DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and DHX40

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_078888.4	Gene:	DHX40 / 79665	HGNCID:	18018	Length:	779	Species:	Homo sapiens

Alignment Length:	817	Identity:	220/817 - (26%)
Similarity:	356/817 - (43%)	Gaps:	150/817 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   367 RRQNDNEYRQFLEFREKL------------------------PIAAMRSEILTAINDNPVVIIRG 407
            |||.:.|..:.|: .|:|                        ||...|.:|:.|:.||..:|:.|
Human    13 RRQEEGERSRDLQ-EERLSAVCIADREEKGCTSQEGGTTPTFPIQKQRKKIIQAVRDNSFLIVTG 76

  Fly   408 NTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFE 472
            |||.|||||:.:|:.:    :|...:..|.|||||:::|||||:|||.|....||..|||.|||:
Human    77 NTGSGKTTQLPKYLYE----AGFSQHGMIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFD 137

  Fly   473 SVFPRPYGAILFCTVGVLLRKL--EAGLRGVSHIIVDEIHERDVNSDFLLVILRDMV-DTYPD-- 532
            ....:. .||.:.|.|.||:.:  :..|...|.||:||.|||.:.:|.|..:|:.:. :..|:
Human   138 DCSSKE-TAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQEKSPNRK 201

  Fly   533 --LHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVED 595
              |.|::||||::..|.|.:||.||:.::|||.:||::.|. ::|...|
Human   202 EHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFC-NLIGPRD---------------- 249

  Fly   596 EEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFL 660
                                               .|:....:.:..:.|.|....:.|.|||||
Human   250 -----------------------------------RENTAYIQAIVKVTMDIHLNEMAGDILVFL 279

  Fly   661 PG-------WNLIFALMKF------LQNTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTK 712
            .|       ..|:|.:.:.      :|:|.:.|    ..||||:..:..|:||::|.|.|.|:.|
Human   280 TGQFEIEKSCELLFQMAESVDYDYDVQDTTLDG----LLILPCYGSMTTDQQRRIFLPPPPGIRK 340

  Fly   713 IILSTNIAETSITIDDIVFVIDICKARMKLFTSHN---NLTSYATVWASKTNLEQRKGRAGRVRP 774
            .::||||:.||:|||.|.:|:|....:.   .:||   .|.....|..||:...||.|||||...
Human   341 CVISTNISATSLTIDGIRYVVDGGFVKQ---LNHNPRLGLDILEVVPISKSEALQRSGRAGRTSS 402

  Fly   775 GFCFTLCSRARF-QALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVDAVIEAEV 838
            |.||.:.|:..: |.:.|::.||:.||.|..:.||:|.|.:..:..|  ..|:||....::||..
Human   403 GKCFRIYSKDFWNQCMPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRF--PYLDPPNERLILEALK 465

  Fly   839 LLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLM---AIMASYSSTFSEVFSL 900
            .|.:...:|.:..:|.||..:...|:.|.|...::..|...|.||:   |.|.|..:.|......
Human   466 QLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRPVDP 530

  Fly   901 DIGQRRLANHQK-ALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAK 964
            :..:.....|:: |......:|...:.|..:..:.........:..:..|:.| .|...|....:
Human   531 EYQKEAEQRHRELAAKAGGFNDFATLAVIFEQCKSSGAPASWCQKHWIHWRCL-FSAFRVEAQLR 594

  Fly   965 QQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKEKRKVLTTESKAA 1029
            :.:..|.||:.||:|..           :.|..:|....||.|.:.|:......|...|.:.:.:
Human   595 ELIRKLKQQSDFPKETF-----------EGPKHEVLRRCLCAGYFKNVARRSVGRTFCTMDGRGS 648

  Fly  1030 LLHKTSVNCSNLAVTFPYPFFVFGEKIRTRAVSCKQLSMVSPLQV-----IL-----FGSRKIDL 1084
            .:|....:..:...| ...:.:|.|.:.|..|..:   :|.|::.     :|     |.:..:..
Human   649 PVHIHPSSALHEQET-KLEWIIFHEVLVTTKVYAR---IVCPIRYEWVRDLLPKLHEFNAHDLSS 709

  Fly  1085 AANNIVRVD---NWLNFDIEPELAAKIGALKPALEDL 1118
            .|...||.|   .|.|.:...:|  |.|..|..|:.:
Human   710 VARREVREDARRRWTNKENVKQL--KDGISKDVLKKM 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634
		DEXDc	393..569	CDD:214692	75/182 (41%)
		DEXDc	402..542	CDD:238005	59/146 (40%)
		ATP-synt_B	<584..644	CDD:304375	1/59 (2%)
		Helicase_C	643..772	CDD:278689	50/144 (35%)
		HA2	842..926	CDD:214852	18/87 (21%)
		OB_NTP_bind	974..1078	CDD:285018	20/113 (18%)
DHX40	NP_078888.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		5/15 (33%)
		HrpA	16..770	CDD:224557	217/814 (27%)
		DEAH box	173..176		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	737..779		2/8 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810