Protein Alignment mle and Dqx1

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: XP_038964267.1
• Gene: Dqx1 / 680434
• RGDID: 1591766
• Length: 780
• Species: Rattus norvegicus
• Alignment Length: 897
• Identity: 208/897 - (23%)
• Similarity: 342/897 - (38%)
• Gaps: 203/897 - (22%)

  Fly   345 EGELATTSIDDLSMDYERSLRDRRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNP--VVIIRG 407
            |.|||....|.|..            .:.|.:.||.|..|||.|.|...|..:..:|  ||::.|
  Rat    15 ESELAVNPFDGLPF------------SSCYYELLEQRRALPIWAARFLFLEHLESSPTGVVLVSG 67

  Fly   408 NTGCGKTTQIAQYILDDYICSG-QGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRF 471
            ..|.||:|||.|:..:..:..| |.|  .:.||||..::|:|:|.|||.|....||..:|||:..
  Rat    68 EPGSGKSTQIPQWCAEFALARGFQTG--QVTVTQPYPLAAMSLASRVADEMDLTLGHEIGYSIPQ 130

  Fly   472 ESVFPRPYGAILFCTVGVLLRKLEAGLRGV---SHIIVDEIHERDVNSDFLLVILRD-MVDTYP- 531
            |.. ..|...:.||...:.|::: |..||.   |.:::||..||.|.||.|..:||| .:...|
  Rat   131 EDC-TGPNTMLRFCWDRLFLQEV-ASTRGPGAWSVLVLDEAQERSVASDLLQGLLRDTRLRNLPG 193

  Fly   532 DLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDE 596
            |..|::::.:....||..::|..|.:.||                              :|..:.
  Rat   194 DPRVVIVTDSALEPKFQAFWGNSPTVHVP------------------------------REPGEN 228

  Fly   597 EQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLP 661
            ..|..:|...|:: ....|                         :|:|...:.:..||.:||:||
  Rat   229 PTLTYKDTVPADL-VEAAC-------------------------QAVLELCQREEAPGDVLVYLP 267

  Fly   662 GWNLIF----ALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAET 722
            ....|.    :|.:.:....:.|...  ::||.|....:..| .|:|.....|.||:::..:|:.
  Rat   268 SEEEISLCCESLSREMGMLAVPGPLP--RVLPLHPGCGQAIQ-TVYEDTDVSVRKIVVTHWLADF 329

  Fly   723 SITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQ 787
            |.::..|..|||.......::.......|......||...|.|..||....||.|..|.|::...
  Rat   330 SFSLPFIQHVIDSGLELRSVYNPRIRAESQVLRRISKCQAEARLLRARGFPPGTCLRLYSKSTLD 394

  Fly   788 ALEDNLT-PEMFRTPLHEMALTIKLLRL---GSIHHFLSKALEPPPVDAVIEAEVLLREMRCLDA 848
            .....|. |::....|..:.|.:|..::   |..|.     |:.|..:|:::|...|..:..||.
  Rat   395 LEAPPLPHPKVCEENLSSLVLLLKRKQIAEPGECHF-----LDRPAPEALMQALEDLDYLAALDD 454

  Fly   849 NDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEVFS---LDIGQRRLANH 910
            :.:|:.||.:|:..|:.|.|.|.::....|.|.|.|..:|: ..|.:..|:   |..|:..|...
  Rat   455 DGDLSDLGIILSEFPLPPELAKALLASCEFNCVDEMLTLAA-MLTAAPGFTRPPLCAGEAALRRG 518

  Fly   911 QKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDA-------KQQLL 968
            .:...|    ||.::|   |::....|.|  .:..:|..:||.       |:|       :.:||
  Rat   519 LEHADG----DHSSLI---QVYEAFVQSG--ADETWCQARGLS-------WEALCQARKLRAELL 567

  Fly   969 DLLQQAGFPEEC-MISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKEKRKVLTTES------ 1026
            :|:|:...|... ....|.:.|        |:..|||. |.:....:.:.....|.::|
  Rat   568 ELMQRIELPLSLPAFGSEQNRR--------DLQKALLS-GYFLKAMMRRGLMSKLPSDSLSTSGW 623

  Fly  1027 -KAALLHKTSVNCSNLAVTFPYPFFVFGEKIRTRAVSCKQLSMVSPLQVILFG--SRKIDLAANN 1088
             :.|.|...|...:.:..|....||:|          |  .|::||...:.|.  :|..|...|.
  Rat   624 PQTAPLAPYSATQAGITATPALAFFIF----------C--ASLLSPPMYLCFNEVARDTDGTGNY 676

  Fly  1089 IV----------------------RVDNWL---NFDIEPELAAKIGALKPALEDLITVACDNPSD 1128
            ::                      :...|:   .|.|..:            ..|.||:...|..
  Rat   677 LLLTHKHVAQLSPYCVYRNRRTPAQPPTWVLYHRFSISKD------------NCLCTVSEIQPEM 729

  Fly  1129 ILRLEEPYAQLVKVVKDLCVKSAGDFGLQRESGILPHQS-------RQFSDG 1173
            ::.|..||     .:.:|....:.|...|...|..|..:       :::.||
  Rat   730 LVELAPPY-----FLSNLPPSESRDLLNQLREGTEPSAAVTETASPQEYGDG 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684
		DEXHc_DHX9	326..559	CDD:350730	73/221 (33%)
		HrpA	378..>889	CDD:441249	137/526 (26%)
		OB_NTP_bind	1002..1079	CDD:400182	18/85 (21%)
Dqx1	XP_038964267.1	HrpA	41..>498	CDD:441249	135/525 (26%)
		DEAD-like_helicase_N	42..221	CDD:475120	63/182 (35%)
		OB_NTP_bind	662..737	CDD:400182	12/86 (14%)