DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and Dhx34

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_001272860.1	Gene:	Dhx34 / 71723	MGIID:	1918973	Length:	1145	Species:	Mus musculus

Alignment Length:	921	Identity:	260/921 - (28%)
Similarity:	403/921 - (43%)	Gaps:	239/921 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   352 SIDDLSMDYERSLR--------DRR-----------QNDNEYRQ----FLEFREK---------- 383
            ::.||.:.|:...|        |.|           :..:|:|:    :|:|::|
Mouse    94 ALADLPLTYDPRYRINLSILSPDTRGRHGPGRGLPPERVSEFRRALLHYLDFQQKQAFGRLVKLQ 158

  Fly   384 -----LPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRR 443
                 ||||...:.||..:.::.||::.|:|||||:||:.||:|       ..|::::..|||||
Mouse   159 RERAALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVPQYLL-------AAGFSHVACTQPRR 216

  Fly   444 ISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGA-ILFCTVGVLLRKL--EAGLRGVSHII 505
            |:.||:|:||..|...|.|..|||.:||||.  |.... |:|.|||:|||::  |..|.....:|
Mouse   217 IACISLAKRVGFESLSQYGSQVGYQIRFEST--RSAATKIVFLTVGLLLRQIQREPSLPQYQVLI 279

  Fly   506 VDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFF 570
            |||:|||.:::||||.:|:.::...|||.||||||||:.:.||.||...||::||||.||:...:
Mouse   280 VDEVHERHLHNDFLLGVLQRLLPQRPDLKVILMSATINISLFSSYFSHAPVVQVPGRLFPITVVY 344

  Fly   571 LEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAE-INYNKVCEDKYSQKTRNAMAMLSESD 634
                               :.:..|:....||..|... :...:..::||..:.|
Mouse   345 -------------------QPQEADQTASKSEKLDPRPFLRVLEAIDNKYPPEER---------- 380

  Fly   635 VSFELLEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQ 699
                               |.:||||.|...|..::...|.....  |.::.:||.||.:...:|
Mouse   381 -------------------GDLLVFLSGMAEITTVLDAAQAYASL--TQRWVVLPLHSALSVSDQ 424

  Fly   700 RKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQ 764
            .|||:..|.||.|.||||||||||:|||.|.||:|..|.:...:.....|......|.|:.:.||
Mouse   425 DKVFDVAPAGVRKCILSTNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQEFWISQASAEQ 489

  Fly   765 RKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPP 829
            |||||||..||.|:.|.:.:.:.|......||:.|..|..:.|.:|.:.:|....|  ..:||||
Mouse   490 RKGRAGRTGPGVCYRLYAESDYDAFAPYPVPEIRRVALDALVLQMKSMSVGDPRTF--PFIEPPP 552

  Fly   830 VDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCAD-LMAIMASYS-- 891
            ..:|..|.:.|:|...||:::.|||:|.|||:||::..:|||::||::|..|: ::.|.|:.|
Mouse   553 PASVETAILYLQEQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGSMFSLAEPVLTIAAALSVQ 617

  Fly   892 --STFSEVFSLD--IGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGL 952
              .|.|...:||  ..:|.|.:.|        .|...:......|.:.|........::|..:|:
Mouse   618 SPFTRSAQSNLDCATARRPLESDQ--------GDPFTLFNVFNAWVQVKSERSGNSRKWCRRRGV 674

  Fly   953 QMSTMNVIWDAKQQLLDLLQQAG------------------------------------------ 975
            :...:..:.:.::|..:||:..|
Mouse   675 EEHRLYEMANLRRQFKELLEDHGLLSGAQVVAPGDSYSRLQQRRERRALHQLKRQHEEGGGRRRK 739

  Fly   976 ---FPEECMISHEVD------ERIDGDDPVLDV------------------------SLALLCL- 1006
               ..|:...|.|.|      :|.|..| :.||                        .||||.|
Mouse   740 VLRLQEDGCSSDEEDREGSTSQRADSVD-IQDVKFKLRHNLEQLQAAASSAQDLTRDQLALLKLV 803

  Fly  1007 ---GLYPNICV-------HKEKRKVLTTESK-AALLHKTSVNCSNLAVTFPYPFFVFGEKIRTR- 1059
               ||||.:.|       .|:..::..|::| ..:||.|.|..::     |......|::...:
Mouse   804 LGRGLYPQLAVPDAFNSGRKDSDQIFHTQAKQGTVLHPTCVFANS-----PEVLHTQGQEASGQE 863

  Fly  1060 -------AVSCKQ--LSMVS----------------PLQVILFGSRKIDLAAN-NIVRVDNWLNF 1098
                   .:|||.  |:.||                .||.:|..||.||...: :.:..|.||..
Mouse   864 GSQDGRDQMSCKHQLLAFVSLLETNKPYLVNCVRIPALQSLLLFSRSIDTNGDCSRLVADGWLEL 928

  Fly  1099 DI-EPELAAKI 1108
            .: :.|.|.::
Mouse   929 QLADSESAVRL 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634
		DEXDc	393..569	CDD:214692	83/178 (47%)
		DEXDc	402..542	CDD:238005	67/142 (47%)
		ATP-synt_B	<584..644	CDD:304375	7/60 (12%)
		Helicase_C	643..772	CDD:278689	50/128 (39%)
		HA2	842..926	CDD:214852	30/90 (33%)
		OB_NTP_bind	974..1078	CDD:285018	38/216 (18%)
Dhx34	NP_001272860.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		HrpA	153..>688	CDD:224557	199/603 (33%)
		DEAH box	281..284		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	726..764		5/37 (14%)
		OB_NTP_bind	800..910	CDD:369483	26/114 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1091..1114
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820