DRSC/TRiP Functional Genomics Resources

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Protein Alignment mle and YTHDC2

DIOPT Version :9

Sequence 1:NP_476641.1 Gene:mle / 35523 FlyBaseID:FBgn0002774 Length:1293 Species:Drosophila melanogaster
Sequence 2:XP_011541883.1 Gene:YTHDC2 / 64848 HGNCID:24721 Length:1439 Species:Homo sapiens


Alignment Length:1323 Identity:381/1323 - (28%)
Similarity:551/1323 - (41%) Gaps:399/1323 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 PADAGASGGGPRTGLEGAGMAGGSGQQKRVFDGQSGPQDLGEAYRPLNHDGGDGGNRYSVIDRIQ 144
            ||..|..||||    ...| .||.|:.|       |.:|:                      ||.
Human    12 PAPGGGGGGGP----SPCG-PGGGGRAK-------GLKDI----------------------RID 42

  Fly   145 EQRDMNEAEAFDVNAAIHGNWTIENAKERLNIYKQTNNIRDDYKYTPVGPEHARSFLAELSIYVP 209
            |          :|..|::      .|.||.....|.     :.::........|:|:..||   .
Human    43 E----------EVKIAVN------IALERFRYGDQR-----EMEFPSSLTSTERAFIHRLS---Q 83

  Fly   210 ALNRTVTARESGSNKKSASKSCALSLVRQLFHLNVIEPFSGTLKKKKDEQLKPYPVKLSPNLINK 274
            :|.....::..|:|:                :|.|         ||||.....:.: ::.||.:.
Human    84 SLGLVSKSKGKGANR----------------YLTV---------KKKDGSETAHAM-MTCNLTHN 122

  Fly   275 IDEVIKGL--DLPVVNPRNIKIELDGPPIPLIVNLSRIDSSQQDGEKRQESSV-------IPWAP 330
            ....::.|  ..||.|....:         |:....|.:....:.|.|:.|..       ||..|
Human   123 TKHAVRSLIQRFPVTNKERTE---------LLPKTERGNVFAVEAENREMSKTSGRLNNGIPQIP 178

  Fly   331 PQANWNTWHACNIDEGELATTSIDDLSMDYERSLRDRRQNDNEYRQFLEFREKLPIAAMRSEILT 395
                        :..||                           .:|..||:.||:...:.||:.
Human   179 ------------VKRGE---------------------------SEFDSFRQSLPVFEKQEEIVK 204

  Fly   396 AINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQ 460
            .|.:|.||:|.|.||.||||||.|::|||  |...|....|:.|||||::||:||||||.||.|:
Human   205 IIKENKVVLIVGETGSGKTTQIPQFLLDD--CFKNGIPCRIFCTQPRRLAAIAVAERVAAERRER 267

  Fly   461 LGDTVGYSVRFES-VFPRPYGAILFCTVGVLLRKLEAG---LRGVSHIIVDEIHERDVNSDFLLV 521
            :|.|:||.:|.|| |.|:.  .:.|||.|||||.|.||   |..|:|:||||:||||..|||||.
Human   268 IGQTIGYQIRLESRVSPKT--LLTFCTNGVLLRTLMAGDSTLSTVTHVIVDEVHERDRFSDFLLT 330

  Fly   522 ILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMT-------- 578
            .|||::..:|.|.:||.||.:|...|.:|||.|||:.:.||.|.|::.|||||::.|        
Human   331 KLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKEML 395

  Fly   579 -------------------------DFVPSAESRRKRKEVEDEEQLLSEDKD-------EAEIN- 610
                                     .|.|.::.:|....|.||..||.:..|       |.::| 
Human   396 KYKKEKQQEEKQQTTLTEWYSAQENSFKPESQRQRTVLNVTDEYDLLDDGGDAVFSQLTEKDVNC 460

  Fly   611 ----------------------------------YNKVCEDKYSQKTRNAMAM------------ 629
                                              .|...:.::|:.:..|:.:            
Human   461 LEPWLIKEMDACLSDIWLHKDIDAFAQVFHLILTENVSVDYRHSETSATALMVAAGRGFASQVEQ 525

  Fly   630 ---------------------------------------------LSE--------SDVSF---E 638
                                                         |.|        ||:|.   |
Human   526 LISMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSATLEFGNLDESSLVQTNGSDLSAEDRE 590

