DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and dhx30

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	XP_021322211.1	Gene:	dhx30 / 570735	ZFINID:	ZDB-GENE-130530-833	Length:	1173	Species:	Danio rerio

Alignment Length:	1192	Identity:	349/1192 - (29%)
Similarity:	557/1192 - (46%)	Gaps:	197/1192 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LCEVRVEPNTYIGVGNSTNKKDAEKNACRDFVNYLVRVGKLNTNDVPADAGASGGGPRTGLEGAG 98
            |..||:|..     |..:.|::||:||....:..|..:|..              .|....:.||
Zfish   103 LWPVRIETE-----GFGSRKQEAERNAAAAALQKLCELGVY--------------APGKRRQEAG 148

  Fly    99 MAGGSGQQKRVFDGQSGPQDLGEAYRPLNHDGGDGGNRYSVIDR----IQEQRDMNEAEA-FDVN 158
            |.....:|..:.|.:..           ||.......:.:..||    ::|...::||.| |...
Zfish   149 MLRMKDRQTSLCDNEEE-----------NHLQSLPIQKKTQKDRAHGLVEEDSRLSEALAIFPRP 202

  Fly   159 AAIHGNWTIENAKERLNIYKQTNNIRDDYKYTPVGPEHARSFLAELSIYVPALNRTVTARESGSN 223
            ..:.|:        .:.:...:..:||..:|...|   .:..:.||::..|.   .:|...||..
Zfish   203 RTLLGS--------VIQVATSSCRVRDLLQYKTSG---GKVKVCELNVLWPT---PMTFTASGRR 253

  Fly   224 KKSASKSCALSLVRQLFHLNVIEPFSGTLKKKKDEQLKPYP-VKLSPNLINKIDEVIK---GLDL 284
            :..|..:.|.....:|..||::           |||.||.. .:...:.:.:..|..:   .:.:
Zfish   254 RLEAEANAAALACLKLKELNLL-----------DEQNKPLTHARYHQDQVREAGERHRQPCRMQI 307

  Fly   285 PVVNPRNIKIELDGPPIPLIVNLSRIDSSQQDGEKRQESSVIPWAPPQANWNTWHACNIDEGELA 349
            |......|:..|...|:...|      ....|.|:.|.||:           :..|.:.||.|..
Zfish   308 PEQLELRIQQYLSQYPVEAEV------QKLWDEEEHQSSSI-----------STAADDYDEDEFI 355

  Fly   350 TTSIDDLSMDYERSLRDRRQNDNEYRQFLEFRE-------KLPIAAMRSEILTAINDNPVVIIRG 407
            |.:|  .|..| |:|..:.......|....::.       :||:.|.:..||.|:..:.||:|.|
Zfish   356 TDAI--TSKPY-RALEPKEAEHLSQRLLSMWKRVGPARGAELPVDAHKESILEAVRSSQVVVISG 417

  Fly   408 NTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFE 472
            .|||||||:|.:::|:|.:..|:|...|:.|||||||||:|||:|||.|....|...|||.||.|
Zfish   418 ETGCGKTTRIPRFLLEDGVLRGEGAECNVLVTQPRRISAVSVAQRVAHEIGPALQHCVGYQVRLE 482

  Fly   473 SVFP-RPYGAILFCTVGVLLRKLEAG--LRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLH 534
            |..| |..||:||.|:||||:||::.  |.|:||:||||:|||||.:|.||.:||.::...|:|.
Zfish   483 SRPPERSGGALLFLTLGVLLKKLQSNPRLEGISHVIVDEVHERDVQTDLLLHLLRCVLSLRPELK 547

  Fly   535 VILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQL 599
            |:||||:.|:.:.::|||.||||.|||...||:..||||:        ..:|||...::...:
Zfish   548 VLLMSASGDSQRLAQYFGGCPVLRVPGFMHPVRARFLEDM--------QLDSRRPLLDMGSTQ-- 602

  Fly   600 LSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVS--FELLEALLMHIKSKNIPGAILVFLPG 662
                               :|.:.|..|.. .|::|:  .:|:..::.||.....|||:|.||||
Zfish   603 -------------------WSAEVRGRMGK-EENNVTPDLDLVADVIDHIHRTGEPGAVLCFLPG 647

