Protein Alignment mle and ythdc2

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: XP_004910524.1
• Gene: ythdc2 / 779469
• XenbaseID: XB-GENE-5881731
• Length: 1457
• Species: Xenopus tropicalis
• Alignment Length: 1227
• Identity: 363/1227 - (29%)
• Similarity: 527/1227 - (42%)
• Gaps: 373/1227 - (30%)

  Fly   212 NRTVT-ARESGSNKKSASKSCALSLVRQLFHLNVIEPFSGTLKKK-----KDEQLKPYPVKLSPN 270
            ||.:| .:::||...|:..||.|:...:....|:|:.|..|.|::     |.|:...|.::....
 Frog   127 NRCLTLKKKNGSEASSSLMSCTLTQNTKKAVCNLIQRFPLTNKERTELLPKTERGNVYAIEAENR 191

  Fly   271 LINKIDEVIKGLDLPVVNPRNIKIELDG-PPIPLIVNLSRIDSSQQDGEKRQESSVIPWAPPQAN 334
            .|.|....:.|                | |.:|               :||.||
 Frog   192 EIGKTSGCLNG----------------GIPQVP---------------DKRGES----------- 214

  Fly   335 WNTWHACNIDEGELATTSIDDLSMDYERSLRDRRQNDNEYRQFLEFREKLPIAAMRSEILTAIND 399
                                  ..|:                   ||:.||:...:.:|:..|.:
 Frog   215 ----------------------KYDF-------------------FRQSLPVFEKQEDIIRIIKN 238

  Fly   400 NPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDT 464
            |.||:|.|.||.||||||.|:|||:  |...|....|:.|||||::|||||||||.||.|.:|..
 Frog   239 NKVVLIVGETGSGKTTQIPQFILDN--CQKNGLPCRIFCTQPRRLAAISVAERVAAERGEIIGQC 301

  Fly   465 VGYSVRFES-VFPRPYGAILFCTVGVLLRKLEAG---LRGVSHIIVDEIHERDVNSDFLLVILRD 525
            |||.:|.|| |.|:.  .:.|||.|||||.|..|   |..::||||||:||||..|||||..|||
 Frog   302 VGYQIRLESRVSPKT--LLTFCTNGVLLRTLMGGDSTLSAITHIIVDEVHERDRFSDFLLTKLRD 364

  Fly   526 MVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDF---------- 580
            .:..:|.|.:||.||.:|...|.:|||.|||:.:.||.|.|::.|||||::.|.:
 Frog   365 AIQEHPTLKLILSSAALDVNLFIRYFGGCPVIYIQGRPFEVKEMFLEDILRSTGYRNKGMLKYNK 429

  Fly   581 -----------------------VPSAESRRKRKEVEDEEQLLSEDKDEA--------------- 607
                                   .|..:.:|....:::|..:|.:..|.|
 Frog   430 EKQCEEKQKTTLTEWYSAKQKNMKPETQRQRSVPAIKEEYDILDDGGDTAFGQMTEKDANCLEPW 494

  Fly   608 ---EINYNKVC---------EDKYSQ-----KTRNA----------------------------- 626
               ||:   .|         :|.::|     .|.|.
 Frog   495 LIKEID---ACLSDIWLYRDKDAFAQLFHLISTENVSVDYRHSETSATPLMVAAGQGFLSHVEQL 556

  Fly   627 ---------------MAM-------------LSES---------------------DVSF---EL 639
                           ||:             |.||                     |:|.   ||
 Frog   557 ISMGANIQSKASNGWMALDWAKHFGQTEVVDLLESYSASLETEDLDENTLVQSDGNDLSIEDREL 621

  Fly   640 LEA-------------LLMHIKSKNI-----PGAILVFLPGWNLIFALM-KFLQNTNIFGDTSQ- 684
            |:|             |:||:.. ||     .||||:||||::.|..|. :.|.:...|.|.:|
 Frog   622 LKAYHHSFDDEKVDLDLIMHVLF-NICQITDTGAILIFLPGYDEIVGLRDRILLDDKRFADNAQR 685

