Protein Alignment mle and ythdc2

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: XP_021332046.1
• Gene: ythdc2 / 567114
• ZFINID: ZDB-GENE-220119-1
• Length: 1381
• Species: Danio rerio
• Alignment Length: 1269
• Identity: 352/1269 - (27%)
• Similarity: 538/1269 - (42%)
• Gaps: 354/1269 - (27%)

  Fly   133 GGNRYSVIDRIQEQRDMNEAEAF-DVNAAIHGNWTIENAKERLNI----YKQTNNIRDDYKYTPV 192
            ||.:.::....|.|....:|:.| |:...       |..|..:||    ::.::....|:..:..
Zfish     4 GGQKSNMSSSKQHQASSLKAKGFRDIRID-------EEVKIAVNIALERFQYSDEKELDFPSSLT 61

  Fly   193 GPEHARSFLAELSIYVPALNRTVTARESGSNKKSASKSCALSLVRQLFHLNVIEPFSGTLKKK-- 255
            ..|  |:|:..|            |:..|...||..|.|:..|               |::||
Zfish    62 NSE--RAFIHRL------------AQSLGYISKSRGKGCSRFL---------------TVRKKDG 97

  Fly   256 KDEQLKPYPVKLSPNLINKIDEVIKGLDLPVVNPRNIKIE------LDGPPIPLIVNLSRIDSSQ 314
            .:.|.......|||:....:..:::  ..|:.:....:::      |..||          |::
Zfish    98 MEAQRSSMSCSLSPSCRALVQSLMQ--RFPISSRERSQLQPHAERGLQSPP----------DTT- 149

  Fly   315 QDGEKRQE---SSVIPWAPPQANWNTWHACNIDEGELATTSIDDLSMDYERSLRDRRQNDNEYRQ 376
             |.:.|..   |..||..||                                   ||.:..|..
Zfish   150 -DSKSRTSGRLSHGIPQVPP-----------------------------------RRSSAPELD- 177

  Fly   377 FLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYANIYVTQP 441
              .||:.||:..::.:|:.:|.|:.||::.|.||.||||||.|::|||  ||.......|:.|||
Zfish   178 --AFRKALPVYELQEQIIQSIRDHQVVLVLGETGSGKTTQIPQFLLDD--CSATASPCRIFCTQP 238

  Fly   442 RRISAISVAERVARERCEQLGDTVGYSVRFES-VFPRPYGAILFCTVGVLLRKLEAG---LRGVS 502
            ||::.|:||||||.||.|.:|.||||.:|.|| |.|:.  .:.|||.|||||.|.||   |..|:
Zfish   239 RRLATIAVAERVAAERGENIGQTVGYQIRLESRVSPKT--LLTFCTSGVLLRTLMAGDEALSTVT 301

  Fly   503 HIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQ 567
            |:||||:||||..:||||..:::::...|:|.::|.||.:|.:.|.:|||.|||:.:.|..:.|:
Zfish   302 HVIVDEVHERDGLTDFLLTKMKEVLQKMPNLRLVLSSAALDVSLFMRYFGSCPVIHIKGCPYEVK 366

  Fly   568 QFFLEDIIQMTDF-----------------------------VPSAE------------------ 585
            |.|||||::.|.:                             ||.|:
Zfish   367 QLFLEDILRSTAYTNKDMIKYKKEAQKEESQQCSLSEWCERDVPQADPPERPTVCVLQDNQLLDD 431

  Fly   586 ------SRRKRKEVED------------------------------------------------- 595
                  |:...|:|..
Zfish   432 GGDSVFSQMSEKDVSSLEPWLLREMDSCISSIFLNQDADAFTQLFNLILNENISVDYRHSETSAT 496

  Fly   596 -------------EEQLL----------------------------------------SEDKDEA 607
                         .||||                                        :..:|||
Zfish   497 ALMVSAGRGFVSHTEQLLNMGANINIKASNGWTALDWAKHFKQTEAVDLLESHIWCAEASPQDEA 561

  Fly   608 EINYNK----VCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLIFA 668
            .:..|.    .|||:...|..:  ....:..|..:|:..||..|...:..||:|:||||::.|.:
Zfish   562 SLLQNSSCELSCEDQELLKAYH--HSFDDEKVDLQLILHLLHSICQSSDQGAVLIFLPGYDEIVS 624

