DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and dhx9

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	XP_002937403.1	Gene:	dhx9 / 733723	XenbaseID:	XB-GENE-967775	Length:	1257	Species:	Xenopus tropicalis

Alignment Length:	1310	Identity:	663/1310 - (50%)
Similarity:	886/1310 - (67%)	Gaps:	85/1310 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DIKSFLYQFCAKSQIEPKFDIRQTGPKNRQRFLCEVRVEPNTYIGVGNSTNKKDAEKNACRDFVN 66
            |||:|||.:|.|.::.|.::||..|.|.||:|:|||||:...|.|:|||||||||:.||.|||||
Frog     3 DIKNFLYAWCGKKKLTPNYEIRAAGNKMRQKFMCEVRVDGFNYTGMGNSTNKKDAQTNAARDFVN 67

  Fly    67 YLVRVGKLNTNDVP---ADAGASGGGPRTGLEG-AGMAGGS-----GQQKRVFDGQSGPQDLGEA 122
            |||||.::.:::||   |:.|.|..|.....|| :|..||.     ..|....|  :.|......
Frog    68 YLVRVKEMKSDEVPSLGAEQGDSIDGAPVKSEGFSGPTGGPLPPHLSLQAETSD--AAPMRANTG 130

  Fly   123 YRPLNHDGGDGGNRYSVIDRIQEQRDMNEAEA------FDVNAAIHGNWTIENAKERLNIYKQTN 181
            ..|..:.||....|.:.:.....:||..||:|      .|:||.:|||||:||||.|||.:.|..
Frog   131 CNPPAYGGGAQWERGANLKDYYAKRDEQEAQATLESEEVDLNAGLHGNWTLENAKARLNQFFQKE 195

  Fly   182 NIRDDYKYTPVGPEHARSFLAELSIYVPALNRTVTARESGSNKKSASKSCALSLVRQLFHLNVIE 246
            ..:.:|||:.|||:|.|||:||:::||..|.|.:||||.|||||.|::|||||:||||:||:|||
Frog   196 KTQGEYKYSQVGPDHNRSFIAEMTLYVKQLGRRITAREHGSNKKLAAQSCALSIVRQLYHLSVIE 260

  Fly   247 PFSGTLKKKKDEQLKPYPVKLSPNLINKIDEVIK--GLDLPVVNPRNIKIELDGPPIPLIVNLSR 309
            |:||..|||:.|.::||.|.|:|:::.::...|:  |::|| ..|::       |..|:.:||.:
Frog   261 PYSGLTKKKEGEAVEPYQVNLNPDVVKQLQSTIQELGIELP-YPPQD-------PSQPVSLNLGK 317

  Fly   310 I---DSSQQDGEKRQESSVIPWAPPQANWNTWHACNIDEGELATTSIDDLSMDYERSLRDRRQND 371
            :   :.||    |:..|.|:||:|||.|||.|.:.|||||.||....:.:|.:.:.......|:.
Frog   318 LVHFEPSQ----KQSHSGVVPWSPPQENWNPWTSSNIDEGPLAFAPQEQISAELKNEHMYHMQDP 378

  Fly   372 NEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYANI 436
            | .:|.|..||.||:.....||:.|::::|||||||.||||||||:.|||||:.|.:.:....||
Frog   379 N-MKQVLIDRESLPVKKFEEEIMHAVHNSPVVIIRGATGCGKTTQVPQYILDECIRNDRAAQCNI 442

  Fly   437 YVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRKLEAGLRGV 501
            .|||||||||:|||||||.||.|::|.:.|||||||||.|||:.::|||||||||||||||:||:
Frog   443 VVTQPRRISAVSVAERVAFERGEEIGKSCGYSVRFESVLPRPHASMLFCTVGVLLRKLEAGIRGI 507

  Fly   502 SHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPV 566
            ||:|||||||||:|:|||||:|||::..:||:.||||||||||:.|.:||..||::||.||.|||
Frog   508 SHVIVDEIHERDINTDFLLVVLRDVIQAFPDIRVILMSATIDTSMFCEYFFNCPIIEVFGRTFPV 572

  Fly   567 QQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLS 631
            |::||||.||||.|:|  ..|.|:|:.:||     |..|:.|.|.|.||.|.|..:||.:|:.||
Frog   573 QEYFLEDCIQMTQFIP--PPRDKKKKDKDE-----EGGDDEETNCNLVCGDDYGPETRRSMSQLS 630

  Fly   632 ESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQNTNIFGDTSQYQILPCHSQIPR 696
            |.:...||:||||.:|::.|:|||:||||||||||:|:.|.|:....||..| |.|||.||||||
Frog   631 EKETPLELIEALLKYIETLNVPGAVLVFLPGWNLIYAMQKHLEMNPHFGSHS-YCILPLHSQIPR 694

