Protein Alignment mle and MEE29

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: NP_181077.3
• Gene: MEE29 / 818101
• AraportID: AT2G35340
• Length: 1044
• Species: Arabidopsis thaliana
• Alignment Length: 1024
• Identity: 275/1024 - (26%)
• Similarity: 430/1024 - (41%)
• Gaps: 227/1024 - (22%)

  Fly   117 QDLGEAYRPLNHDGGDGGNRYSVIDRIQEQRDMNEAEAFDVNAAIHGNWTIENAKER-------- 173
            :|.....|.::.|..||..  |..:|:::||:..|.|              ::.:||
plant   146 EDKRNVRRKVSEDEDDGTE--SEEERLRDQREREELE--------------QHLRERDTARTRKL 194

  Fly   174 ----LNIYKQTNNIRDDYKYTPVGPEHARSFLAELSIYVPALNRTVTARESGSNKKSASKSCALS 234
                ::..:|...:|.|........|..|.|                :.:....|:...|  .|.
plant   195 TEPKMSKKEQEEFVRRDSAVDKGDIESLRKF----------------SWQEYMKKRKQKK--VLE 241

  Fly   235 LVRQLFHLNVIEPFSGTLKKKKDEQLKPYPVKLSPNLINKIDEVIKGLDLPVVNPRNIKIELDGP 299
            |...:..    ||:....:|..:.:::.:..|      .:|.|:||.......|....::.
plant   242 LKDDIED----EPYLFGDEKLTEREIREFRYK------REIYELIKKSTQEEDNVGEYRMP---- 292

  Fly   300 PIPLIVNLSRIDSSQQDG----EKRQESSVIPWAP--------PQANWNTWHACNIDEGELA--- 349
                       |:..|.|    |||...||..:..        |.|....|....|:...|.
plant   293 -----------DAYDQQGSVDQEKRFAVSVQRYRDMGSAEKMNPFAEQEAWEDHQIENAALKFGA 346

  Fly   350 -------------TTSIDDLSM------DYERSLRDRRQND----NEYRQFLEFREKLPIAAMRS 391
                         ...||.:..      :||..:..:...|    :.:....|.|:.|||...|.
plant   347 KNKEVSDNYEFVFEDQIDFIKASVLAGDNYEDEMHAKPSQDSAGKSAFHMLQEDRKALPIYTYRD 411

  Fly   392 EILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGY---ANIYVTQPRRISAISVAERV 453
            ::|.|:.|:.|:||.|.||.||||||.||:       .:.||   ..:..|||||::|:|||.||
plant   412 QLLNAVKDHQVLIIVGETGSGKTTQIPQYL-------HEAGYTKLGKVGCTQPRRVAAMSVAARV 469

  Fly   454 ARERCEQLGDTVGYSVRFESVFPRPYGAIL-FCTVGVLLRKL--EAGLRGVSHIIVDEIHERDVN 515
            |:|...:||..||||:|||......  .|| :.|.|:|||:|  |..|...|.|||||.|||.:.
plant   470 AQEMGGKLGHEVGYSIRFEDCTSEK--TILKYMTDGMLLRELLGEPDLGSYSVIIVDEAHERTLR 532

  Fly   516 SDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDF 580
            :|.|..:::|:....|||.:::.|||:|..|||.:|...|:...|||.:||      ||...|
plant   533 TDILFGLVKDIARARPDLKLLISSATMDAEKFSDFFDQAPIFRFPGRRYPV------DICFTT-- 589

  Fly   581 VPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLM 645
            .|.|                  |..:|.|.                              ..|.:
plant   590 APEA------------------DYMDAAIT------------------------------TVLTI 606

  Fly   646 HIKSKNIP-GAILVFLPGWNLIFALMKFLQN------TNIFGDTSQYQILPCHSQIPRDEQRKVF 703
            |:|.   | |.:||||||...|.|:.:.|::      |.|    .:..|.|.::.:|.:.|.|:|
plant   607 HVKE---PLGDVLVFLPGQEEIEAVEENLKHKIRGLGTKI----RELIICPIYANLPSELQAKIF 664

  Fly   704 EPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGR 768
            ||.|||..|::|:|||||||:|||.|.:|:|...::||.:.....:.|......||.:..||.||
plant   665 EPTPEGARKVVLATNIAETSLTIDGIKYVVDPGFSKMKSYNPRTGMESLLVTPISKASATQRTGR 729

  Fly   769 AGRVRPGFCFTLCSRAR-FQALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHFLS-KALEPPPVD 831
            |||..||.|:.|.:... :..||||..||:.||.|..:.|::|.|   .||:.|: ..::|||.:
plant   730 AGRTSPGKCYRLYTAFNYYNDLEDNTVPEIQRTNLASVVLSLKSL---GIHNLLNFDFMDPPPSE 791

  Fly   832 AVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCAD-LMAIMASYSSTFS 895
            |:|::..||..:..|:...|||..||.:|..|::|.|.||:|:...:.|:| :::|.|..|...|
plant   792 ALIKSLELLFALGALNQLGELTKAGRRMAEFPLDPMLSKMIVVSDKYKCSDEIISIAAMLSIGPS 856

  Fly   896 EVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVI 960
            ..:.....|....|..|........||:|.:.....|:.     .:...::|....:|:.:|...
plant   857 IFYRPKDKQVHADNAMKNFHVGNVGDHIAFLKIYNSWKE-----TNYSTQWCYENYIQVRSMKRA 916

  Fly   961 WDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKEKRKVLTTE 1025
            .|.:.||..||::.          |:|...:.::  ||.....:..|.:|:..      |:....
plant   917 RDIRDQLEGLLERV----------EIDVSSNANE--LDSIRKSIVAGFFPHTA------KLQKNG 963

  Fly  1026 SKAALLHKTSVN---CSNLAVTFPYPFFVFGEKIRTRAVSCKQLSMVSP 1071
            |...:.|..:|:   .|.|:...| .:.|:.:.:.|.....:|::.:.|
plant   964 SYRTVKHPQTVHIHPASGLSQVLP-RWVVYHQLVLTSKEYMRQVTELKP 1011

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684	12/85 (14%)
		DEXHc_DHX9	326..559	CDD:350730	91/272 (33%)
		HrpA	378..>889	CDD:441249	190/526 (36%)
		OB_NTP_bind	1002..1079	CDD:400182	13/73 (18%)
MEE29	NP_181077.3	DUF5401	<77..>282	CDD:375164	31/179 (17%)
		HrpA	403..>1031	CDD:441249	223/708 (31%)