Protein Alignment mle and dhx33

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: NP_001093527.4
• Gene: dhx33 / 796505
• ZFINID: ZDB-GENE-131127-77
• Length: 680
• Species: Danio rerio
• Alignment Length: 749
• Identity: 206/749 - (27%)
• Similarity: 331/749 - (44%)
• Gaps: 130/749 - (17%)

  Fly   381 REKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRIS 445
            |..|||...|:::::.:......:..|.||.||||||.||:.:    :|.|....|.:|||||::
Zfish    44 RRHLPIYQSRTQVISQLRQLHSAVFIGETGSGKTTQIPQYLYE----AGIGRQGIIAITQPRRVA 104

  Fly   446 AISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRKL--EAGLRGVSHIIVDE 508
            |||:|.|||.|:..|||..|||:||||.| ..|...:.|.|.|:|||:.  :..|...:.:|:||
Zfish   105 AISLAGRVAEEKKVQLGKLVGYTVRFEDV-TSPETKLKFMTDGMLLREAIGDPLLLRYTVVILDE 168

  Fly   509 IHERDVNSDFLLVIL-----RDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQ 568
            .|||.|::|.|..::     |.:......|.|::||||:|...||:||...|||.:.||..|:|
Zfish   169 AHERTVHTDVLFGVVKAAQRRRLEQNRIPLKVVVMSATMDVDLFSQYFNKSPVLYLEGRQHPIQ- 232

  Fly   569 FFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSES 633
                                                    |.|.|..:..|.|..
Zfish   233 ----------------------------------------IYYTKQPQSDYLQAA---------- 247

  Fly   634 DVSFELLEALLMHIKSKNIPGA--ILVFLPGWNLIFALMKFLQN-TNIFGDTS-QYQILPCHSQI 694
                 |:....:|   :..|.:  |||||.|...|.||.:..:: :....||| ...::|.::.:
Zfish   248 -----LVSIFQIH---QEAPSSHDILVFLTGQEEIEALARTCRDISKHLPDTSGSMTVVPLYASL 304

  Fly   695 PRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASK 759
            |..:|.:||.|.|:|..|:|||||||||||||..|.:|||....:.|.|...:.|...|....||
Zfish   305 PPAQQMRVFLPAPKGSRKVILSTNIAETSITISGIKYVIDTGMVKAKRFNPDSGLEVLAVQRVSK 369

  Fly   760 TNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLLRLGSI--HHFLS 822
            ....||.|||||...|.|:.|.:...|:.|.:...||:.|..|..:.|.:..|.:..:  ..|:|
Zfish   370 AQAWQRAGRAGREDAGSCYRLYTEDEFENLANMTVPEIQRCNLASVVLQLLALGVPDVLNFDFVS 434

  Fly   823 KALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIM 887
            |. .|..:...:|...:|..:...|.:..|||||:.:|..|:|||..|.:::...|.||:.:..:
Zfish   435 KP-SPESMRTAVEQLCILGAVDRKDDHVSLTPLGKKMACFPLEPRFSKTLLISPDFSCAEEILTI 498

  Fly   888 ASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGL 952
            .|..|..|.:::....:..:.:.:|....:: .||:.::   .::|..|:...:.:  :|....:
Zfish   499 ISLLSVDSVLYNPPARRDEVISVRKKFISSE-GDHITLL---NIYRAFKKVSGNKD--WCRENFV 557

  Fly   953 QMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLALLCL--GLYPNIC-V 1014
            ....|.::.:.:.||.|:         |     :...:..:..|.|::....||  ||:.:.. :
Zfish   558 NSRNMGLVGEVRAQLRDI---------C-----IKMNLKLESSVCDLANVRRCLAHGLFMSAAEL 608

  Fly  1015 HKEKRKVLTTESKAALLHKTSVNCSNLAVTFPYPFFVFGEKIRTRAVSCKQLSMVSPLQVILFGS 1079
            ..:...|.....:...:|.:||......|.     .:|.|.:.|.....:.|.::.
Zfish   609 QPDGSYVALDTHQPVSIHPSSVLFQARPVC-----VLFNELLHTSRCYMRDLCLIQ--------- 659

  Fly  1080 RKIDLAANNIVRVDNWLNFDIEPE-LAAKIGALK 1112
                         .:||: :..|| ...|:.|:|
Zfish   660 -------------TDWLH-EAAPEYFRRKLRAIK 679

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684
		DEXHc_DHX9	326..559	CDD:350730	75/184 (41%)
		HrpA	378..>889	CDD:441249	170/520 (33%)
		OB_NTP_bind	1002..1079	CDD:400182	13/79 (16%)
dhx33	NP_001093527.4	None