DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and Dqx1

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	XP_038964267.1	Gene:	Dqx1 / 680434	RGDID:	1591766	Length:	780	Species:	Rattus norvegicus

Alignment Length:	897	Identity:	208/897 - (23%)
Similarity:	342/897 - (38%)	Gaps:	203/897 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   345 EGELATTSIDDLSMDYERSLRDRRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNP--VVIIRG 407
            |.|||....|.|..            .:.|.:.||.|..|||.|.|...|..:..:|  ||::.|
  Rat    15 ESELAVNPFDGLPF------------SSCYYELLEQRRALPIWAARFLFLEHLESSPTGVVLVSG 67

  Fly   408 NTGCGKTTQIAQYILDDYICSG-QGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRF 471
            ..|.||:|||.|:..:..:..| |.|  .:.||||..::|:|:|.|||.|....||..:|||:..
  Rat    68 EPGSGKSTQIPQWCAEFALARGFQTG--QVTVTQPYPLAAMSLASRVADEMDLTLGHEIGYSIPQ 130

  Fly   472 ESVFPRPYGAILFCTVGVLLRKLEAGLRGV---SHIIVDEIHERDVNSDFLLVILRD-MVDTYP- 531
            |.. ..|...:.||...:.|::: |..||.   |.:::||..||.|.||.|..:||| .:...|
  Rat   131 EDC-TGPNTMLRFCWDRLFLQEV-ASTRGPGAWSVLVLDEAQERSVASDLLQGLLRDTRLRNLPG 193

  Fly   532 DLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDE 596
            |..|::::.:....||..::|..|.:.||                              :|..:.
  Rat   194 DPRVVIVTDSALEPKFQAFWGNSPTVHVP------------------------------REPGEN 228

  Fly   597 EQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLP 661
            ..|..:|...|:: ....|                         :|:|...:.:..||.:||:||
  Rat   229 PTLTYKDTVPADL-VEAAC-------------------------QAVLELCQREEAPGDVLVYLP 267

  Fly   662 GWNLIF----ALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAET 722
            ....|.    :|.:.:....:.|...  ::||.|....:..| .|:|.....|.||:::..:|:.
  Rat   268 SEEEISLCCESLSREMGMLAVPGPLP--RVLPLHPGCGQAIQ-TVYEDTDVSVRKIVVTHWLADF 329

  Fly   723 SITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQ 787
            |.::..|..|||.......::.......|......||...|.|..||....||.|..|.|::...
  Rat   330 SFSLPFIQHVIDSGLELRSVYNPRIRAESQVLRRISKCQAEARLLRARGFPPGTCLRLYSKSTLD 394

  Fly   788 ALEDNLT-PEMFRTPLHEMALTIKLLRL---GSIHHFLSKALEPPPVDAVIEAEVLLREMRCLDA 848
            .....|. |::....|..:.|.:|..::   |..|.     |:.|..:|:::|...|..:..||.
  Rat   395 LEAPPLPHPKVCEENLSSLVLLLKRKQIAEPGECHF-----LDRPAPEALMQALEDLDYLAALDD 454

  Fly   849 NDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEVFS---LDIGQRRLANH 910
            :.:|:.||.:|:..|:.|.|.|.::....|.|.|.|..:|: ..|.:..|:   |..|:..|...
  Rat   455 DGDLSDLGIILSEFPLPPELAKALLASCEFNCVDEMLTLAA-MLTAAPGFTRPPLCAGEAALRRG 518

  Fly   911 QKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDA-------KQQLL 968
            .:...|    ||.::|   |::....|.|  .:..:|..:||.       |:|       :.:||
  Rat   519 LEHADG----DHSSLI---QVYEAFVQSG--ADETWCQARGLS-------WEALCQARKLRAELL 567

  Fly   969 DLLQQAGFPEEC-MISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKEKRKVLTTES------ 1026
            :|:|:...|... ....|.:.|        |:..|||. |.:....:.:.....|.::|
  Rat   568 ELMQRIELPLSLPAFGSEQNRR--------DLQKALLS-GYFLKAMMRRGLMSKLPSDSLSTSGW 623

  Fly  1027 -KAALLHKTSVNCSNLAVTFPYPFFVFGEKIRTRAVSCKQLSMVSPLQVILFG--SRKIDLAANN 1088
             :.|.|...|...:.:..|....||:|          |  .|::||...:.|.  :|..|...|.
  Rat   624 PQTAPLAPYSATQAGITATPALAFFIF----------C--ASLLSPPMYLCFNEVARDTDGTGNY 676

  Fly  1089 IV----------------------RVDNWL---NFDIEPELAAKIGALKPALEDLITVACDNPSD 1128
            ::                      :...|:   .|.|..:            ..|.||:...|..
  Rat   677 LLLTHKHVAQLSPYCVYRNRRTPAQPPTWVLYHRFSISKD------------NCLCTVSEIQPEM 729

  Fly  1129 ILRLEEPYAQLVKVVKDLCVKSAGDFGLQRESGILPHQS-------RQFSDG 1173
            ::.|..||     .:.:|....:.|...|...|..|..:       :::.||
  Rat   730 LVELAPPY-----FLSNLPPSESRDLLNQLREGTEPSAAVTETASPQEYGDG 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634
		DEXDc	393..569	CDD:214692	60/183 (33%)
		DEXDc	402..542	CDD:238005	52/145 (36%)
		ATP-synt_B	<584..644	CDD:304375	6/59 (10%)
		Helicase_C	643..772	CDD:278689	32/132 (24%)
		HA2	842..926	CDD:214852	23/86 (27%)
		OB_NTP_bind	974..1078	CDD:285018	21/111 (19%)
Dqx1	XP_038964267.1	HrpA	15..>601	CDD:224557	174/691 (25%)
Dqx1	XP_038964267.1	OB_NTP_bind	662..737	CDD:400182	12/86 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900