DRSC/TRiP Functional Genomics Resources

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Protein Alignment mle and DHX33

DIOPT Version :9

Sequence 1:NP_476641.1 Gene:mle / 35523 FlyBaseID:FBgn0002774 Length:1293 Species:Drosophila melanogaster
Sequence 2:NP_064547.2 Gene:DHX33 / 56919 HGNCID:16718 Length:707 Species:Homo sapiens


Alignment Length:641 Identity:190/641 - (29%)
Similarity:301/641 - (46%) Gaps:110/641 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   367 RRQ-------NDNEYRQFLEF-REKLPIAAMRSEILTAIN--DNPVVIIRGNTGCGKTTQIAQYI 421
            |||       :.:.|.:.:|. |..|||...|.::|..:.  ||.|:|  |.||.||||||.||:
Human    49 RRQQPPLAQPSASPYPEAVELQRRSLPIFQARGQLLAQLRNLDNAVLI--GETGSGKTTQIPQYL 111

  Fly   422 LDDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCT 486
            .:..| |.||   .|.||||||::|||:|.||:.|:..:||..|||:|||:.|.... ..|.|.|
Human   112 YEGGI-SRQG---IIAVTQPRRVAAISLATRVSDEKRTELGKLVGYTVRFDDVTSED-TRIKFLT 171

  Fly   487 VGVLLRKL--EAGLRGVSHIIVDEIHERDVNSDFLLVIL------RDMVDTYPDLHVILMSATID 543
            .|:|||:.  ::.||..|.:|:||.|||.:::|.|..::      |..:...| |.||:||||:|
Human   172 DGMLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKELGKLP-LKVIVMSATMD 235

  Fly   544 TTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAE 608
            ...||:||...|||.:.||..|:|.|:.:.  ...|::.:|                        
Human   236 VDLFSQYFNGAPVLYLEGRQHPIQVFYTKQ--PQNDYLHAA------------------------ 274

  Fly   609 INYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGA--ILVFLPGWNLIFALMK 671
                                          |:....:|   :..|.:  |||||.|...|.|:.|
Human   275 ------------------------------LVSVFQIH---QEAPSSQDILVFLTGQEEIEAMSK 306

  Fly   672 FLQNTNIFGDTSQY--------QILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDD 728
            ..:      |.:::        .:||.::.:|..:|.:||:..|:|..|:|:|||||||||||..
Human   307 TCR------DIAKHLPDGCPAMLVLPLYASLPYAQQLRVFQGAPKGYRKVIISTNIAETSITITG 365

  Fly   729 IVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNL 793
            |.:|:|....:.|.:...:.|...|....|||...||.|||||...|.|:.|.:...|:..:...
Human   366 IKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTGRAGREDSGICYRLYTEDEFEKFDKMT 430

  Fly   794 TPEMFRTPLHEMALTIKLLRLGSI--HHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLG 856
            .||:.|..|..:.|.:..:::.::  ..|:||. .|..:.|.|....||..:...|....|||:|
Human   431 VPEIQRCNLASVMLQLLAMKVPNVLTFDFMSKP-SPDHIQAAIAQLDLLGALEHKDDQLTLTPMG 494

  Fly   857 RLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSD 921
            |.:|..|:||:..|.:::...|.|.:.:..:.|..|..|.:.:....:..:...:|....:: .|
Human   495 RKMAAFPLEPKFAKTILMSPKFHCTEEILTIVSLLSVDSVLHNPPSRREEVQGVRKKFISSE-GD 558

  Fly   922 HVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFP 977
            |:.::   .::|..|..|.:.:  :|....:....|.::.:.:.||.|:..:...|
Human   559 HMTLL---NIYRTFKNLGGNKD--WCKENFVNSKNMTLVAEVRAQLRDICLKMSMP 609

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mleNP_476641.1 DSRM 4..68 CDD:214634
DSRM 170..240 CDD:214634
DEXDc 393..569 CDD:214692 82/185 (44%)
DEXDc 402..542 CDD:238005 66/147 (45%)
ATP-synt_B <584..644 CDD:304375 2/59 (3%)
Helicase_C 643..772 CDD:278689 48/138 (35%)
HA2 842..926 CDD:214852 19/83 (23%)
OB_NTP_bind 974..1078 CDD:285018 1/4 (25%)
DHX33NP_064547.2 Required for nucleolar location. /evidence=ECO:0000269|PubMed:26100019 1..80 9/30 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..64 3/14 (21%)
HrpA 67..695 CDD:224557 186/623 (30%)
DEXDc 92..234 CDD:238005 67/149 (45%)
DEAH box 194..197 2/2 (100%)
Helicase_C 291..408 CDD:278689 45/122 (37%)
HA2, required for interaction with EIF3G and RPL26. /evidence=ECO:0000269|PubMed:26100019 471..562 22/91 (24%)
HA2 478..563 CDD:214852 20/85 (24%)
Critical for rDNA-binding. /evidence=ECO:0000250 547..558 1/11 (9%)
OB_NTP_bind 597..697 CDD:285018 4/13 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1643
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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