DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mle and dhx40

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	XP_021322026.1	Gene:	dhx40 / 570225	ZFINID:	ZDB-GENE-080507-1	Length:	734	Species:	Danio rerio

Alignment Length:	786	Identity:	214/786 - (27%)
Similarity:	356/786 - (45%)	Gaps:	132/786 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   367 RRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQG 431
            :|.::.|:.:    .:||||...:.:::.|:.:|..:|:.|.||.|||||:.||:..    :|..
Zfish     5 KRSSETEHHE----SKKLPIYQYKDKLVQAVEENTFLIVTGETGSGKTTQLPQYLYK----AGLS 61

  Fly   432 GYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRKL-- 494
            ....|.||||||::||:||:||:.|...:||:.|||.|||:....:. ..|.:.|.|.|||::
Zfish    62 RNGRIGVTQPRRVAAITVAQRVSSEMQVRLGEEVGYQVRFDDCSTKD-TMIKYMTDGCLLREILA 125

  Fly   495 EAGLRGVSHIIVDEIHERDVNSDFLLVILRDMV-----DTYPDLHVILMSATIDTTKFSKYFGIC 554
            :..|...|.:|:||.|||.:|:|.||.:|:..:     .....|.|::||||::|.|.|.::|.|
Zfish   126 DPSLTQYSIVILDEAHERSLNTDVLLGLLKKTLLKGSRGNKTPLKVVVMSATLETEKLSSFYGNC 190

  Fly   555 PVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKY 619
            ||..:|||.:||::.|..                           |...||:
Zfish   191 PVFTIPGRTYPVKETFCN---------------------------LIGPKDK------------- 215

  Fly   620 SQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPG-------WNLIFALMKFLQNTN 677
                        ||.|..:.:..:.:.:.:....|.|||||.|       .:|:|...:.|....
Zfish   216 ------------ESSVYVKEVVKMTLDVHTNEAAGDILVFLTGQSEIEKACDLLFEKAEILDYRY 268

  Fly   678 IFGDTS--QYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARM 740
            ...|.|  ...||..:..:|.|:||::|:|.|:||.|.:::||||.||:|||.|.:::|....:.
Zfish   269 DVHDRSVDGLLILSLYGSMPTDQQRQIFQPAPKGVRKCVVATNIAATSLTIDGIRYIVDSGFVKQ 333

  Fly   741 KLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLT-PEMFRTPLHE 804
            ....|...|.....|..||:..:||.|||||...|.||.:.|:..:.......| ||:.||.|..
Zfish   334 LNHNSRVGLDILEVVPISKSEAQQRAGRAGRTAAGKCFRIYSKDFWDTCMPEYTIPEIQRTSLTS 398

  Fly   805 MALTIKLLRLGSIHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLG 869
            :.||:|.|.:..:..|  ..|:.|....::.|...|.:...:|...|:|.||||:...|:.|.|.
Zfish   399 VILTLKCLGVHDVIRF--PYLDCPEERFILTALKQLYQYDAIDRRGEVTKLGRLMVEFPLPPNLT 461

  Fly   870 KMMVLGAVFGCADLM---AIMASYSSTFSEVFSLDIGQRRLANHQK--ALSGTKCSDHVAMIVAS 929
            :.::..|..||.|:|   |.|.|..:.|......:..:.....|::  |.||.. :|.:.::...
Zfish   462 RALLKAAALGCEDIMLPVAAMLSVENIFIRPGKPEKQKEAEVRHKEIAACSGGS-NDFLMLLCVF 525

  Fly   930 QMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDD 994
            :..|..:......:..:..|:.:: |..:|....::.||.|.||..||.         ||.:|..
Zfish   526 EKCRASENPSAWCKENWIHWRAVK-SAFSVETQLREILLRLKQQKDFPH---------ERFEGSR 580

  Fly   995 PVLDVSLALLCLGLYPNICVHKEKRKVLTTE--SKAALLHKTSVNCSNLAVTFPYPFFVFGEKIR 1057
            .  ::....||||.:.|:......:...|.:  ..:.|:|.:|  |            :||::::
Zfish   581 S--ELLRQCLCLGYFTNVARRSIGKSFCTMDGHGSSVLIHPSS--C------------LFGQELQ 629

  Fly  1058 TRAVSCKQLSMVSPLQVILFGSRKIDLAANNIVRVDNWLNFDIEPELAAKIGALKPALEDLITVA 1122
                          |..|:|  ..:.:.:...||....:.:|...:|..|:..:.  :.:|.:||
Zfish   630 --------------LDWIIF--HDVLVTSRVYVRTVCPIRYDWVKDLLPKLHEID--VYELSSVA 676

  Fly  1123 CDNPSD 1128
            .:..:|
Zfish   677 REEVTD 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634
		DEXDc	393..569	CDD:214692	73/182 (40%)
		DEXDc	402..542	CDD:238005	58/146 (40%)
		ATP-synt_B	<584..644	CDD:304375	6/59 (10%)
		Helicase_C	643..772	CDD:278689	46/137 (34%)
		HA2	842..926	CDD:214852	24/88 (27%)
		OB_NTP_bind	974..1078	CDD:285018	19/105 (18%)
dhx40	XP_021322026.1	HrpA	15..696	CDD:224557	212/772 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810