  Fly   697 DEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTN 761
            |||||||:|||:|:.|:|||||||||||||:|:|:|||.||.::||||||||:|:||||||||||
Frog   695 DEQRKVFDPVPDGIIKVILSTNIAETSITINDVVYVIDSCKQKVKLFTSHNNMTNYATVWASKTN 759

  Fly   762 LEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHFLSKALE 826
            |||||||||||||||||.|||||||:.||.:||||:|||||||:||:|||||||.|..|||||:|
Frog   760 LEQRKGRAGRVRPGFCFHLCSRARFERLETHLTPEIFRTPLHEVALSIKLLRLGGIGQFLSKAIE 824

  Fly   827 PPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYS 891
            |||:|||||||..|||:..||:|||||||||:||:|||||||||||::|.:|...|.:..: |.:
Frog   825 PPPLDAVIEAEHTLRELDALDSNDELTPLGRILAKLPIEPRLGKMMIMGCIFYVGDALCTI-SAA 888

  Fly   892 STFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMST 956
            :.|.|.|..:  .|||....:..:|.:.|||||::...|.|...:..||..|.|||:.|.|.|:|
Frog   889 TCFPEPFISE--GRRLGYVHRNFAGNRFSDHVALLSVFQAWDDARMGGEEAETRFCEHKRLNMAT 951

  Fly   957 MNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKEKRKV 1021
            :.:.|:||.||.::|..:||||||:::...:.  .|.|..|||.::||..|:|||:|.||||||:
Frog   952 LRMTWEAKVQLKEILVNSGFPEECLMTQVFNN--TGPDNNLDVVISLLAFGVYPNVCYHKEKRKI 1014

  Fly  1022 LTTESKAALLHKTSVNC--SNLAVTFPYPFFVFGEKIRTRAVSCKQLSMVSPLQVILFGSRKIDL 1084
            ||||.:.||:||:||||  ||..:.:|.|||||.|||||||:|.|.::||||||::||.|:|: :
Frog  1015 LTTEGRNALIHKSSVNCPFSNQDLKYPSPFFVFSEKIRTRAISAKGMTMVSPLQLLLFASKKV-M 1078

  Fly  1085 AANNIVRVDNWLNFDIEPELAAKIGALKPALEDLITVACDNPSDILRLEEPYAQLVKVVKDLCVK 1149
            :....:.:|:|:...:..:.:|.|.||:.|||.|:......|..:.:|:....:::.:::  .:.
Frog  1079 SDGEFILLDDWIRLSLPHDESACITALRAALEALVVEVTKEPEILSQLDPVNEKMLNMIR--LIS 1141

  Fly  1150 SAGDFGLQRESGILPHQSRQFSDGGGPPKRGRFETGRFTNSSF-GRRGNGRTFGGGYGNNGGGYG 1213
            .....|:....|     :.:|.||..|||..||::|      | |.||.|  :.|||.:.|||:
Frog  1142 KPSTAGISLVMG-----NSRFGDGPRPPKMARFDSG------FQGNRGRG--YHGGYNSGGGGF- 1192

  Fly  1214 NNGGGYGNIGGGYGNNA--GGY---GNNGGY--GNNGGGYRNNGGGYGNNGGGYGNKRGGFGDSF 1271
             .|.||....||.|...  |||   |..|.|  ||.|||:|   |||.:.||      ||:|.::
Frog  1193 -RGSGYQGFRGGRGGGGPWGGYQGGGFRGNYRGGNQGGGFR---GGYQSRGG------GGYGGNY 1247

  Fly  1272 ESNRGSGGGF 1281
            :...|..|||
Frog  1248 QGRGGFRGGF 1257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634	37/63 (59%)
		DSRM	170..240	CDD:214634	40/69 (58%)
		DEXDc	393..569	CDD:214692	119/175 (68%)
		DEXDc	402..542	CDD:238005	99/139 (71%)
		ATP-synt_B	<584..644	CDD:304375	24/59 (41%)
		Helicase_C	643..772	CDD:278689	93/128 (73%)
		HA2	842..926	CDD:214852	41/83 (49%)
		OB_NTP_bind	974..1078	CDD:285018	60/105 (57%)
dhx9	XP_002937403.1	DSRM_DHX9_rpt1	3..71	CDD:380683	41/67 (61%)
		DSRM_DHX9_rpt2	181..255	CDD:380684	43/73 (59%)
		DEXHc_DHX9	333..565	CDD:350730	137/232 (59%)
		HrpA	345..>1054	CDD:224557	427/722 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2546
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1039
Inparanoid	1	1.050	1227	1.000	Inparanoid score	I188
OMA	1	1.010	-	-		QHG45656
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	1	1.000	-	-		FOG0006547
OrthoInspector	1	1.000	-	-		oto105184
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2487
SonicParanoid	1	1.000	-	-		X4785
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.110