DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mle and Dhx16

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	XP_006524936.1	Gene:	Dhx16 / 69192	MGIID:	1916442	Length:	1049	Species:	Mus musculus

Alignment Length:	1027	Identity:	257/1027 - (25%)
Similarity:	425/1027 - (41%)	Gaps:	272/1027 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 TGLEGAGMAGGSGQQKR----------VFDGQSGPQDLGEA-------------YRPLNHDGGDG 133
            :|.|..|..|.|.|:||          ..|.:...:::.|:             .:|.:.|..:.
Mouse   105 SGEEAVGSNGSSLQKKRKRRKHLRKKHQEDEEDEEEEVSESGKRKAGGSKSPTEEKPASEDEWER 169

  Fly   134 GNRYSVIDRIQEQRDMNEAEAFDVNAAIHGNWTIENAKERLNIYKQTNNI--RDDYKYTPVGPEH 196
            ..|    :|:|   |:.|.:||           .|..::|..  .:|.|:  |.|.|......:.
Mouse   170 TER----ERLQ---DLEERDAF-----------AERVRQRDK--DRTRNVLERSDKKAYEEAQKR 214

  Fly   197 ARSFLAELSIYVPALNRTVTARESGSNKKSASKSCALSLVRQLFHLNVIEPFSGTLKKKKDEQLK 261
            .:....:....||.|           .|||..:                     .|.|::.|:|:
Mouse   215 LKMAEEDRKAMVPEL-----------RKKSRRE---------------------YLAKREREKLE 247

  Fly   262 PYPVKLSPNLINKIDEVIKG-LDLPVVNPRNIKIELDGPPIPLIVNLSRIDSSQQDGEKR----- 320
            ....:|:.      :||:.| ::|.....|.:|.:      ..:.:|:|...:..:.||.
Mouse   248 DLEAELAD------EEVLFGDVELSRHERRELKYK------RRVRDLAREYRAAGEQEKLEATNR 300

  Fly   321 ------------------QESSVIPWAPPQANWNTWHACNIDEGELATTSI-------------- 353
                              :|.|..| ...|..|        :|.:|...|:
Mouse   301 YHMPKETRGQPARTVDIVEEESGAP-GEEQRRW--------EEAQLGAASLKFGARDAAAQEAKY 356

  Fly   354 -----DDLSMDYERSLRDRRQNDNE-----------YRQFLE-FREKLPIAAMRSEILTAINDNP 401
                 :|.::::.|:.  :.|.|.|           .::.:: .|..||:...|.|:|.||.::.
Mouse   357 QLVLEEDETIEFVRAA--QLQGDEEPSGPPLSAQAQQKESIQAVRRSLPVFPFREELLAAIANHQ 419

  Fly   402 VVIIRGNTGCGKTTQIAQYILDDYICSGQGGYA----NIYVTQPRRISAISVAERVARERCEQLG 462
            |:||.|.||.||||||.||:.::       ||.    .|..|||||::|:|||.|||||...:||
Mouse   420 VLIIEGETGSGKTTQIPQYLFEE-------GYTKKGMKIACTQPRRVAAMSVAARVAREMGVKLG 477

  Fly   463 DTVGYSVRFESVFPRPYGAILFCTVGVLLRKL--EAGLRGVSHIIVDEIHERDVNSDFLLVILRD 525
            :.||||:|||.. ......:.:.|.|:|||:.  |..|...|.::|||.|||.:::|.|..:::|
Mouse   478 NEVGYSIRFEDC-TSERTVLRYMTDGMLLREFLSEPDLASYSVVMVDEAHERTLHTDILFGLIKD 541

  Fly   526 MVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKR 590
            :....|:|.|::.|||:||.:||.:|...||..:|||.|||..|:.:        .|.|:
Mouse   542 VARFRPELKVLVASATLDTARFSAFFDDAPVFRIPGRRFPVDIFYTK--------APEAD----- 593

  Fly   591 KEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGA 655
                                |.:.|                       ::..|.:|:...  ||.
Mouse   594 --------------------YLEAC-----------------------VVSVLQIHVTQP--PGD 613

  Fly   656 ILVFLPGW-----NLIFALMKFLQN--TNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKI 713
            |||||.|.     ..|.|..:.||:  ..:.....:..:||.::.:|.|.|.::|:|.|.|..|:
Mouse   614 ILVFLTGQVSAVVEEIEAACEMLQDRCRRLGSKIRELLVLPIYANLPSDMQARIFQPTPPGARKV 678

  Fly   714 ILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCF 778
            :::|||||||:||:.|::|:|....:.|.:.....:.|......||.:..||.||||||..|.||
Mouse   679 VVATNIAETSLTIEGIIYVLDPGFCKQKSYNPRTGMESLTVTPCSKASANQRAGRAGRVAAGKCF 743

  Fly   779 TLCSRARFQ-ALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVDAVIEAEVLLRE 842
            .|.:...:| .||:...||:.||.|..:.|.:|.|.:..:.||  ..|:|||.:.::.|...|..
Mouse   744 RLYTAWAYQHELEETTVPEIQRTSLGNVVLLLKSLGIHDLMHF--DFLDPPPYETLLLALEQLYA 806

  Fly   843 MRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEVFSLDIGQRRL 907
            :..|:...|||..||.:|.||::|.|.||::....:.|::.:..:|:..|..:.:|.....:...
Mouse   807 LGALNHLGELTTSGRKMAELPVDPMLSKMILASEKYSCSEEILTVAAMLSVNNSIFYRPKDKVVH 871

  Fly   908 ANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQ 972
            |::.:........||:.::.....|..     ....:::|....:|..:|....|.::||..||:
Mouse   872 ADNARVNFFLPGGDHLVLLNVYTQWAE-----SGYSSQWCYENFVQFRSMRRARDVREQLEGLLE 931

  Fly   973 QAGFPEECMISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKEKRKVLTT 1024
            :                       ::|.|. .|.|.|..:      ||.:|:
Mouse   932 R-----------------------VEVGLT-SCQGDYVRV------RKAITS 953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634	12/71 (17%)
		DEXDc	393..569	CDD:214692	79/181 (44%)
		DEXDc	402..542	CDD:238005	62/145 (43%)
		ATP-synt_B	<584..644	CDD:304375	3/59 (5%)
		Helicase_C	643..772	CDD:278689	46/135 (34%)
		HA2	842..926	CDD:214852	20/83 (24%)
		OB_NTP_bind	974..1078	CDD:285018	8/51 (16%)
Dhx16	XP_006524936.1	PTZ00121	<147..>410	CDD:173412	54/337 (16%)
Dhx16	XP_006524936.1	HrpA	377..1036	CDD:224557	199/680 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810