  Fly   639 LLEA-------------LLMHIKSKNI-----PGAILVFLPGWNLIFALM-KFLQNTNIFGD-TS 683
            ||:|             |:||: ..||     .||:|:||||::.|..|. :.|.:...|.| |.
Human   591 LLKAYHHSFDDEKVDLDLIMHL-LYNICHSCDAGAVLIFLPGYDEIVGLRDRILFDDKRFADSTH 654

  Fly   684 QYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNN 748
            :||:...||.:...:|:||.:..|.||.||||||||||||||::|:|||||..|.:.|.|.:.|.
Human   655 RYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNF 719

  Fly   749 LTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLLR 813
            :|....||.||.:..||||||||.|||.||.|.||.|||.:.:..|||:.|.||.|:.|..|||.
Human   720 VTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQNMLEFQTPELLRMPLQELCLHTKLLA 784

  Fly   814 LGS--IHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGA 876
            ..:  |..||.||.||||...|..|..:|:.:..:|..::||.||..||.||:||.||||::...
Human   785 PVNCPIADFLMKAPEPPPALIVRNAVQMLKTIDAMDTWEDLTELGYHLADLPVEPHLGKMVLCAV 849

  Fly   877 VFGCAD---LMAIMASYSSTFSEVFSLDIGQRRLAN-HQKALSGTKCSDHVAMIVASQMWRREKQ 937
            |..|.|   .:|...:|...|  |......|:|.|. .:|..:....|||:|::.|.|.|  :|.
Human   850 VLKCLDPILTIACTLAYRDPF--VLPTQASQKRAAMLCRKRFTAGAFSDHMALLRAFQAW--QKA 910

  Fly   938 RGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSL- 1001
            |.:..|..||:...|..:||.:|...:.|||..|:.:||         |..|..||  :.||:. 
Human   911 RSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGF---------VRARGGGD--IRDVNTN 964

  Fly  1002 --------ALLCLGLYPNICVHKEKRKVLTT--ESKAALLHKTSV------------NCSNLAV- 1043
                    |.|..|:|||: ||.::..::.|  :.|....|..||            |....|: 
Human   965 SENWAVVKAALVAGMYPNL-VHVDRENLVLTGPKEKKVRFHPASVLSQPQYKKIPPANGQAAAIK 1028

  Fly  1044 TFPYPFFVFGEKIRT-RAVSCKQLSMVSPLQVILF--------------GSRKIDLAANN----- 1088
            ..|..:.::.|..|. |..:.:..|.|:|:.:::|              .|.::|...|:     
Human  1029 ALPTDWLIYDEMTRAHRIANIRCCSAVTPVTILVFCGPARLASNALQEPSSFRVDGIPNDSSDSE 1093

  Fly  1089 ----------IVRVDNWLNFDIEPELAAKIGALKPALEDLITVACDNPSDILRLEEPYAQL---- 1139
                      .:::|.||:|.:|||.|:.:..|:.....|.......||      :|::|:    
Human  1094 MEDKTTANLAALKLDEWLHFTLEPEAASLLLQLRQKWHSLFLRRMRAPS------KPWSQVDEAT 1152

  Fly  1140 VKVVKDLCVKSAGDFGLQRESGI 1162
            ::.:..:........|||:.|||
Human  1153 IRAIIAVLSTEEQSAGLQQPSGI 1175

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mleNP_476641.1 DSRM 4..68 CDD:214634
DSRM 170..240 CDD:214634 11/69 (16%)
DEXDc 393..569 CDD:214692 95/179 (53%)
DEXDc 402..542 CDD:238005 80/143 (56%)
ATP-synt_B <584..644 CDD:304375 21/182 (12%)
Helicase_C 643..772 CDD:278689 64/135 (47%)
HA2 842..926 CDD:214852 30/87 (34%)
OB_NTP_bind 974..1078 CDD:285018 31/142 (22%)
YTHDC2XP_011541883.1 R3H_DEXH_helicase 46..104 CDD:100077 14/96 (15%)
HrpA 189..>1016 CDD:224557 295/847 (35%)
DEXHc_YTHDC2 193..368 CDD:350745 94/178 (53%)
ANK repeat 505..537 CDD:293786 1/31 (3%)
ANK repeat 539..564 CDD:293786 0/24 (0%)
OB_NTP_bind 971..1066 CDD:369483 23/95 (24%)
YTH 1288..1404 CDD:367840
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1643
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D222681at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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