Protein Alignment mle and dhx38

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: XP_002937626.2
• Gene: dhx38 / 734019
• XenbaseID: XB-GENE-990308
• Length: 1212
• Species: Xenopus tropicalis
• Alignment Length: 1174
• Identity: 292/1174 - (24%)
• Similarity: 482/1174 - (41%)
• Gaps: 294/1174 - (25%)

  Fly    28 KNRQRFLCEVRVEPNTYIGVGNSTNK-----KDAEKNACRDFVNYLVRVGKLNTNDVPADAGASG 87
            :||||.  ..|.|...|....:...:     ::.|..:||              |....|:|:..
 Frog   124 RNRQRE--RERREHGVYASSKDDRQRRKERGREREDRSCR--------------NRSERDSGSER 172

  Fly    88 GGPRTGLEGAGMAGGSGQQKRVFDGQSGPQDLGEAYRPL--NHDGGDGGNRYS--------VIDR 142
            .|.|:..|       |.:.|        |:|.....|..  ..|.|.|.::.|        ..:|
 Frog   173 SGRRSEPE-------SPRHK--------PRDASTPSRSSWEEDDSGYGSSQRSQWESPSPAPSNR 222

  Fly   143 IQEQRDMNEAEAFDVNAAIHGNWTIEN------------AKERLNI----------YKQTNNIRD 185
            ..|:...:|.|:.....:..|.::.|:            |.:|.::          .||.:   |
 Frog   223 DSEKSHRSERESSRRERSERGRYSEESPLPTPSYKYNEWASDRRHLGSTPRLSQGRGKQDS---D 284

  Fly   186 DYKYTPVGPEHARSF-----LAELSIYV---------PALNRT----VTARESGSNKKSASKSCA 232
            |.|...:..|..|.:     .|:...|:         .||..|    |..||....|:::.:..|
 Frog   285 DDKINFMSEEEQRQWEDDQRQADRDWYMMDEGFDESHNALTSTSEDYVKKREQQLQKQTSKRVSA 349

  Fly   233 LSLVRQLFHLNVIEPF-------SGTLKK-KKDEQLKPYPVKLSPNLINKIDEVIKGLDLPVVNP 289
            ..  ||:...|  |.:       ||.::: :.||..:       .:...|:..::..|..|.::.
 Frog   350 QR--RQINEDN--ERWETNRMLTSGVVQRLEVDEDFE-------EDNAAKVHLLVHNLVPPFLDG 403

  Fly   290 RNIKIELDGPPIPL--------IV-----NLSRIDSSQQDGEKRQESSVIPWAPPQANWNTWHAC 341
            |.:..:...|.||:        |:     .|.|....|::.:|.|..          :|
 Frog   404 RIVFTKQPEPVIPVRDATSDLAIIARKGSQLVRKHREQKERKKAQHK----------HW------ 452

  Fly   342 NIDEGELATTSIDDL------------------SMDYERS------LRDRRQNDNEY---RQFLE 379
                 |||.|.:.|:                  ::||:..      :|:|.:..:::   :..:|
 Frog   453 -----ELAGTKLGDIMGVKKQVDEPDKPIAEDGAVDYKAEQKFADHMRERSEASSDFSRKKSLME 512

  Fly   380 FREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRI 444
            .|:.|||.|::.|:||.|.||.:||:.|.||.|||||:.||:.:|    |...|..|..|||||:
 Frog   513 QRQYLPIFAVQQELLTIIRDNSIVIVVGETGSGKTTQLTQYLHED----GYTDYGMIACTQPRRV 573

  Fly   445 SAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRKL--EAGLRGVSHIIVD 507
            :|:|||:||:.|....||:.|||::|||...... ..|.:.|.|:|||:.  ||.|...|.:|:|
 Frog   574 AAMSVAKRVSEEMQVSLGEEVGYAIRFEDCTSEK-TLIKYMTDGILLRECLREADLDHYSAVIMD 637

  Fly   508 EIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLE 572
            |.|||.:|:|.|..:||::|....||.:|:.|||:|..||:.:||..|:..:|||.|||
 Frog   638 EAHERSLNTDVLFGLLREVVTRRSDLKLIVTSATMDADKFATFFGNVPIFYIPGRTFPV------ 696

  Fly   573 DIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSF 637
                                               :|.::|..::.|               |..
 Frog   697 -----------------------------------DILFSKTPQEDY---------------VEA 711

  Fly   638 ELLEALLMHIKSKNIPGAILVFLPGWNLIFALM-KFLQNTNIFGDTSQYQILPCHSQIPRDEQRK 701
            .:.:||.:|:  ....|.||:|:||...|.... :.::............:||.:||:|.|.|.|
 Frog   712 AVKQALQIHL--SGAAGDILIFMPGQEDIEVTSDQIVERLEELDSAPPLAVLPIYSQLPSDLQAK 774

  Fly   702 VFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRK 766
            :|:..|:||.|.|::|||||||:|:|.|:||||....::|:|.....:.:......|:.|..||.
 Frog   775 IFQKAPDGVRKCIVATNIAETSLTVDGIMFVIDSGYCKLKVFNPRIGMDALQIYPISQANANQRS 839

  Fly   767 GRAGRVRPGFCFTLCSRARFQ-ALEDNLTPEMFRTPLHEMALTIKLLRLGS--IHHFLSKALEPP 828
            |||||..||.|:.|.:::.:: .|.....||:.||.|..:.|.:|.|.:..  :.||    ::||
 Frog   840 GRAGRTGPGQCYRLYTQSAYKNELLHTTVPEIQRTNLSNVVLLLKSLGVQDLLLFHF----MDPP 900

  Fly   829 PVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSST 893
            |.|.::.:...|..:..||....|||.|||:...|::|.|.||:::....||:..:.|:.|..|.
 Frog   901 PEDNMLNSMYQLWILGALDNTGALTPTGRLMVEFPLDPALSKMLIVSCDMGCSSEILIVVSMLSV 965

  Fly   894 FSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMN 958
             ..:|....|:...::..:.......|||:..:.....|     :..:..:.:|:...:....|.
 Frog   966 -PAIFYRPKGREEESDQVREKFAVPESDHLTYLNVFLQW-----KNNNYSSGWCNQHFIHAKAMR 1024

  Fly   959 VIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLALLC------------LGLYPN 1011
            .:.:.:.||.|:          |:|..:.....|.|  .|:....:|            :|.|.|
 Frog  1025 KVREVRAQLKDI----------MVSQRMSLSSCGSD--WDIVRKCICAAYFHQAARLKGIGEYVN 1077

  Fly  1012 ICVHKEKRKVLTTESKAALLHKTSVNCSNLAVTFPYPFFVFGEKIRT--------RAVSCKQLSM 1068
            :           .......||.||   |...:.:...:.|:.|.:.|        .||..:.|:.
 Frog  1078 V-----------RTGMPCHLHPTS---SLFGMGYTPDYIVYHELVMTTKEYMQCVTAVDGEWLAE 1128

  Fly  1069 VSPL 1072
            :.|:
 Frog  1129 LGPM 1132

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683	10/46 (22%)
		DSRM_DHX9_rpt2	167..241	CDD:380684	22/113 (19%)
		DEXHc_DHX9	326..559	CDD:350730	92/261 (35%)
		HrpA	378..>889	CDD:441249	177/516 (34%)
		OB_NTP_bind	1002..1079	CDD:400182	16/91 (18%)
dhx38	XP_002937626.2	HrpA	517..>1175	CDD:441249	209/715 (29%)