DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and dhx9

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_001188373.1	Gene:	dhx9 / 568043	ZFINID:	ZDB-GENE-070912-171	Length:	1270	Species:	Danio rerio

Alignment Length:	1315	Identity:	671/1315 - (51%)
Similarity:	886/1315 - (67%)	Gaps:	76/1315 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DIKSFLYQFCAKSQIEPKFDIRQTGPKNRQRFLCEVRVEPNTYIGVGNSTNKKDAEKNACRDFVN 66
            |||:|||.:|.|.::.|.:|||..|.||||:|:||||||..:|||:|||||||||:.||.|||||
Zfish     3 DIKNFLYAWCGKKKLTPNYDIRAAGNKNRQKFMCEVRVESYSYIGMGNSTNKKDAQSNAARDFVN 67

  Fly    67 YLVRVGKLNTNDVPADAGASGGGPRTGLEGAGMAGGSGQ------------QKRVFDGQSG---- 115
            ||||..:::..:|||...:...||..|  |....||.|.            .|:..:...|
Zfish    68 YLVRTKEISPGEVPALGVSVPDGPSEG--GNDDGGGFGNLPSNCPLPPHLAVKKELESCEGSAPV 130

  Fly   116 PQDLGEAYRPLNHDGGD-GGNRYSVIDRIQEQ--RDMNEAEAFDVNAAIHGNWTIENAKERLNIY 177
            |...|..|...|:...: |.|......:.:||  :...|:|..|:||.:|||||::|||.|||.:
Zfish   131 PGVTGLGYSGRNNAPWERGANLQEYYSKKEEQDAKATYESEEVDLNAGLHGNWTLDNAKARLNQF 195

  Fly   178 KQTNNIRDDYKYTPVGPEHARSFLAELSIYVPALNRTVTARESGSNKKSASKSCALSLVRQLFHL 242
            .|....:.||||:.|||:|.|||:||::|:|..|.|.|||||.||.||.|::||||||||||:||
Zfish   196 FQKEKNQTDYKYSQVGPDHNRSFIAEMTIFVRQLGRRVTAREHGSTKKLAAQSCALSLVRQLYHL 260

  Fly   243 NVIEPFSGTLKKKKDEQLKPYPVKLSPNLINKIDEVIKGLDL----PVVNPRNIKIELDGPPIPL 303
            .|||.::|..|||:.|.:..|||.::.::.:::..|::.|.:    |..:|.:        |:.|
Zfish   261 GVIEAYTGQTKKKEGESVDVYPVNVNDDVQHQLYSVVQELGIHIPPPPQDPNS--------PVSL 317

  Fly   304 IV-NLSRIDSSQQDGEKRQESSVIPWAPPQANWNTWHACNIDEGELATTSIDDLSMDYERSLRDR 367
            :. .|:..:.||    ::..:.|:||:|||.|||.|.:.|||||.||..:.:.:|.|....|..:
Zfish   318 VQGKLAHFEPSQ----RQSMAGVVPWSPPQVNWNPWTSSNIDEGPLAFCTPEQISNDLLNELNYQ 378

  Fly   368 RQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGG 432
            .:.|...:..|..|.:||:...:.:|::.|.:||||||||.||||||||:.|||||::|..|:..
Zfish   379 LEQDQNLQTILTERSQLPVKNFQEQIMSTIYNNPVVIIRGATGCGKTTQVPQYILDEFIKGGRAS 443

  Fly   433 YANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRKLEAG 497
            ..||.|||||||||:||||||:.||.|.:|.:.||||||||..|||:.:||||||||||||||:|
Zfish   444 DCNIVVTQPRRISAVSVAERVSFERGEDVGKSCGYSVRFESFLPRPHASILFCTVGVLLRKLESG 508

  Fly   498 LRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGR 562
            :||:||:|||||||||:|:|||||:|||:|..|||:.|||||||||||.|.:||..|||:||.||
Zfish   509 IRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPDVRVILMSATIDTTMFKEYFFNCPVIEVHGR 573

  Fly   563 AFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAM 627
            |.|||::||||.||||.|||.... ||||:.:||    ..|:|   :|.|.:|..:||.:|:.||
Zfish   574 AHPVQEYFLEDCIQMTQFVPPPMD-RKRKDKDDE----GGDED---VNCNVICGSEYSPETKRAM 630

  Fly   628 AMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQNTNIFGDTSQYQILPCHS 692
            :.|:|.:.||||:||||.:|::..:|||:||||||||||:::.|.|:....||. .||:|||.||
Zfish   631 SQLNEKETSFELIEALLKYIETLEVPGAVLVFLPGWNLIYSMQKHLEMNPHFGG-HQYRILPLHS 694

  Fly   693 QIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWA 757
            ||||:|||:||||||:||||:|||||||||||||:|:|||:|.||.::||||||||:|:||||||
Zfish   695 QIPREEQRRVFEPVPDGVTKVILSTNIAETSITINDVVFVLDSCKQKVKLFTSHNNMTNYATVWA 759