  Fly   669 LMKFLQNTNIFGD------TSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITID 727
                |::..:|.|      ..::|:...||.:...:|:||.:..|:||.||||||||||||||:.
Zfish   625 ----LRDQILFDDKRFTEHQQRFQVFVLHSSMQTSDQKKVLKSTPKGVRKIILSTNIAETSITVS 685

  Fly   728 DIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDN 792
            |:|||||..|.:.|.:.:.||:|....||.||.:..||||||||.|||.||.|.||.||..:.::
Zfish   686 DVVFVIDSGKVKEKAYDALNNVTMLKMVWISKASALQRKGRAGRCRPGVCFHLFSRLRFSNMLEH 750

  Fly   793 LTPEMFRTPLHEMALTIKLLRLGS--IHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPL 855
            ..|::.|.||.|:.|..|||...:  :..|||:|.|||.::.|..|..:|:.:..:|..:.||.|
Zfish   751 QIPQLLRMPLQELCLHTKLLAPINCPVAEFLSRAPEPPHINTVKHAVQMLKTIDAMDPWENLTEL 815

  Fly   856 GRLLARLPIEPRLGKMMVLGAVFGCAD-LMAIMASYSSTFSEVFSLDIGQRRLAN-HQKALSGTK 918
            |..||.||:||.||||::...|..|.| ::.|..:.:.....|......|||:|. .::..:...
Zfish   816 GLHLADLPVEPHLGKMVLCAVVLKCLDPVLTIACTLAHREPFVLPAQAAQRRVAMLCRRRFTANT 880

  Fly   919 CSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFPEECMIS 983
            .|||:|::.|.|.|  :|.|.:..|..||:...|..:||.:|...:.|||..|:..||
Zfish   881 FSDHMALLRAFQAW--QKARSDGWERAFCEKNFLSQATMEIIVSMRTQLLGQLRATGF------- 936

  Fly   984 HEVDERIDGDDPVLDVS---------LALLCLGLYPNICVHKEKRKVLTTESKAALLHKTSV--- 1036
              |..|..||  :.||:         .|.|..|:|||: :|::...:...:.|...||.|||
Zfish   937 --VRARGGGD--IRDVNQNSENWAVVKAALVAGMYPNL-IHRDGLSLSGEKEKKVRLHPTSVLSQ 996

  Fly  1037 ---------NCSNLAV-TFPYPFFVFGEKIRT-RAVSCKQLSMVSPLQVILFGS----------- 1079
                     |....|| :.|..:.::.|..|. |..|.:..:.|:||.:.|||.
Zfish   997 PQYKKIPPANGQAAAVDSLPTDWLIYDEMTRAHRIASVRCCTAVTPLTIALFGGGAKLPSSALQE 1061

  Fly  1080 -----RKIDLAANNI----------VRVDNWLNFDIEPELAAKIGALKPALEDLITVACDNPSDI 1129
                 ...|.:.:.:          :.:|:|:||.::||.|..:..|:...:.:......:||..
Zfish  1062 AVLQRGSADSSDSEVEDQCSARQAHLTLDHWINFRLDPETAELVFGLRQRWQSVFLRRIRSPSKA 1126

  Fly  1130 L-RLEEPYAQLVKVVKDLCVKSAGDFGLQRESGI 1162
            . :|:|...:.:..|.....:||   |||:.:||
Zfish  1127 CSQLDESTIRTLVSVLSAEEQSA---GLQQPTGI 1157

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684	16/77 (21%)
		DEXHc_DHX9	326..559	CDD:350730	96/236 (41%)
		HrpA	378..>889	CDD:441249	226/682 (33%)
		OB_NTP_bind	1002..1079	CDD:400182	26/90 (29%)
ythdc2	XP_021332046.1	R3H_DEXH_helicase	36..94	CDD:100077	16/86 (19%)
		PRK11131	169..>1003	CDD:182986	275/860 (32%)
		DEXHc_YTHDC2	183..358	CDD:350745	87/178 (49%)
		ANKYR	<473..>549	CDD:440430	4/75 (5%)
		ANK repeat	496..524	CDD:293786	4/27 (15%)
		SF2_C_RHA	584..739	CDD:350178	67/158 (42%)
		OB_NTP_bind	958..1050	CDD:400182	26/92 (28%)
		YTH	1249..1378	CDD:410979