  Fly   663 WNLIFALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITID 727
            |..|.|:.:.|:....:...||. |||.||.:...||:.||:..|.|..||:|:|||||||||||
Zfish   648 WQEIKAVQQQLEEKQAYRSGSQI-ILPLHSSMAVSEQQVVFQRPPAGQRKIVLATNIAETSITID 711

  Fly   728 DIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDN 792
            |||.|:|....:.:.:.....:::..|||.|:.|:.||:|||||.:||..:.|..|.:.:.:|..
Zfish   712 DIVHVVDAGVQKEQNYDPRTKVSALNTVWISQANVTQRRGRAGRCQPGHSYHLFPRKQLERMEPF 776

  Fly   793 LTPEMFRTPLHEMALTIKLLRLGSIH-------HFLSKALEPPPVDAVIEAEVLLREMRCLDAND 850
            ..||:.||||..:.:..|      ||       .|||:.|:.|...||..|...|.::..|||::
Zfish   777 PVPEILRTPLESVVMQAK------IHCPESKAEDFLSQVLDSPDTQAVRTAVKNLMDIGVLDASE 835

  Fly   851 ELTPLGRLLARLPIEPRLGKMMVLGAVFGCAD-LMAIMASYSSTFSEVFSLDIGQRRLANHQKA- 913
            :|||||..::.:..:|||||::|..|:|.|.. :::::|..:   .:.|...:..|.|.:..||
Zfish   836 DLTPLGHHVSCMSCDPRLGKVLVFSALFSCVQPVLSVVACLT---RDPFYNSLQNRTLVSKAKAE 897

  Fly   914 LSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFPE 978
            |||:..||::......|.||.:..|....:  :.|...|..:::..|....||..|.|.:||..:
Zfish   898 LSGSSGSDYLVFSRVVQSWREQHSRDSRQD--YLDKHTLSGASLRFIHGLMQQFSDNLCEAGLVD 960

  Fly   979 ---ECM-ISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKEKRKVLT-------------TES 1026
               ||: :|..|:::...:..:..|.||    |||||:.  :.|:.|:|             |||
Zfish   961 HSAECLRLSSPVNQQSKEEQLITAVLLA----GLYPNLI--QVKKGVVTKSGRFRAENVSFRTES 1019

  Fly  1027 KAALLHKTSVNCSNLAVTFPYPFFVFGEKIRTRAVSCKQLSMVSPLQVILF----------GSR- 1080
            ...|||::|||.....:...:..| |.....:..|..:..::|.||.::|.          |.|
Zfish  1020 GPVLLHRSSVNRDKQHLWSRWLTF-FSAVKSSGQVFIRDSTVVHPLALLLLTDCDLSERVVGDRV 1083

  Fly  1081 KIDLAANNIVRVDNWLNFDIEPELAAKIGALKPALEDLI-----TVACDNPSDILRLEEPYAQLV 1140
            ::.|....::|   |   :..|.:...:..|:.:::.:|     ...|.:.|:    :...::|:
Zfish  1084 EVALPGPALIR---W---EFSPAVWELLWDLRASIQAMIYRKLRQSECKSSSE----QRKDSELI 1138

  Fly  1141 KVVKDLCVKSAGDFGLQRESGI 1162
            .::.||...:..|....:|..:
Zfish  1139 DLLVDLLNNTDPDVSRDQEDAL 1160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634	10/33 (30%)
		DSRM	170..240	CDD:214634	12/69 (17%)
		DEXDc	393..569	CDD:214692	95/178 (53%)
		DEXDc	402..542	CDD:238005	79/142 (56%)
		ATP-synt_B	<584..644	CDD:304375	9/61 (15%)
		Helicase_C	643..772	CDD:278689	57/128 (45%)
		HA2	842..926	CDD:214852	28/85 (33%)
		OB_NTP_bind	974..1078	CDD:285018	33/130 (25%)
dhx30	XP_021322211.1	HrpA	371..>929	CDD:224557	225/599 (38%)
dhx30	XP_021322211.1	OB_NTP_bind	947..1069	CDD:311586	36/128 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820