DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mle and Dhx35

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_001359442.1	Gene:	Dhx35 / 71715	MGIID:	1918965	Length:	703	Species:	Mus musculus

Alignment Length:	738	Identity:	209/738 - (28%)
Similarity:	325/738 - (44%)	Gaps:	139/738 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   363 SLRDRRQNDNE-------YRQFL-----EFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTT 415
            |:.:.||:..|       |..:.     :.|:|||:..:|:.||..:.:...|:|.|.|||||:|
Mouse    21 SISEERQSVTENSGTTIIYNPYAALSIEQQRQKLPVFKLRNHILYLVENYQTVVIVGETGCGKST 85

  Fly   416 QIAQYILD-DYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPY 479
            ||.||:.: .:...|:    .:.||||||::|::||.|||.||...||..|||.:||:.......
Mouse    86 QIPQYLAEAGWTAEGR----VVGVTQPRRVAAVTVAGRVADERGAVLGHEVGYCIRFDDCTDPLA 146

  Fly   480 GAILFCTVGVLLRKL--EAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATI 542
            ..|.|.|.|:|:|::  :..|...|.|::||.|||.:.:|..:.:|:.:.....||.:|:.|||:
Mouse   147 TRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATL 211

  Fly   543 DTTKFSKYFG----------ICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEE 597
            |..||..:|.          ....|.|.||.|||..|:|:..:.
Mouse   212 DAEKFRDFFNQNETSDPARDTSVTLTVEGRTFPVDIFYLQSPVP--------------------- 255

  Fly   598 QLLSEDKDEAEINYNKVCED---KYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVF 659
                        :|.|...|   |..|         :|.|                   |.||.|
Mouse   256 ------------DYIKATVDTVVKIHQ---------TEGD-------------------GDILAF 280

  Fly   660 LPGW-------NLIFALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILST 717
            |.|.       :::....:.|..|   |.....::||.::.:|..||.||||.|...|.|:|::|
Mouse   281 LTGQEEVETVVSMLIEQARALART---GMKKHLRVLPMYAGLPSFEQMKVFERVSHSVRKVIVAT 342

  Fly   718 NIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCS 782
            |:|||||||..||:|||....:::.:.....:.....|..|:.:..||.||.||.|.|.|:.|.:
Mouse   343 NVAETSITISGIVYVIDCGFMKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRNRSGKCYRLYT 407

  Fly   783 RARFQALEDNLTPEMFRTPLHEMALTIKLLRLGSI--HHFLSKALEPPPVDAVIEAEVLLREMRC 845
            ...|..|..:..|||.|:.|..:.|.:|.|.:.::  .||:|    |||..::::|..||..:..
Mouse   408 EEAFDQLPQSTVPEMQRSNLAPVILQLKALGIDNVLRFHFMS----PPPAQSMVQALELLYALGG 468

  Fly   846 LDANDELT-PLGRLLARLPIEPRLGKMMVLGAVFGCA-DLMAIMASYSSTFSEVFSLDIGQRRLA 908
            ||.:..|| |||..:|..|:.|...||::....|||: ::::|.|...  ...||.....|:..|
Mouse   469 LDKDCRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEVLSIAAMMQ--IQNVFVFPSNQKSQA 531

  Fly   909 NHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQ 973
            .........:..||:.|:...:.:.:..:..:..:..|.::|||..:.     ..:.||..||.:
Mouse   532 TRVHRKFAVEEGDHLTMLNVYEAFIKHNKSSQWCQEHFLNYKGLVRAA-----TVRDQLKKLLVK 591

  Fly   974 AGFPEECMISHEVDERIDGDDPVLDVSLALLCL--GLYPNICVHKEKRKVLTTESKAAL-LHKTS 1035
            ...|:   :|.|.|     .|||      |.|:  |.:.|...........|......| :|..|
Mouse   592 FQVPK---VSSEGD-----PDPV------LRCIVSGFFANAARFHSSGAYRTIRDDHELHIHPAS 642

  Fly  1036 VNCSNLAVTFPYPFFVFGEKIRT 1058
            |    |....|..:.::.|.|:|
Mouse   643 V----LYAEKPPRWVIYNEVIQT 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634
		DEXDc	393..569	CDD:214692	70/188 (37%)
		DEXDc	402..542	CDD:238005	56/142 (39%)
		ATP-synt_B	<584..644	CDD:304375	7/62 (11%)
		Helicase_C	643..772	CDD:278689	43/135 (32%)
		HA2	842..926	CDD:214852	23/85 (27%)
		OB_NTP_bind	974..1078	CDD:285018	21/88 (24%)
Dhx35	NP_001359442.1	HrpA	21..682	CDD:224557	209/738 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810