DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mle and DHX35

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_068750.2	Gene:	DHX35 / 60625	HGNCID:	15861	Length:	703	Species:	Homo sapiens

Alignment Length:	703	Identity:	198/703 - (28%)
Similarity:	318/703 - (45%)	Gaps:	117/703 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   381 REKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILD-DYICSGQGGYANIYVTQPRRI 444
            |:|||:..:|:.||..|.:...|:|.|.|||||:|||.||:.: .:...|:    .:.||||||:
Human    51 RQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGR----VVGVTQPRRV 111

  Fly   445 SAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRKL--EAGLRGVSHIIVD 507
            :|::||.|||.||...||..|||.:||:....:....|.|.|.|:|:|::  :..|...|.|::|
Human   112 AAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQLATRIKFLTDGMLVREMMVDPLLTKYSVIMLD 176

  Fly   508 EIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFG----------ICPVLEVPGR 562
            |.|||.:.:|..:.:|:.:.....||.:|:.|||:|..||..:|.          .|.:|.|.||
Human   177 EAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFFNQNETSDPARDTCVILTVEGR 241

  Fly   563 AFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAM 627
            .|||..|:|:.  .:.|::.|.        ||...::...:.|
Human   242 TFPVDIFYLQS--PVPDYIKST--------VETVVKIHQTEGD---------------------- 274

  Fly   628 AMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGW-------NLIFALMKFLQNTNIFGDTSQY 685
                                      |.:|.||.|.       :::....:.|..|   |.....
Human   275 --------------------------GDVLAFLTGQEEVETVVSMLIEQARALART---GMKRHL 310

  Fly   686 QILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLT 750
            ::||.::.:|..||.||||.|...|.|:|::||:|||||||..||:|||....:::.:.....:.
Human   311 RVLPMYAGLPSFEQMKVFERVSRSVRKVIVATNVAETSITISGIVYVIDCGFVKLRAYNPRTAIE 375

  Fly   751 SYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLLRLG 815
            ....|..|:.:..||.||.||.|.|.|:.|.:...|..|..:..|||.|:.|..:.|.:|.|.:.
Human   376 CLVVVPVSQASANQRAGRGGRSRSGKCYRLYTEEAFDKLPQSTVPEMQRSNLAPVILQLKALGID 440

  Fly   816 SI--HHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELT-PLGRLLARLPIEPRLGKMMVLGAV 877
            ::  .||:|    |||..::::|..||..:..||.:..|| |||..:|..|:.|...||::....
Human   441 NVLRFHFMS----PPPAQSMVQALELLYALGGLDKDCRLTEPLGMRIAEFPLNPMFAKMLLESGN 501

  Fly   878 FGCA-DLMAIMASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGEH 941
            |||: ::::|.|...  ...:|.:...|:..|.........:..||:.|:...:.:.:..:..:.
Human   502 FGCSQEILSIAAMMQ--IQNIFVVPPNQKSHAIRVHRKFAVEEGDHLTMLNIYEAFIKHNKDSKW 564

  Fly   942 MEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLALLCL 1006
            .:..|.::|||..:.     ..::||..||          :..:|..:....||  |:.|..:..
Human   565 CQEHFLNYKGLVRAA-----TVREQLKKLL----------VKFQVPRKSSEGDP--DLVLRCIVS 612

  Fly  1007 GLYPNICVHKEKRKVLTTESKAAL-LHKTSVNCSNLAVTFPYPFFVFGEKIRT 1058
            |.:.|...........|......| :|..||    |....|..:.::.|.|:|
Human   613 GFFANAARFHSTGAYRTIRDDHELHIHPASV----LYAEKPPRWVIYNEVIQT 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634
		DEXDc	393..569	CDD:214692	72/188 (38%)
		DEXDc	402..542	CDD:238005	56/142 (39%)
		ATP-synt_B	<584..644	CDD:304375	3/59 (5%)
		Helicase_C	643..772	CDD:278689	42/135 (31%)
		HA2	842..926	CDD:214852	22/85 (26%)
		OB_NTP_bind	974..1078	CDD:285018	17/86 (20%)
DHX35	NP_068750.2	DEXDc	53..224	CDD:214692	68/174 (39%)
		DEXDc	73..211	CDD:238005	56/141 (40%)
		DEAH box	176..179		2/2 (100%)
		HELICc	301..396	CDD:197757	36/97 (37%)
		HA2	465..549	CDD:214852	22/85 (26%)
		OB_NTP_bind	584..683	CDD:285018	21/94 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810