186
            ||.:|.                  |:: ..:...||     ..:.|.|...:|      ::.:|:
plant   151 RDRSETPRSRQRNTYDEMDHYRRRESYRQSDRDYHG-----EKRRRYNSDWRTPGRSDWDDGQDE 210

  Fly   187 YKYTPVG---------PEHA----------------------RSFLAELSIYVPALNRTVTARES 220
            ::.:|.|         |:.:                      ||.::..|.:.......:..|.|
plant   211 WERSPHGDRGSSYSRRPQPSPSPMLAAASPDARLASPWLDTPRSTMSSASPWDMGAPSPIPIRAS 275

  Fly   221 GSNKKSAS-----KSCALSLVRQ------------------------------------------ 238
            ||:.:|:|     :|..|:..|:
plant   276 GSSIRSSSSRYGGRSNQLAYSREGDLTNEGHSDEDRSQGAEEFKHEITETMRVEMEYQSDRAWYD 340

  Fly   239 ------LFHLNVIEPFSG---TLKKKKDE----------------QLKPYPVKLSPNLINKIDEV 278
                  ||..:....|.|   :|:||:.|                |.|.|....:.|...:..::
plant   341 TDEGNSLFDADSASFFLGDDASLQKKETELAKRLVRRDGSKMSLAQSKKYSQLNADNAQWEDRQL 405

  Fly   279 IKGLDLPVVNPRNIKIELDG--------------PPIPLIVNLSRIDSSQQDGE---KRQESSVI 326
            ::.   ..|....::.|.|.              ||.             .||.   .:|...|:
plant   406 LRS---GAVRGTEVQTEFDSEEERKAILLVHDTKPPF-------------LDGRVVYTKQAEPVM 454

  Fly   327 PWAPP-------------------------QANWNTWHACNIDEGEL-----------ATTSI-- 353
            |...|                         ::....|.....:.|.:           |.|::
plant   455 PVKDPTSDMAIISRKGSGLVKEIREKQSANKSRQRFWELAGSNLGNILGIEKSAEQIDADTAVVG 519

  Fly   354 DDLSMDY--ERSLRDRRQNDNEYRQF------LEFREKLPIAAMRSEILTAINDNPVVIIRGNTG 410
            ||..:|:  |.......:......:|      .|.|:.|||.::|.|:|..|.:|.|:::.|.||
plant   520 DDGEVDFKGEAKFAQHMKKGEAVSEFAMSKTMAEQRQYLPIFSVRDELLQVIRENQVIVVVGETG 584

  Fly   411 CGKTTQIAQYILDD-YICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESV 474
            .|||||:.||:.:| |..:|..|     .|||||::|:|||:||:.|...:|||.:||::|||.|
plant   585 SGKTTQLTQYLHEDGYTINGIVG-----CTQPRRVAAMSVAKRVSEEMETELGDKIGYAIRFEDV 644

  Fly   475 FPRPYGAILFCTVGVLLRKL--EAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVIL 537
             ..|...|.:.|.|||||:.  ::.|.....:::||.|||.:|:|.|..||:.:|....|..:|:
plant   645 -TGPNTVIKYMTDGVLLRETLKDSDLDKYRVVVMDEAHERSLNTDVLFGILKKVVARRRDFKLIV 708

  Fly   538 MSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSE 602
            .|||::..|||.:||..|:..:|||.|||
plant   709 TSATLNAQKFSNFFGSVPIFNIPGRTFPV------------------------------------ 737

  Fly   603 DKDEAEINYNKV-CEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLI 666
                 .|.|:|. |||......:.||.                :||.|.  ||.||:|:.|.:.|
plant   738 -----NILYSKTPCEDYVEAAVKQAMT----------------IHITSP--PGDILIFMTGQDEI 779

  Fly   667 ----FALMKFLQN---------TNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTN 718
                |:|.:.::.         ||:.       |||.:||:|.|.|.|:|:...:|..|.|::||
plant   780 EAACFSLKERMEQLVSSSSREITNLL-------ILPIYSQLPADLQAKIFQKPEDGARKCIVATN 837

  Fly   719 IAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSR 783
            |||||:|:|.|.:|||....:||:|.....:.:......|:...:||.|||||..||.|:.|.:.
plant   838 IAETSLTVDGIYYVIDTGYGKMKVFNPRMGMDALQVFPISRAASDQRAGRAGRTGPGTCYRLYTE 902

  Fly   784 ARFQALEDNL---TPEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVDAVIEAEVLLREMRC 845
            :.:  |.:.|   .||:.||.|..:.|.:|.|::.::..|  ..::|||.:.::.:...|..:..
plant   903 SAY--LNEMLPSPVPEIQRTNLGNVVLLLKSLKIDNLLDF--DFMDPPPQENILNSMYQLWVLGA 963

  Fly   846 LDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEVF-SLDIGQRRLAN 909
            |:....||.||..:...|::|.|.||:::|....|.|.:..:.|..|..|..| ..:..:...|.
plant   964 LNNVGGLTDLGWKMVEFPLDPPLAKMLLMGERLDCIDEVLTIVSMLSVPSVFFRPKERAEESDAA 1028

  Fly   910 HQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQ- 973
            .:|..  ...|||:.::...|.|:....||:.....:...|||:.:.     :.:.||||:|:|
plant  1029 REKFF--VPESDHLTLLNVYQQWKEHDYRGDWCNDHYLQVKGLRKAR-----EVRSQLLDILKQL 1086

  Fly   974 --------------------AGFPEECMISHEVDERID---GDDPVLDVSLALLCLGLYPNICVH 1015
                                |.|.....:. .|.|.::   |....|..|.||..||..|:..|:
plant  1087 KIELRSCGPDWDIVRKAICSAYFHNSARLK-GVGEYVNCRTGMPCHLHPSSALYGLGYTPDYVVY 1150

  Fly  1016 KEKRKVLTTESKAALLHKTSVNCSNLAVTFPYPFFV 1051
            .|  .:|||  |..:...|||....||...|..|.|
plant  1151 HE--LILTT--KEYMQCATSVEPHWLAELGPMFFSV 1182

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683	11/48 (23%)
		DSRM_DHX9_rpt2	167..241	CDD:380684	20/163 (12%)
		DEXHc_DHX9	326..559	CDD:350730	88/281 (31%)
		HrpA	378..>889	CDD:441249	174/530 (33%)
		OB_NTP_bind	1002..1079	CDD:400182	19/50 (38%)
EMB3011	NP_196805.2	U2AF_lg	155..>226	CDD:273727	10/75 (13%)
		HrpA	558..>1177	CDD:441249	217/706 (31%)