DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and Dhx40

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_080467.3	Gene:	Dhx40 / 67487	MGIID:	1914737	Length:	779	Species:	Mus musculus

Alignment Length:	869	Identity:	228/869 - (26%)
Similarity:	371/869 - (42%)	Gaps:	174/869 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   367 RRQNDNEYRQFLEFREK-------------------------LPIAAMRSEILTAINDNPVVIIR 406
            |||.:.|  :.:|.:|:                         .||...|.:::.|:.||..:|:.
Mouse    13 RRQEEGE--RPIELQEERPSAVRIADREEKGCTSQEGGTTPTFPIQKQRKKLIQAVRDNSFLIVT 75

  Fly   407 GNTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRF 471
            ||||.|||||:.:|:.:    :|...:..|.|||||:::|||||:|||.|....||..|||.|||
Mouse    76 GNTGSGKTTQLPKYLYE----AGFSQHGMIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRF 136

  Fly   472 ESVFPRPYGAILFCTVGVLLRKL--EAGLRGVSHIIVDEIHERDVNSDFLLVILRDMV-DTYPD- 532
            :....:. .||.:.|.|.||:.:  :..|...|.||:||.|||.:.:|.|..:|:.:. |..|:
Mouse   137 DDCSSKE-TAIKYMTDGCLLKHILGDPNLSKFSVIILDEAHERTLTTDILFGLLKKLFQDKSPNR 200

  Fly   533 ---LHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVE 594
               |.|::||||::..|.|.:||.||:.::|||.:||::.|. ::|...|
Mouse   201 KEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFC-NLIGPRD--------------- 249

  Fly   595 DEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVF 659
                                                .|:....:.:..:.|.|....:.|.||||
Mouse   250 ------------------------------------RENTAYIQAIVKVTMDIHLNEMAGDILVF 278

  Fly   660 LPG-------WNLIFALMKF------LQNTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVT 711
            |.|       ..|:|.:.:.      :|:|.:.|    ..||||:..:..|:||::|.|.|.|:.
Mouse   279 LTGQFEIEKSCELLFQMAESVDYDYDVQDTTLDG----LLILPCYGSMTTDQQRRIFLPPPPGIR 339

  Fly   712 KIILSTNIAETSITIDDIVFVIDICKARMKLFTSHN---NLTSYATVWASKTNLEQRKGRAGRVR 773
            |.::||||:.||:|||.|.:|:|....:.   .:||   .|.....|..||:...||.|||||..
Mouse   340 KCVISTNISATSLTIDGIRYVVDGGFVKQ---LNHNPRLGLDILEVVPISKSEALQRSGRAGRTA 401

  Fly   774 PGFCFTLCSRARF-QALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVDAVIEAE 837
            .|.||.:.|:..: |.:.|::.||:.||.|..:.||:|.|.:..:..|  ..|:||....::||.
Mouse   402 SGKCFRIYSKEFWSQCMPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRF--PYLDPPNERLILEAL 464

  Fly   838 VLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLM---AIMASYSSTFSEVFS 899
            ..|.:...:|.:..:|.||..:...|:.|.|...::..|...|.||:   |.|.|..:.|.....
Mouse   465 KQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIRAASLDCEDLLLPIAAMLSVENVFIRPVD 529

  Fly   900 LDIGQRRLANHQK-ALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDA 963
            .:..:.....|:: |......:|...:.|..:..:.........:..:..|:.| .|...|....
Mouse   530 PEYQKEAEQRHRELAAKAGGFNDFATLAVIFEQCKSSGAPASWCQKHWIHWRCL-FSAFRVEAQL 593

  Fly   964 KQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKEKRKVLTTESKA 1028
            ::.:..|.||:.||.|..           :.|..:|....||.|.:.|:......|...|.:.:.
Mouse   594 RELIRKLKQQSDFPRETF-----------EGPKHEVLRRCLCAGYFKNVARRSVGRTFCTMDGRG 647

  Fly  1029 ALLHKTSVNCSNLAVTFPYPFFVFGEKIRTRAVSCKQLSMVSPLQVILFGSRKIDLAANNIVRVD 1093
            :.:|....:..:...| ...:.:|.|.:.|..|..:   :|.|::.
Mouse   648 SPVHIHPSSALHEQET-KLEWIIFHEVLVTTKVYAR---IVCPIRY------------------- 689

  Fly  1094 NWLNFDIEPELAAKIGALKPALEDLITVACDNPSDILRLEEPYAQLVKVVKDLCVKSAGDFGLQR 1158
            .|:. |:.|:| .::.|     .||.:||.....:..|.:....:.||.:||         |:.:
Mouse   690 EWVR-DLLPKL-HELNA-----HDLSSVARREMREDARRKWTNKENVKQLKD---------GISK 738

  Fly  1159 ESGILPHQSRQFSDGGGPPKRGRF 1182
            |  :|....|:..|......|.||
Mouse   739 E--VLKKMQRRNDDKSISDARARF 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634
		DEXDc	393..569	CDD:214692	75/182 (41%)
		DEXDc	402..542	CDD:238005	60/146 (41%)
		ATP-synt_B	<584..644	CDD:304375	1/59 (2%)
		Helicase_C	643..772	CDD:278689	50/144 (35%)
		HA2	842..926	CDD:214852	18/87 (21%)
		OB_NTP_bind	974..1078	CDD:285018	19/103 (18%)
Dhx40	NP_080467.3	OB_NTP_bind	591..699	CDD:285018	25/142 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		6/41 (15%)
		DEXDc	48..236	CDD:214692	76/192 (40%)
		DEXDc	78..213	CDD:238005	57/139 (41%)
		DEAH box	173..176		2/2 (100%)
		HELICc	312..399	CDD:197757	36/93 (39%)
		HA2	469..557	CDD:214852	18/87 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810