  Fly   758 SKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHFLS 822
            |||||||||||||||||||||.|||||||:.||.::|||:|||||||:||:|||||||.|.:|||
Zfish   760 SKTNLEQRKGRAGRVRPGFCFHLCSRARFEKLETHMTPEIFRTPLHEVALSIKLLRLGGIGNFLS 824

  Fly   823 KALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIM 887
            ||:||||:|||||||..|||:..||:|||||||||:||:|||||||||||::|.:|...|.:..:
Zfish   825 KAIEPPPLDAVIEAEHTLRELDALDSNDELTPLGRILAKLPIEPRLGKMMIMGCIFNVGDAVCTI 889

  Fly   888 ASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGL 952
             |.::.|.|.|..:  .:||....:..:|::.|||||::...|.|...:..||..|.|||:.|.|
Zfish   890 -SAATCFPEPFISE--GKRLGFVHRNFAGSRFSDHVALLSVFQAWDEVRVGGEDAEIRFCEHKRL 951

  Fly   953 QMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKE 1017
            .|.|:.:.|:||.||.::|...||||||:: ::|...: |.|..||:.::||..|.|||:|.|||
Zfish   952 NMPTLRMTWEAKVQLKEILVNVGFPEECLL-NQVFNNV-GPDNNLDLVISLLTFGSYPNVCYHKE 1014

  Fly  1018 KRKVLTTESKAALLHKTSVNC--SNLAVTFPYPFFVFGEKIRTRAVSCKQLSMVSPLQVILFGSR 1080
            |||:||||.:.||:||:||||  ||..:.:|.|||||||||||||:|.|.:::|||||:|||||:
Zfish  1015 KRKILTTEGRNALIHKSSVNCPFSNHDLKYPSPFFVFGEKIRTRAISAKSMTLVSPLQLILFGSK 1079

  Fly  1081 KIDLAANNIVRVDNWLNFDIEPELAAKIGALKPALEDLITVACDNPSDILRLEEPYAQLVKVVKD 1145
            || .:...:|.:|:|:...|..::||.:..|:..||.|:.....:|..|..|:....:|:.|::.
Zfish  1080 KI-TSNGEVVELDDWIKLQIPHDVAAGVAGLRAGLEALVVEVTKDPEYIRNLDPLNERLLNVIRL 1143

  Fly  1146 LCVKSAGDFGLQRESGILPHQSRQFSDGGGPPKRGRFETGRFTNSSFGRRGNGRTFGGGYGNNGG 1210
            :...|:....|..       .:.:|.||..|||..|.:.|  ....| |.|.|...||||...||
Zfish  1144 VSRPSSAGINLMA-------SNPRFGDGPRPPKMARTDFG--GGGDF-RGGGGYRGGGGYRGGGG 1198

  Fly  1211 GYGNNGGGYGNIGGGY-GNNAGGYGNNGGYGNNGGGYRNNGGGYGNN-GGGYGNKRGGFGDSFES 1273
            || ..||||...|||| |...|||...||    |||||.:||..|:: ||||    ||.|..|..
Zfish  1199 GY-RGGGGYQGGGGGYRGGGGGGYRGYGG----GGGYRGSGGYRGSSGGGGY----GGGGRGFRG 1254

  Fly  1274 NRGSGGGFRNGDQGG 1288
            ..|.|||...|::||
Zfish  1255 GGGGGGGGWGGNRGG 1269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634	41/63 (65%)
		DSRM	170..240	CDD:214634	42/69 (61%)
		DEXDc	393..569	CDD:214692	123/175 (70%)
		DEXDc	402..542	CDD:238005	100/139 (72%)
		ATP-synt_B	<584..644	CDD:304375	24/59 (41%)
		Helicase_C	643..772	CDD:278689	92/128 (72%)
		HA2	842..926	CDD:214852	40/83 (48%)
		OB_NTP_bind	974..1078	CDD:285018	61/105 (58%)
dhx9	NP_001188373.1	DSRM	5..69	CDD:214634	41/63 (65%)
		DSRM	188..258	CDD:214634	42/69 (61%)
		DEXDc	400..580	CDD:214692	123/179 (69%)
		DEXDc	413..553	CDD:238005	100/139 (72%)
		Helicase_C	641..774	CDD:278689	96/133 (72%)
		HA2	844..925	CDD:214852	40/83 (48%)
		OB_NTP_bind	965..1079	CDD:285018	66/115 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582048
Domainoid	1	1.000	224	1.000	Domainoid score	I2495
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1039
Inparanoid	1	1.050	1234	1.000	Inparanoid score	I180
OMA	1	1.010	-	-		QHG45656
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	1	1.000	-	-		FOG0006547
OrthoInspector	1	1.000	-	-		oto39035
orthoMCL	1	0.900	-	-		OOG6_105518
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2487
SonicParanoid	1	1.000	-	-		X4785
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.900