Protein Alignment mle and Dhx34

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: NP_001258381.1
• Gene: Dhx34 / 684903
• RGDID: 1584452
• Length: 1143
• Species: Rattus norvegicus
• Alignment Length: 880
• Identity: 254/880 - (28%)
• Similarity: 387/880 - (43%)
• Gaps: 217/880 - (24%)

  Fly   372 NEYRQ----FLEFREK---------------LPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQI 417
            :|:|:    :|:|::|               ||||...:.||..:.::.||::.|:|||||:||:
  Rat   132 SEFRRALLHYLDFQQKQAFGRLAKLQRERAALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQV 196

  Fly   418 AQYILDDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGA- 481
            .||:|       ..|::::..||||||:.||:|:||..|...|.|..|||.:||||.  |....
  Rat   197 PQYLL-------AAGFSHVACTQPRRIACISLAKRVGFESLSQYGSQVGYQIRFEST--RSAATK 252

  Fly   482 ILFCTVGVLLRKL--EAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDT 544
            |:|.|||:|||::  |..|.....:||||:|||.:::||||.:|:.::...|||.||||||||:.
  Rat   253 IVFLTVGLLLRQIQCEPRLPQYQVLIVDEVHERHLHNDFLLGVLQRLLPQRPDLKVILMSATINI 317

  Fly   545 TKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEI 609
            :.||.||...||::||||.||:...:...         .||....:.|..|....|
  Rat   318 SLFSSYFSHAPVVQVPGRLFPITVVYQPQ---------EAEQSASKSEKLDPRPFL--------- 364

  Fly   610 NYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQ 674
            ...:..::||..:.|                             |.:||||.|...|..::...|
  Rat   365 RVLEAIDNKYPPEER-----------------------------GDLLVFLSGMAEISTVLDAAQ 400

  Fly   675 NTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKAR 739
            .....  |.::.:||.||.:...:|.|||:..|.||.|.||||||||||:|||.|.||:|..|.:
  Rat   401 AYATL--TQRWVVLPLHSALSVADQDKVFDVAPAGVRKCILSTNIAETSVTIDGIRFVVDSGKVK 463

  Fly   740 MKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHE 804
            ...:.....|......|.|:.:.|||||||||..||.|:.|.:.:.:.|......||:.|..|..
  Rat   464 EMSYDPQAKLQRLQEFWISQASAEQRKGRAGRTGPGVCYRLYAESDYDAFAPYPVPEIRRVALDA 528

  Fly   805 MALTIKLLRLGSIHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLG 869
            :.|.:|.:.:|....|  ..:||||..:|..|.:.|::...||:::.|||:|.|||:||::..:|
  Rat   529 LVLQMKSMSVGDPRTF--PFIEPPPAASVETAILYLQDQGALDSSEALTPIGSLLAQLPVDVVIG 591

  Fly   870 KMMVLGAVFGCAD-LMAIMASYS----STFSEVFSLD--IGQRRLANHQKALSGTKCSDHVAMIV 927
            |||:||::|..|: ::.|.|:.|    .|.|...:||  ..:|.|.:.|        .|...:..
  Rat   592 KMMILGSMFSLAEPVLTIAAALSVQSPFTRSAQSNLDCATARRPLESDQ--------GDPFTLFN 648

  Fly   928 ASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFPEECMI---------- 982
            ....|.:.|........::|..:|::...:..:.:.::|..:||:..|......:
  Rat   649 VFNAWVQVKSERSGNSRKWCRRRGVEEHRLYEMANLRRQFKELLEDHGLLRGAQVVAPRDSYSRL 713

  Fly   983 --------------------------------------SHE--VDERIDGDDPVLDV-------- 999
                                                  .||  ..:|.|..| :.||
  Rat   714 QQRRERQTLHQLKRQHEEGGGRRRKVLRLQEDGCSSDEDHEGSASQRADSVD-IQDVKFKLRHNL 777

  Fly  1000 ----------------SLALLCL----GLYPNICV-------HKEKRKVLTTESK-AALLHKTSV 1036
                            .||||.|    ||||.:.|       .|:..::..|::| ..:||.|.|
  Rat   778 EQLQAAASSAQDLTRDQLALLKLVLGRGLYPQLAVPDAFNSGRKDSDQIFHTQAKQGTVLHPTCV 842

  Fly  1037 NCSNLAVTFPYPFFVFGEKIRTR--------AVSCKQ--LSMVS----------------PLQVI 1075
            ..::     |......|.:...|        .:|||.  |:.||                .||.:
  Rat   843 FANS-----PEVLHTQGPEASGREGSQDGKDQMSCKHQLLAFVSLLETNKPYLVNCVRIPALQSL 902

  Fly  1076 LFGSRKIDLAAN-NIVRVDNWLNFDI-EPELAAKI 1108
            |..||.||...: :.:..|.||...: :.|.|.::
  Rat   903 LLFSRSIDTNGDCSRLVADGWLELQLADSESAVRL 937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684
		DEXHc_DHX9	326..559	CDD:350730	86/208 (41%)
		HrpA	378..>889	CDD:441249	189/529 (36%)
		OB_NTP_bind	1002..1079	CDD:400182	28/114 (25%)
Dhx34	NP_001258381.1	HrpA	161..>627	CDD:441249	190/525 (36%)
		OB_NTP_bind	798..909	CDD:400182	28/115 (24%)