DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and dhx8

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	XP_002663993.1	Gene:	dhx8 / 606595	ZFINID:	ZDB-GENE-050809-39	Length:	1210	Species:	Danio rerio

Alignment Length:	1079	Identity:	260/1079 - (24%)
Similarity:	442/1079 - (40%)	Gaps:	234/1079 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LCEVRVEPNTYIGVGNSTNKKDAEKNACRDFVNYLVRVG---KLNTNDVPADAGASGGGPRTGLE 95
            :.|:|.|       |...|..|......|..|..|...|   .|:..||..|.|......|
Zfish   287 ISELRRE-------GRVANVADVVSKGQRVKVKVLSFTGSKTSLSMKDVDQDTGEDLNPNR---- 340

  Fly    96 GAGMAGGSGQQKRVFDGQSGPQDLGEAYRPLNHDGGDGGNRYSVIDRIQEQR--DMNEAEAFDVN 158
             ....||.||::........|.:|...:.|...|           |.::.:|  .:::.|.:::.
Zfish   341 -RRNVGGEGQEESAMRNPDRPTNLNLGHAPEVED-----------DTLERKRLTKISDPEKWEIK 393

  Fly   159 AAIHGNWTIENAKERLNIYKQTNNIRDDYKYTPVGPEHARSFLAELSIYVPALNR---------- 213
            ..|..|..   :||....:.:...|     ...|..|.......||....|...|
Zfish   394 QMIAANVL---SKEEFPDFDEETGI-----LPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMS 450

  Fly   214 --TVTARESGSNKKSASKSCALSLVRQLFHLNVIEPFSGTLKKKKDEQLKPYPVKLSPNLINKID 276
              .:.....||..::|....||:..|:           ...:.:::.::...|:.|:.:.::
Zfish   451 PVKIVKNPDGSLSQAAMMQSALAKERR-----------EVKQAQREAEMDSIPMGLNKHWVD--- 501

  Fly   277 EVIKGLDLPVVNPRNIKIELDGPPIPLIVNLSRIDSSQQDGEKRQESSVIPWAPPQANWNTWHAC 341
                  .||.|:.|.|...:.|                        ..::|...|:...:.:...
Zfish   502 ------PLPDVDGRQIAANMRG------------------------IGMMPNDIPEWKKHAFGGN 536

  Fly   342 NIDEGELATTSIDDLSMDYERSLRDRRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIR 406
            ....|:....||                        ||.||.|||..::.:::.|::||.::|:.
Zfish   537 KASYGKKTQLSI------------------------LEQRESLPIYKLKEQLIQAVHDNQILIVI 577

  Fly   407 GNTGCGKTTQIAQYILDDYICSGQGGY---ANIYVTQPRRISAISVAERVARERCEQLGDTVGYS 468
            |.||.||||||.||:       .:.||   ..|..|||||::|:|||:||:.|....||..|||:
Zfish   578 GETGSGKTTQITQYL-------AEAGYTTRGKIGCTQPRRVAAMSVAKRVSEEYGCCLGQEVGYT 635

  Fly   469 VRFESVFPRPYGAILFCTVGVLLRK--LEAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYP 531
            :|||.. ..|...|.:.|.|:|||:  ::..|...:.|::||.|||.:::|.|..:|:..|....
Zfish   636 IRFEDC-TSPETVIKYMTDGMLLRECLIDPDLGQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRT 699

  Fly   532 DLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDE 596
            |:.:|:.|||:|..|||:||...|:..:|||.:||
Zfish   700 DMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPV------------------------------ 734

  Fly   597 EQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLP 661
                       |:.|.|..|..|               :...|:..:.:|:...  ||.|||||.
Zfish   735 -----------EVLYTKEPETDY---------------LDASLITVMQIHLTEP--PGDILVFLT 771

  Fly   662 G-------WNLIFALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNI 719
            |       ..:::..||     ::..|..:..|||.:|.:|.:.|.::|:|.|.|..|::::|||
Zfish   772 GQEEIDTACEILYERMK-----SLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNI 831

  Fly   720 AETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRA 784
            ||||:|||.|.:|:|....:.|::.|...:........|:...:||.|||||..||.|:.|.:..
Zfish   832 AETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTER 896

  Fly   785 RFQALEDNLT---PEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVDAVIEAEVLLREMRCL 846
            .::  ::.||   ||:.||.|....|::|.:.:..:..|  ..::.||::.:|.|...|..:..|
Zfish   897 AYR--DEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSF--DFMDAPPMETLITAMEQLYTLGAL 957

  Fly   847 DANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEVFSLDIGQRRLANHQ 911
            |....||.|||.:|..|:||.|.||:::....||::.|..:.|..|. ..||.....::.||:.:
Zfish   958 DDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSV-QNVFYRPKDKQALADQK 1021

  Fly   912 KALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGF 976
            ||.......||:.::.....|:..|     ....:|....:|..::....|.::|:|.::.:
Zfish  1022 KAKFHQPEGDHLTLLAVYNSWKNNK-----FSNPWCYENFIQARSLRRAQDIRKQMLGIMDR--- 1078

  Fly   977 PEECMISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKEKRKVLTT--ESKAALLHKTSVNCS 1039
                   |::|. :......:.|..| :|.|.:.| ...|:.::...|  :.:...:|.:|
Zfish  1079 -------HKLDV-VSCGKATVRVQKA-ICSGFFRN-AAKKDPQEGYRTLIDQQVVYIHPSS---- 1129

  Fly  1040 NLAVTFPYP-FFVFGEKIRTRAVSCKQLSMVSPLQVILF 1077
              |:....| :.|:.|.:.|.....::::.:.|..::.|
Zfish  1130 --ALFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEF 1166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634	8/33 (24%)
		DSRM	170..240	CDD:214634	15/81 (19%)
		DEXDc	393..569	CDD:214692	73/180 (41%)
		DEXDc	402..542	CDD:238005	57/144 (40%)
		ATP-synt_B	<584..644	CDD:304375	6/59 (10%)
		Helicase_C	643..772	CDD:278689	45/135 (33%)
		HA2	842..926	CDD:214852	27/83 (33%)
		OB_NTP_bind	974..1078	CDD:285018	18/107 (17%)
dhx8	XP_002663993.1	S1_DHX8_helicase	257..333	CDD:240189	14/52 (27%)
dhx8	XP_002663993.1	HrpA	542..1209	CDD:224557	205/749 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810