DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and DHX32

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_060650.2	Gene:	DHX32 / 55760	HGNCID:	16717	Length:	743	Species:	Homo sapiens

Alignment Length:	847	Identity:	184/847 - (21%)
Similarity:	339/847 - (40%)	Gaps:	177/847 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   344 DEGELATTSIDDLSMDYERSLRDRRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGN 408
            ||.|:....      |.|.:..|.....:.|.:.|:.||.|||...:...:..:..|.:||:.|:
Human    28 DEEEVLACE------DLELNPFDGLPYSSRYYKLLKEREDLPIWKEKYSFMENLLQNQIVIVSGD 86

  Fly   409 TGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFES 473
            ..|||:.|:.|:.. :|..|....:..:..||..:.:.:.:|.|||.|....:|..|||.:.||:
Human    87 AKCGKSAQVPQWCA-EYCLSIHYQHGGVICTQVHKQTVVQLALRVADEMDVNIGHEVGYVIPFEN 150

  Fly   474 VFPRPYGAIL-FCTVGVLLRKLEA----GLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDL 533
            .....  .|| :||..:|.|::.:    |..||  ||:|:||||.:.:|.||.:|:|::...|:|
Human   151 CCTNE--TILRYCTDDMLQREMMSNPFLGSYGV--IILDDIHERSIATDVLLGLLKDVLLARPEL 211

  Fly   534 HVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQ 598
            .:|:.|:....:|.:.|:|..||:||..: .||:..:|.:
Human   212 KLIINSSPHLISKLNSYYGNVPVIEVKNK-HPVEVVYLSE------------------------- 250

  Fly   599 LLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGW 663
                                 :||.            |||.:..|:..|......|.|:|||...
Human   251 ---------------------AQKD------------SFESILRLIFEIHHSGEKGDIVVFLACE 282

  Fly   664 NLIFALMKFL-QNTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEG-------VTKIILSTNIA 720
            ..|..:.:.: |.:|:..|..:..::|.:.:    |:..:|:|:.|.       ..:::|:|:..
Human   283 QDIEKVCETVYQGSNLNPDLGELVVVPLYPK----EKCSLFKPLDETEKRCQVYQRRVVLTTSSG 343

  Fly   721 ETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRAR 785
            |..|..:.:.||||:...|.|::.......|......|::..|.||...|....|..|.|.:.
Human   344 EFLIWSNSVRFVIDVGVERRKVYNPRIRANSLVMQPISQSQAEIRKQILGSSSSGKFFCLYTE-- 406

  Fly   786 FQALEDNLTP----EMFRTPLHEMALTIKLLRLGSIHH--FLSKALEPPPVDAVIEAEVLLREMR 844
             :....::||    ||....|..|.|.:|.:.:..:.|  |:::    |..:::::|...|..:.
Human   407 -EFASKDMTPLKPAEMQEANLTSMVLFMKRIDIAGLGHCDFMNR----PAPESLMQALEDLDYLA 466

  Fly   845 CLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCAD---LMAIMASYSSTFSEVFSLDIGQRR 906
            .||.:..|:..|.:::..|::|:|.|.::....|.|.|   .:|.|.:..:.||.|
Human   467 ALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDCVDEVLTIAAMVTAPNCFSHV--------- 522

  Fly   907 LANHQKALSGTKC--------SDHVAMIVASQMWRRE--KQRGEHMEARFCDWKGLQMSTMNVIW 961
              .|....:...|        .||..:|...:.::..  ....|:...::|....|..|.:.:..
Human   523 --PHGAEEAALTCWKTFLHPEGDHFTLISIYKAYQDTTLNSSSEYCVEKWCRDYFLNCSALRMAD 585

  Fly   962 DAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLALLCLGLYPNIC--VHKEKRKVLTT 1024
            ..:.:||:::::...|       ..:......:..|::..|||. |.:..|.  |......::.|
Human   586 VIRAELLEIIKRIELP-------YAEPAFGSKENTLNIKKALLS-GYFMQIARDVDGSGNYLMLT 642

  Fly  1025 ESKAALLHKTSVNCSNLAVTFPYPFFVFGEKIRTRAVSCKQLSMVSPLQVILFGSRKIDLAANNI 1089
            ..:.|.||.    .|..::|...|                        :.:||  .|..::.||.
Human   643 HKQVAQLHP----LSGYSITKKMP------------------------EWVLF--HKFSISENNY 677

  Fly  1090 VRVDNWLNFDIEPELAAKI------GALKPA-LEDLITVACD--NPSDILRLEEPYAQLVKVVKD 1145
            :|:.:    :|.|||..::      ..|.|: .:|::....|  :|...:..|:...:.....:.
Human   678 IRITS----EISPELFMQLVPQYYFSNLPPSESKDILQQVVDHLSPVSTMNKEQQMCETCPETEQ 738

  Fly  1146 LC 1147
            .|
Human   739 RC 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634
		DEXDc	393..569	CDD:214692	58/180 (32%)
		DEXDc	402..542	CDD:238005	48/144 (33%)
		ATP-synt_B	<584..644	CDD:304375	5/59 (8%)
		Helicase_C	643..772	CDD:278689	32/136 (24%)
		HA2	842..926	CDD:214852	20/94 (21%)
		OB_NTP_bind	974..1078	CDD:285018	16/105 (15%)
DHX32	NP_060650.2	Preny group binding site; CAAX box	1..743		184/847 (22%)
		HrpA	12..679	CDD:224557	172/780 (22%)
		DEAD/DEXH domain	146..403		76/323 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900