DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and HVT1

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_850154.2	Gene:	HVT1 / 817631	AraportID:	AT2G30800	Length:	1299	Species:	Arabidopsis thaliana

Alignment Length:	1096	Identity:	313/1096 - (28%)
Similarity:	486/1096 - (44%)	Gaps:	238/1096 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 LSRIDSSQQDGEKRQ-------ESSVIPWAPPQAN------WNTWHACNIDEGELATTSIDDLS- 357
            ||...|..::|.|.:       |.......||.|:      :..:..|   :|:.|.||....|
plant    76 LSIFKSRHKNGNKNEANEKSNKEKLKCVSFPPGADVILQELFTHYPPC---DGDTAATSFTKYSG 137

  Fly   358 -----------------------MDYERSLRDRRQNDNEYRQFLEFREKLPIAAMRSEILTAIND 399
                                   ::...||..|.:.|...::..:.|.||||.:.:..|.:|:..
plant   138 NKGKQGQWKDDFFRKPQISSEEILEKVASLSSRLKKDKALKEITKLRSKLPITSFKDAITSAVES 202

  Fly   400 NPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDT 464
            |.|::|.|.||||||||:.||:| |::.|.:.....|..||||||||:||:||::.||.|.:|:.
plant   203 NQVILISGETGCGKTTQVPQYLL-DHMWSSKRETCKIVCTQPRRISAMSVSERISCERGESIGEN 266

  Fly   465 VGYSVRFESVFPRPYGAILFCTVGVLLRKL-----EAGLRGVSHIIVDEIHERDVNSDFLLVILR 524
            :||.||.:|...| :.:::|||.|:|||.|     .:.:..::|||||||||||..|||:|.|:|
plant   267 IGYKVRLQSKGGR-HSSVVFCTNGILLRVLVGKGSVSSVSDITHIIVDEIHERDCYSDFMLAIIR 330

  Fly   525 DMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQ------------- 576
            |::.:.|.|.:||||||:|..:||.|||.|||:.|||..:||:..:|||::.
plant   331 DLLPSNPHLRLILMSATLDAERFSGYFGGCPVVRVPGFTYPVRTLYLEDVLSILKSGGDNHLSST 395

  Fly   577 ----------------------------------MTDFVPSAESRR------------------- 588
                                              :.|.|.|..|..
plant   396 NLSISDHKLDLTDEDKLALDEAIILAWTNDEFDALLDLVSSRGSHEIYNYQHQSTWLTPLMVFAG 460

  Fly   589 -------------------KRK---------EVEDE---EQLLSEDKDEAEINYNKVCE--DKYS 620
                               |.|         |.|::   .|::.|..|.::.|..:..:  |||
plant   461 KGRISDVCMLLSFGADWSLKSKDGMTALELAEAENQLEAAQIIREHADNSQSNSQQGQQLLDKY- 524

  Fly   621 QKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQNTNIFGDTSQY 685
                  ||.::...|...|::.|:..|...:..||||||||||:.|....:.|.....|.|::::
plant   525 ------MATINPEQVDVSLIQQLMRKICGDSEDGAILVFLPGWDDINKTRQRLLENPFFADSAKF 583

  Fly   686 QILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLT 750
            .|:..||.:|..||:|||...|.|..||:|:|||||:::||||:|:|||..:.:.|.:..:||::
plant   584 DIICLHSMVPAGEQKKVFNRPPPGCRKIVLATNIAESAVTIDDVVYVIDSGRMKEKSYDPYNNVS 648

  Fly   751 SYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLLRLG 815
            :..:.|.||.|.:||:|||||.:||.|:.|.||.|..::.|...||:.|.|:.|:.|.:|:|...
plant   649 TLQSSWVSKANAKQRQGRAGRCQPGICYHLYSRLRAASMPDFKVPEIKRMPVEELCLQVKILDPN 713

  Fly   816 -SIHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFG 879
             ..:.||.|.|:||...::..|..:|:::..|...:|||.||.....||:.|.:.||:....:..
plant   714 CKTNDFLQKLLDPPVDQSIANALSILQDIGALTPQEELTELGEKFGHLPVHPLISKMLFFAVLVN 778

  Fly   880 CADLMAIMASYSSTFSEVFSLDIG--QRRLANHQKALSGTKC---SDHVAMIVASQMWRREKQRG 939
            |.| .|:..:.::.:.|.|::.:.  :|:.|...|....:.|   |||:|::.|.:.|:..|.||
plant   779 CLD-PALTLACAADYKEPFTMPMSPVERQKAAAAKLELASLCGGDSDHLAVVAAFECWKNAKGRG 842

  Fly   940 EHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLALL 1004
              :.|.||....:..|.|.::...:.||...|::.|.....:.|...:.|    ||  .:..|:|
plant   843 --LSAEFCSQYFVSPSAMKMLDQMRSQLESELKRHGIIPNDISSCSQNSR----DP--GILRAVL 899

  Fly  1005 CLGLYP---NIC--VHKEKRKVLTTESKAAL-LHKTSVNCSNLAVTFPYPFFVFGEKIR------ 1057
            .:||||   .:|  ....:|.::.|.|.|.: :|..|.|.:..:..:.....||.|..|
plant   900 AVGLYPMVGRLCPAFGNNRRTIVETASGAKVRVHSLSNNFNLSSKKYDESLLVFDEITRGDGGMH 964

  Fly  1058 ----TRAVSCKQLSMVSPLQVILFGSRKID-------------------LAAN------------ 1087
                |.|.....|.:.:.:.|...||...|                   :|||
plant   965 IRNCTVARDLPLLLISTEIAVAPTGSSDSDDSNEEEEDDEEVAANTNEEVAANTNEEGMDIHKEE 1029

  Fly  1088 ------------NIVR--VDNWLNFDIEPELAAKIGALKPALEDLITVACDNPSDILRLEEPY-- 1136
                        |.|:  ||.||.|.......|::..|:..|...|.....:|.:.|   .|:
plant  1030 SRRGAKMMSSPENSVKLVVDRWLPFRTTALEVAQMYILRERLMASILFKVTHPREHL---PPHLG 1091

  Fly  1137 AQLVKVVKDLCVKSAGDFGLQRESGILPHQSRQFSDGGGPPKRGRFETGRFTNSSF 1192
            |.:..:...|............||.:..|...:..|.||..::    ...|.||.|
plant  1092 ASMHAIAGILSYDGHAGLSCPPESMVPKHSRTEMYDTGGWEEK----PNSFLNSLF 1143

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634
		DEXDc	393..569	CDD:214692	90/180 (50%)
		DEXDc	402..542	CDD:238005	72/144 (50%)
		ATP-synt_B	<584..644	CDD:304375	16/111 (14%)
		Helicase_C	643..772	CDD:278689	56/128 (44%)
		HA2	842..926	CDD:214852	24/88 (27%)
		OB_NTP_bind	974..1078	CDD:285018	27/119 (23%)
HVT1	NP_850154.2	R3H_DEXH_helicase	22..80	CDD:100077	2/3 (67%)
		HrpA	153..>946	CDD:224557	258/810 (32%)
		ANK repeat	417..444	CDD:293786	4/26 (15%)
		ANK repeat	446..481	CDD:293786	0/34 (0%)
		PTZ00322	453..>506	CDD:140343	5/52 (10%)
		ANK repeat	483..507	CDD:293786	4/23 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	174	1.000	Domainoid score	I1108
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278674at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820