DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and Dhx38

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_848467.1	Gene:	Dhx38 / 64340	MGIID:	1927617	Length:	1228	Species:	Mus musculus

Alignment Length:	825	Identity:	224/825 - (27%)
Similarity:	376/825 - (45%)	Gaps:	174/825 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   274 KIDEVIKGLDLPVVNPRNIKIELDGPPIPL------IVNLSR-----IDSSQQDGEKRQESSVIP 327
            |:..::..|..|.::.|.:..:...|.||:      :..::|     :...::..|:|
Mouse   405 KVHLMVHNLVPPFLDGRIVFTKQPEPVIPVKDATSDLAIIARKGSQTVRKHREQKERR------- 462

  Fly   328 WAPPQANWNTWHACNIDEGELATTSIDDL-----------------SMDYERS------LRDRRQ 369
                :|....|        |||.|.:.|:                 .:||...      ::::.:
Mouse   463 ----KAQHKHW--------ELAGTKLGDIMGVKKEEEPDKAMTEDGKVDYRTEQKFADHMKEKSE 515

  Fly   370 NDNEY---RQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQG 431
            ..:|:   :..||.|:.|||.|::.|:||.|.||.:||:.|.||.|||||:.||:.:|    |..
Mouse   516 ASSEFAKKKSILEQRQYLPIFAVQQELLTIIRDNSIVIVVGETGSGKTTQLTQYLHED----GYT 576

  Fly   432 GYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRK--L 494
            .|..|..|||||::|:|||:||:.|....||:.|||::|||.. ......|.:.|.|:|||:  .
Mouse   577 DYGMIGCTQPRRVAAMSVAKRVSEEMGGNLGEEVGYAIRFEDC-TSENTLIKYMTDGILLRESLR 640

  Fly   495 EAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEV 559
            ||.|...|.:|:||.|||.:|:|.|..:||::|....||.:|:.|||:|..||:.:||..|:..:
Mouse   641 EADLDHYSAVIMDEAHERSLNTDVLFGLLREVVARRSDLKLIVTSATMDAEKFAAFFGNVPIFHI 705

  Fly   560 PGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTR 624
            |||.|||                                         :|.::|..::.|
Mouse   706 PGRTFPV-----------------------------------------DILFSKTPQEDY----- 724

  Fly   625 NAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGW-------NLIFALMKFLQNTNIFGDT 682
                      |...:.::|.:|:  ...||.||:|:||.       :.|...::.|:|.....
Mouse   725 ----------VEAAVKQSLQVHL--SGAPGDILIFMPGQEDIEVTSDQIVEHLEELENAPALA-- 775

  Fly   683 SQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHN 747
                :||.:||:|.|.|.|:|:..|:||.|.|::|||||||:|:|.|:||||....::|:|....
Mouse   776 ----VLPIYSQLPSDLQAKIFQKAPDGVRKCIVATNIAETSLTVDGIMFVIDSGYCKLKVFNPRI 836

  Fly   748 NLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQ-ALEDNLTPEMFRTPLHEMALTIKL 811
            .:.:......|:.|..||.|||||..||.||.|.:::.:: .|.....||:.||.|..:.|.:|.
Mouse   837 GMDALQIYPISQANANQRSGRAGRTGPGQCFRLYTQSAYKNELLTTTVPEIQRTNLANVVLLLKS 901

  Fly   812 LRLGSI--HHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVL 874
            |.:..:  .||    ::|||.|.::.:...|..:..||....||..|||:...|::|.|.||:::
Mouse   902 LGVQDLLQFHF----MDPPPEDNMLNSMYQLWILGALDNTGGLTSTGRLMVEFPLDPALSKMLIV 962

  Fly   875 GAVFGCADLMAIMASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRG 939
            ....||:..:.::.|..|. ..:|....|:...::..:.......|||:..:.....|     :.
Mouse   963 SCDMGCSSEILLIVSMLSV-PAIFYRPKGREEESDQIREKFAVPESDHLTYLNVYLQW-----KN 1021

  Fly   940 EHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQA-----------GFPEECMIS---HEVDERI 990
            .:....:|:...:....|..:.:.:.||.|::.|.           ....:|:.:   |:. .::
Mouse  1022 NNYSTIWCNDHFIHAKAMRKVREVRAQLKDIMVQQRMSLASCGTDWDIVRKCICAAYFHQA-AKL 1085

  Fly   991 DGDDPVLDVSLALLC----------LGLYPNICVHKEKRKVLTTE 1025
            .|....:::...:.|          :|..|:..|:.|  .|:||:
Mouse  1086 KGIGEYVNIRTGMPCHLHPTSSLFGMGYTPDYIVYHE--LVMTTK 1128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634
		DEXDc	393..569	CDD:214692	81/177 (46%)
		DEXDc	402..542	CDD:238005	63/141 (45%)
		ATP-synt_B	<584..644	CDD:304375	4/59 (7%)
		Helicase_C	643..772	CDD:278689	50/135 (37%)
		HA2	842..926	CDD:214852	21/83 (25%)
		OB_NTP_bind	974..1078	CDD:285018	11/76 (14%)
Dhx38	NP_848467.1	DEXDc	527..714	CDD:214692	89/232 (38%)
		DEXDc	552..688	CDD:238005	63/140 (45%)
		HELICc	759..862	CDD:197757	42/108 (39%)
		HA2	931..1013	CDD:214852	21/82 (26%)
		OB_NTP_bind	<1064..1147	CDD:285018	11/68 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810