Protein Alignment mle and dhx37

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: XP_002944206.3
• Gene: dhx37 / 734015
• XenbaseID: XB-GENE-986494
• Length: 1147
• Species: Xenopus tropicalis
• Alignment Length: 914
• Identity: 229/914 - (25%)
• Similarity: 367/914 - (40%)
• Gaps: 260/914 - (28%)

  Fly   379 EFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYAN----IYVT 439
            |.|.||||.|....|:.||.:||||::.|.||.|||||:.|::.       :.||.:    |.:|
 Frog   241 EARLKLPILAEEQVIMEAIKENPVVVLCGETGSGKTTQVPQFLY-------EAGYGSENDVIGIT 298

  Fly   440 QPRRISAISVAERVARE-RCEQLGDTVGYSVRFESVFPRPYGAI------LFCTVGVLLRKLEAG 497
            :|||::||::::|||.| ...|  ..:.|.:|:|       |.:      .|.|.||||::::..
 Frog   299 EPRRVAAIAMSQRVALEMNLPQ--SVISYQIRYE-------GNVSNETKTKFMTDGVLLKEIQKD 354

  Fly   498 --LRGVSHIIVDEIHERDVNSDFLLVILRDMVDTY----PDLHVILMSATI---DTTKFSKYFGI 553
              |.....:|:||.|||.|.:|.|:.:|..:|...    ..|.:|:||||:   |.|:..:.|.:
 Frog   355 FLLTRYRVVIIDEAHERSVYTDILIGLLSRIVPLRAKKGSPLKLIIMSATLRIEDFTENKRLFPV 419

  Fly   554 -CPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCED 617
             .||::|..|.|||...|                 .||..:|          |.|...|.|||:
 Frog   420 PPPVIKVDARQFPVTVHF-----------------NKRTPLE----------DYAGECYRKVCK- 456

  Fly   618 KYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIP-GAILVFLPGWNLIFALMKFLQNTNIF-- 679
                                       :|   :.:| |.||:||.|...:.:|.:.|:.|..|
 Frog   457 ---------------------------IH---RMLPAGGILIFLTGQAEVHSLCRRLRKTFPFCG 491

  Fly   680 ----------------------------------------------------------------- 679
                                                                             
 Frog   492 RNYHNATEDEDSQEAVRRFKKSRPKKTMNLPKIDLASYSAQPLDEGDEDREAADDEEDGSGSDLD 556

  Fly   680 ---GDTSQYQ-----------ILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIV 730
               ||....:           :||.:|.:..::|.|||.|.|.|....:::||:||||:||..|.
 Frog   557 IDLGDEGAEEDEKADSSLPLFVLPLYSLLAPEKQAKVFRPPPPGTRLCVVATNVAETSLTIPGIK 621

  Fly   731 FVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTP 795
            :|:|..|.:.:.:.....::|:...|.|:.:..||.|||||..||.|:.|.|.|.|...|....|
 Frog   622 YVVDCGKVKKRYYDKVTGVSSFRVDWTSQASANQRAGRAGRTEPGHCYRLYSSAVFADFEQFSPP 686

  Fly   796 EMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVDAVIEAEVLLREMRCLD-------AND--- 850
            |:.|.|:.::.|.:|.|.:..:.:|....  ||..||:|.||.||..:..|.       .||
 Frog   687 EITRRPVEDLVLQMKDLNIEKVVNFPFPT--PPSADALIAAEELLISLGALQEPPKTGRLNDLQK 749

  Fly   851 -----ELTPLGRLLARLPIEPRLGKMMVLGAVFGCAD-LMAIMASYSSTFSEVFSLDIGQRRLAN 909
                 .:||||:.:|..|:.||..||:.||....|.. ::.|:|  :.|..|:|. ::.:..:::
 Frog   750 AKLSSPITPLGKTMASFPVAPRYAKMLALGRQHECLPYVITIVA--AMTVRELFE-EVDRPAVSD 811

  Fly   910 HQK-ALSGTKCSDHVAMIVASQMWRRE---KQRGEHM--------------EARFCDWKGLQMST 956
            .:| .|.|.|    ..::...::|..:   ::.|:.|              |.:||:..||:...
 Frog   812 EEKELLKGKK----ARVLQMQRIWAGQGSAQKLGDLMVMLGAVGACEYSGLEPKFCERNGLRFKA 872

  Fly   957 MNVIWDAKQQLLDLLQQAGFPEECMISH-EVDERIDGDDPVLDVSLA----LLCLGLYPNICVHK 1016
            |..|...:.||...:...     |..:| .:|.::   :|..:..:.    ::..||..:|....
 Frog   873 MLEIRRLRGQLTTTVNSL-----CPDTHLYLDSKM---NPPTESQVTYLRQIVMSGLGDHIARRI 929

  Fly  1017 EKRKVLTTE----SKAALLHKTSVNCSNLAVTFPYP-FFVFGEKIRTRAVSCKQLSMVSPLQVIL 1076
            .:.::|..:    .|..||.:......|.|:....| |.|:.|.:.|..:..|.:|.:.
 Frog   930 RQEELLDEKWRNAYKTPLLEEPVFIHPNSALFRQLPDFVVYQEIMETTKMYMKGVSAIE------ 988

  Fly  1077 FGSRKIDLAANNIVRVDNWLNFDIEPELAAKIGALKPALEDLITVACDNPSDILRLEEPYAQLVK 1141
              :..|.:.........|.|. |..|...::.|.:|          |..||...|:.   .||..
 Frog   989 --AEWIPILLPQYCHFGNPLE-DPPPFYCSETGRVK----------CHRPSTFYRVG---WQLPA 1037

  Fly  1142 VVKD 1145
            ||.|
 Frog  1038 VVAD 1041

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684
		DEXHc_DHX9	326..559	CDD:350730	70/200 (35%)
		HrpA	378..>889	CDD:441249	173/628 (28%)
		OB_NTP_bind	1002..1079	CDD:400182	16/85 (19%)
dhx37	XP_002944206.3	PTZ00108	<59..222	CDD:240271
		HrpA	246..>997	CDD:441249	211/849 (25%)