Protein Alignment mle and Tdrd9

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: NP_083332.1
• Gene: Tdrd9 / 74691
• MGIID: 1921941
• Length: 1383
• Species: Mus musculus
• Alignment Length: 780
• Identity: 246/780 - (31%)
• Similarity: 383/780 - (49%)
• Gaps: 115/780 - (14%)

  Fly   384 LPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRISAIS 448
            |||...:.|:::.|..|.||||.|.||.||:||:.||:||.|  :.:..:.||.|||||:|.|.|
Mouse   134 LPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHY--TQRSAFCNIVVTQPRKIGASS 196

  Fly   449 VAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRKLEA--GLRGVSHIIVDEIHE 511
            :|..:::||...||..|||.|..|.:.... ..:::.|.||||:|:.:  .|...:||.:||:||
Mouse   197 IARWISKERSWTLGGLVGYQVGLEKIATED-TRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHE 260

  Fly   512 RDVNSDFLLVILRDMVDTYPD-LHVILMSATIDTTKFSKYFGI--------CPVLEVPGRAFPVQ 567
            |....||||:::|.::.|... :.|:||||||:..:|:.||.:        ..|.||.|:...::
Mouse   261 RTEEMDFLLLVVRKLLRTNSRFVKVVLMSATINCKQFADYFAVPVQNKMNPAYVFEVEGKPHAIE 325

  Fly   568 QFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCED----KYSQKTRNAMA 628
            :::|.|:         ............||.::::|..|..::..::.:|    :...||.:...
Mouse   326 EYYLNDL---------GHIYHSGLPYRLEEPVITKDVYEVAVSLIQMFDDLDMKESGNKTWSGAQ 381

  Fly   629 MLSESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQNTNIFGDTSQYQILPCHSQ 693
            .:||.                    .::||||||...|..:.:.|  ||:.  ..:.|:.|.||.
Mouse   382 FVSER--------------------SSVLVFLPGLGEINYMHELL--TNMI--HKRLQVYPLHSS 422

  Fly   694 IPRDEQRKVF-EPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWA 757
            :..:||..|| .||| |..||||||||||:|:|:.|:.:|||.|..|..:.....|..|....||
Mouse   423 VTLEEQNNVFLSPVP-GYRKIILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWA 486

  Fly   758 SKTNLEQRKGRAGRVRPGFCFTLCSRARF-QALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHFL 821
            |||:.:|||||||||..|:|:.|..|..: .|:.|::.|||.|.||....|.:|||.:|.....|
Mouse   487 SKTSCDQRKGRAGRVSKGYCYRLIPRDFWDSAIPDHVVPEMLRCPLGSTILKVKLLDMGEPRALL 551

  Fly   822 SKALEPPPVDAVIEAEVLLREMRCL-------DAN---DELTPLGRLLARLPIEPRLGKMMVLGA 876
            :.||.||.:..:....:||:|:..|       |.|   .|||.|||:||:||:..:|||::|||.
Mouse   552 ATALSPPSLSDIERTILLLKEVGALAVSGQREDENPHDGELTFLGRVLAQLPVSQQLGKLVVLGH 616

  Fly   877 VFGCAD---LMAIMASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQR 938
            ||||.|   ::|...|..:.|:..|...:...|...|   .||:..||.:|::.|.:.|:..:||
Mouse   617 VFGCLDECLIIAAALSLKNFFTMPFRQHLDGYRNKVH---FSGSSRSDCLALVEAFRAWQACRQR 678

  Fly   939 GEHMEAR-FCDWKGL---QMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLD- 998
            ||....: ..||..|   |:..:..:.:..::|.:.:.|            .:..:....||||
Mouse   679 GELRRPKDELDWGRLNYIQIKRIREVAELYEELKNRISQ------------FNMFVGPHHPVLDQ 731

  Fly   999 --------VSLALLCLGLYPNICVHKEKRKVLTTESKAALLHKTSVNCSNLAVTFPYPFFVFGEK 1055
                    :...:|....|||.....:..:.:.....|....||:|...::.   ||.|..: ::
Mouse   732 EYPYKQRFILQVVLAGAFYPNYFTFGQPDEEMAVRELAGKDPKTTVVLKHIP---PYGFLYY-KQ 792

  Fly  1056 IRTRAVSCKQLSMVSPLQVILFGSRK--IDLAANNIVRVDNWLNFDIEP--ELAAKIGALKPALE 1116
            :::....|.|      ::.|:|...|  ::.:.|...|      |...|  .||.|:..||.:||
Mouse   793 LQSLFRQCGQ------VKSIVFDGAKAFVEFSRNPTER------FKTLPAVNLAVKMSQLKVSLE 845

  Fly  1117  1116
            Mouse   846  845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684
		DEXHc_DHX9	326..559	CDD:350730	73/185 (39%)
		HrpA	378..>889	CDD:441249	193/534 (36%)
		OB_NTP_bind	1002..1079	CDD:400182	15/76 (20%)
Tdrd9	NP_083332.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	35..82
		HrpA	132..>706	CDD:441249	213/611 (35%)
		DEAD-like_helicase_N	134..317	CDD:475120	73/185 (39%)
		DEAH box. /evidence=ECO:0000269|PubMed:28633017	256..259		2/2 (100%)
		Tudor_TDRD9	906..1006	CDD:410502