  Fly   685 YQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNL 749
            |.:...||.:...:|:||.:..|.|:.||||||||||||||::|:|||||..|.:.|.|.:.||:
 Frog   686 YHVFMLHSNMQTSDQKKVLKLPPAGIRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNNV 750

  Fly   750 TSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLLRL 814
            |....||.||.:..||||||||.|||.||.|.|:.|||.:.:..|||:.|.||||:.|..|||..
 Frog   751 TMLKMVWISKASAIQRKGRAGRCRPGICFRLFSKLRFQNMLEFQTPELLRIPLHELCLHTKLLVP 815

  Fly   815 GS--IHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAV 877
            .:  :..||.||.||||...|..|..:|:.:..:|..::||.:|..||.||:||.||||::...:
 Frog   816 INCPVADFLMKAPEPPPALIVRNAVQMLKTIDAMDNWEDLTEIGHHLADLPVEPHLGKMVLCAVI 880

  Fly   878 FGCAD---LMAIMASYSSTFSEVFSLDIGQRRLAN--HQKALSGTKCSDHVAMIVASQMWRREKQ 937
            ..|.|   .:|...:|...|  |......|:|.|.  .::..:|| .|||:|::.|.|.|::.|.
 Frog   881 LKCLDPILTIACTLAYRDPF--VLPSQASQKRAAMLCRKRFTAGT-FSDHMALLRAFQAWQKAKS 942

  Fly   938 RGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSL- 1001
            .|  .|..||:...|..:||.:|...:.|||..|:.:||         |..|..||  :.||::
 Frog   943 DG--WERAFCEKNFLSQATMEIIIGLRTQLLGQLRASGF---------VRARGGGD--IRDVNIN 994

  Fly  1002 --------ALLCLGLYPNICVHKEKRKVLTT--ESKAALLHKT------------SVNCSNLAV- 1043
                    |.|..|:|||: :|.::..::.:  :.|....|.:            |.||...||
 Frog   995 SENWAVVKAALLSGMYPNL-IHVDRENMVLSGVKEKRVRFHPSSALSEPQYKKIPSANCQAEAVQ 1058

  Fly  1044 TFPYPFFVFGEKIRT-RAVSCKQLSMVSPLQVILF-GSRKIDLAA--------------NN---- 1088
            ..|..:.|:.|..|: |..:.|..|:|:|:..:|| |..::..:|              |:
 Frog  1059 ALPTDWLVYDEMTRSHRIANIKCCSVVTPVTAVLFAGPARLPSSALKEPSSFQVGDGIPNDSSDS 1123

  Fly  1089 -----------IVRVDNWLNFDIEPELAAKIGALKPALEDLITVACDNPSDILRLEEPYAQL--- 1139
                       .:::|.||:|.::||.|..:..|:...:.|.......||      :|::|:
 Frog  1124 EMEDRNTFTLATLKLDEWLHFRLDPEAAGLLFQLRQKWQSLFLRRIQAPS------KPWSQVDEA 1182

  Fly  1140 -VKVVKDLCVKSAGDFGLQRESGILPHQSRQFSDGGGPPKRGRFE-----TGRFTNS 1190
             ::|:..:........|||:.|||           |..|:....|     :||..||
 Frog  1183 TIRVIIAVLNTEEQSAGLQQPSGI-----------GQRPRTLNCEDHLLTSGRINNS 1228

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684	9/29 (31%)
		DEXHc_DHX9	326..559	CDD:350730	96/236 (41%)
		HrpA	378..>889	CDD:441249	244/685 (36%)
		OB_NTP_bind	1002..1079	CDD:400182	25/93 (27%)
ythdc2	XP_004910524.1	DEXHc_YTHDC2	223..398	CDD:350745	93/178 (52%)
		ANK repeat	535..567	CDD:293786	0/31 (0%)
		ANKYR	<539..>606	CDD:440430	5/66 (8%)
		ANK repeat	569..600	CDD:293786	5/30 (17%)
		OB_NTP_bind	1001..1096	CDD:400182	25/95 (26%)
		YTH	1317..1446	CDD:410979
		R3H_DEXH_helicase	76..134	CDD:100077	3/6 (50%)
		HrpA	222..>1040	CDD:441249	287/842 (34%)