Protein Alignment mle and dhx8

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: XP_021336018.2
• Gene: dhx8 / 606595
• ZFINID: ZDB-GENE-050809-39
• Length: 1210
• Species: Danio rerio
• Alignment Length: 1079
• Identity: 260/1079 - (24%)
• Similarity: 442/1079 - (40%)
• Gaps: 234/1079 - (21%)

  Fly    34 LCEVRVEPNTYIGVGNSTNKKDAEKNACRDFVNYLVRVG---KLNTNDVPADAGASGGGPRTGLE 95
            :.|:|.|       |...|..|......|..|..|...|   .|:..||..|.|......|
Zfish   287 ISELRRE-------GRVANVADVVSKGQRVKVKVLSFTGSKTSLSMKDVDQDTGEDLNPNR---- 340

  Fly    96 GAGMAGGSGQQKRVFDGQSGPQDLGEAYRPLNHDGGDGGNRYSVIDRIQEQR--DMNEAEAFDVN 158
             ....||.||::........|.:|...:.|...|           |.::.:|  .:::.|.:::.
Zfish   341 -RRNVGGEGQEESAMRNPDRPTNLNLGHAPEVED-----------DTLERKRLTKISDPEKWEIK 393

  Fly   159 AAIHGNWTIENAKERLNIYKQTNNIRDDYKYTPVGPEHARSFLAELSIYVPALNR---------- 213
            ..|..|..   :||....:.:...|     ...|..|.......||....|...|
Zfish   394 QMIAANVL---SKEEFPDFDEETGI-----LPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMS 450

  Fly   214 --TVTARESGSNKKSASKSCALSLVRQLFHLNVIEPFSGTLKKKKDEQLKPYPVKLSPNLINKID 276
              .:.....||..::|....||:..|:           ...:.:::.::...|:.|:.:.::
Zfish   451 PVKIVKNPDGSLSQAAMMQSALAKERR-----------EVKQAQREAEMDSIPMGLNKHWVD--- 501

  Fly   277 EVIKGLDLPVVNPRNIKIELDGPPIPLIVNLSRIDSSQQDGEKRQESSVIPWAPPQANWNTWHAC 341
                  .||.|:.|.|...:.|                        ..::|...|:...:.:...
Zfish   502 ------PLPDVDGRQIAANMRG------------------------IGMMPNDIPEWKKHAFGGN 536

  Fly   342 NIDEGELATTSIDDLSMDYERSLRDRRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIR 406
            ....|:....||                        ||.||.|||..::.:::.|::||.::|:.
Zfish   537 KASYGKKTQLSI------------------------LEQRESLPIYKLKEQLIQAVHDNQILIVI 577

  Fly   407 GNTGCGKTTQIAQYILDDYICSGQGGY---ANIYVTQPRRISAISVAERVARERCEQLGDTVGYS 468
            |.||.||||||.||:       .:.||   ..|..|||||::|:|||:||:.|....||..|||:
Zfish   578 GETGSGKTTQITQYL-------AEAGYTTRGKIGCTQPRRVAAMSVAKRVSEEYGCCLGQEVGYT 635

  Fly   469 VRFESVFPRPYGAILFCTVGVLLRK--LEAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYP 531
            :|||.. ..|...|.:.|.|:|||:  ::..|...:.|::||.|||.:::|.|..:|:..|....
Zfish   636 IRFEDC-TSPETVIKYMTDGMLLRECLIDPDLGQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRT 699

  Fly   532 DLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDE 596
            |:.:|:.|||:|..|||:||...|:..:|||.:||
Zfish   700 DMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPV------------------------------ 734

  Fly   597 EQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLP 661
                       |:.|.|..|..|               :...|:..:.:|:...  ||.|||||.
Zfish   735 -----------EVLYTKEPETDY---------------LDASLITVMQIHLTEP--PGDILVFLT 771

  Fly   662 G-------WNLIFALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNI 719
            |       ..:::..||     ::..|..:..|||.:|.:|.:.|.::|:|.|.|..|::::|||
Zfish   772 GQEEIDTACEILYERMK-----SLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNI 831

  Fly   720 AETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRA 784
            ||||:|||.|.:|:|....:.|::.|...:........|:...:||.|||||..||.|:.|.:..
Zfish   832 AETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTER 896

  Fly   785 RFQALEDNLT---PEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVDAVIEAEVLLREMRCL 846
            .::  ::.||   ||:.||.|....|::|.:.:..:..|  ..::.||::.:|.|...|..:..|
Zfish   897 AYR--DEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSF--DFMDAPPMETLITAMEQLYTLGAL 957

  Fly   847 DANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEVFSLDIGQRRLANHQ 911
            |....||.|||.:|..|:||.|.||:::....||::.|..:.|..|. ..||.....::.||:.:
Zfish   958 DDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSV-QNVFYRPKDKQALADQK 1021

  Fly   912 KALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGF 976
            ||.......||:.::.....|:..|     ....:|....:|..::....|.::|:|.::.:
Zfish  1022 KAKFHQPEGDHLTLLAVYNSWKNNK-----FSNPWCYENFIQARSLRRAQDIRKQMLGIMDR--- 1078

  Fly   977 PEECMISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKEKRKVLTT--ESKAALLHKTSVNCS 1039
                   |::|. :......:.|..| :|.|.:.| ...|:.::...|  :.:...:|.:|
Zfish  1079 -------HKLDV-VSCGKATVRVQKA-ICSGFFRN-AAKKDPQEGYRTLIDQQVVYIHPSS---- 1129

  Fly  1040 NLAVTFPYP-FFVFGEKIRTRAVSCKQLSMVSPLQVILF 1077
              |:....| :.|:.|.:.|.....::::.:.|..::.|
Zfish  1130 --ALFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEF 1166

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683	9/35 (26%)
		DSRM_DHX9_rpt2	167..241	CDD:380684	15/85 (18%)
		DEXHc_DHX9	326..559	CDD:350730	80/237 (34%)
		HrpA	378..>889	CDD:441249	168/525 (32%)
		OB_NTP_bind	1002..1079	CDD:400182	15/79 (19%)
dhx8	XP_021336018.2	None