DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mle and AT2G35920

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_001323636.1	Gene:	AT2G35920 / 818165	AraportID:	AT2G35920	Length:	1027	Species:	Arabidopsis thaliana

Alignment Length:	1107	Identity:	354/1107 - (31%)
Similarity:	549/1107 - (49%)	Gaps:	185/1107 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 NTNDVPADAGASGGGPRTGLEGAGMAGGSGQQKRVFDGQSGPQDLGEAYRPLNHDGGDGGNRYSV 139
            :|..:|.....|.||.|.|...:|..||.|...|                     ||.||.|...
plant    29 HTAAMPPHGPNSQGGRRGGGHSSGRRGGRGGGGR---------------------GGGGGGRGEQ 72

  Fly   140 --------IDRIQEQRDMNEAEAFDVNAAIH--GNWTIENAKERLNIYKQTNNIRDDYKYTPVGP 194
                    .:|:::|:  .|.|..|.|...:  ..|.....:|.|        |:.::..   |.
plant    73 RWWDPVWRAERLRQQQ--AEMEVLDENEWWNKIEQWKTGGEQEML--------IKRNFSR---GD 124

  Fly   195 EHARSFLA-ELSIYVPALNRTVTARESGSNKKSASKSCALSLVRQLFHLNVIEPFSGTLKKKKDE 258
            :...|.:| ::.:|..|.|:              .|:..:|.|....:...::...|:.:|:
plant   125 QQTLSDMALQMGLYFHAYNK--------------GKALVVSKVPLPDYRADLDERHGSTQKE--- 172

  Fly   259 QLKPYPVKLSPNLINKIDEVIK--------GLDLPVVNPRNIKIELDGPPIPLIVNLSRIDSSQQ 315
                  :|:|.....|:..::|        |......|                        .||
plant   173 ------IKMSTETERKLGSLLKTTQESGSSGASASAFN------------------------DQQ 207

  Fly   316 D-----GEKRQES-SVIPWAPPQANWNTWHACNIDEGELATTSIDDLSMD-YERSLRDRRQN--- 370
            |     |.||.:| |.:|                          |.|..: :..:|::|::.
plant   208 DRTSTLGLKRPDSASKLP--------------------------DSLEKEKFSFALKERQEKLKA 246

  Fly   371 DNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYAN 435
            ....:....||||||...|:.|.|.:::.|.|:::.|.||||||||:.|:||::.|.|.:|...|
plant   247 TESVKALKAFREKLPAFKMKEEFLNSVSQNQVLVVSGETGCGKTTQLPQFILEEEISSLRGADCN 311

  Fly   436 IYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRKL--EAGL 498
            |..||||||||||||.|::.||.|.:|::|||.:|.||. ......:||||.|||||:|  :..|
plant   312 IICTQPRRISAISVASRISAERGESIGESVGYQIRLESK-RSDQTRLLFCTTGVLLRRLIEDPNL 375

  Fly   499 RGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRA 563
            ..|||::|||||||.:|.||||:||||::...|||.:|||||||:...||.|||..|.:.:||..
plant   376 TNVSHLLVDEIHERGMNEDFLLIILRDLLPRRPDLRLILMSATINADMFSTYFGNSPTMHIPGFT 440

  Fly   564 FPVQQFFLEDIIQMTDF-VPSAE-------SRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYS 620
            |||.:.||||:::.:.: :.|::       ||.:|:|.|.::..|:...::.:||.:   ...||
plant   441 FPVAELFLEDVLEKSRYNIKSSDSGNYQGSSRGRRRESESKKDDLTTLFEDIDINSH---YKSYS 502

  Fly   621 QKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQNTNIFGDTSQY 685
            ..|||::...|.:.:..:|:||.:.||......|||||||.||:.|..|::.:...|..||:|::
plant   503 SATRNSLEAWSGAQIDVDLVEATIEHICRLEGGGAILVFLTGWDEISKLLEKINMNNFLGDSSKF 567

  Fly   686 QILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLT 750
            .:||.|..:|...||::|:..|....||:|:|||||:||||||:|:|:|..||:...:.:.|.:.
plant   568 LVLPLHGSMPTVNQREIFDRPPPNKRKIVLATNIAESSITIDDVVYVVDCGKAKETSYDALNKVA 632

  Fly   751 SYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLLRLG 815
            .....|.||.:..||:||||||:.|.|:.|..:..:.|......||:.||||.|:.|.||.|::|
plant   633 CLLPSWISKASAHQRRGRAGRVQAGVCYRLYPKVIYDAFPQYQLPEIIRTPLQELCLHIKSLQVG 697

  Fly   816 SIHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGC 880
            ||..||:|||:||...||..|..||:.:..|:..:|||||||.|..||::|.:|||:::||:|.|
plant   698 SIGSFLAKALQPPDALAVENAIELLKTIGALNDVEELTPLGRHLCTLPVDPNIGKMLLIGAIFQC 762

  Fly   881 ADLMAIMASYSSTFSEVFSLDIGQRRLANHQKA-LSGTKCSDHVAMIVASQMWRREKQRGEHMEA 944
            .: .|:..:.:..:...|.|.:.::..|:..|. .:|..||||:|::.|.:.:|..|:.|.  |.
plant   763 VN-PALTIAAALAYRSPFVLPLNRKEEADEAKRYFAGDSCSDHIALLKAYEGYRDAKRGGN--EK 824

  Fly   945 RFCDWKG-LQMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDP--------VLDVS 1000
            .|| |:. |...|:.::.|.:.|.||||...||             :|...|        .:::.
plant   825 DFC-WQNFLSPVTLRMMEDMRNQFLDLLSDIGF-------------VDKSKPNAYNQYSYDMEMI 875

  Fly  1001 LALLCLGLYPNI--CVHKEKRKVLTTESKAAL-LHKTSVNCS-NLAVTFPYPFFVFGEKIRTRAV 1061
            .|:||.|||||:  |..:.||....|:....: :|..|||.. ||   |..|:.|:.||::|.:|
plant   876 SAVLCAGLYPNVVQCKRRGKRTAFYTKELGKVDIHPGSVNARVNL---FSLPYLVYSEKVKTTSV 937

  Fly  1062 SCKQLSMVSPLQVILFGSRKI-DLAANNIVRVDNWLNFDIEPELAAKIGALKPALEDLITVACDN 1125
            ..:..:.:|...:::||...| ......|..:..:|:|.....:...|..|:..::.|:....::
plant   938 YIRDSTNISDYALLMFGGNLIPSKTGEGIEMLGGYLHFSASKNILELIQRLRGEVDKLLNKKIED 1002

  Fly  1126 PS 1127
            ||
plant  1003 PS 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634	12/70 (17%)
		DEXDc	393..569	CDD:214692	94/177 (53%)
		DEXDc	402..542	CDD:238005	79/141 (56%)
		ATP-synt_B	<584..644	CDD:304375	17/66 (26%)
		Helicase_C	643..772	CDD:278689	54/128 (42%)
		HA2	842..926	CDD:214852	30/84 (36%)
		OB_NTP_bind	974..1078	CDD:285018	30/115 (26%)
AT2G35920	NP_001323636.1	HrpA	225..941	CDD:224557	290/765 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	174	1.000	Domainoid score	I1108
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278674at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3204
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820