Protein Alignment mle and dhx34

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: NP_001121805.1
• Gene: dhx34 / 555838
• ZFINID: ZDB-GENE-061207-30
• Length: 1150
• Species: Danio rerio
• Alignment Length: 1041
• Identity: 291/1041 - (27%)
• Similarity: 436/1041 - (41%)
• Gaps: 290/1041 - (27%)

  Fly   219 ESGSNKK--SASKSCALSLVRQLFHLNVIEPFSGTLKKK---------KDEQLKPYPVKLSPNLI 272
            :|...||  :||||.     ||..|:.:.|   |..|||         ||...: |.:.:|
Zfish    51 QSFKAKKEMTASKSS-----RQEKHVALRE---GKAKKKTGCVDLGLPKDYDAR-YRINIS---- 102

  Fly   273 NKIDEVIKGLDLPVVNPRNIKIELDGPPIPLIVNLSRIDSSQQDGEKRQESSVIPWAPPQANWNT 337
                          |..|:|:..|.|.      :..|.:||   |..|||
Zfish   103 --------------VCSRDIEERLAGS------DHRRRESS---GPGRQE--------------- 129

  Fly   338 WHACNIDEGELATTSIDDLSMDYERSLRDRRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPV 402
                 |.:|.||.....|.         :::|:.::..:....::.|||...|.:|:..:..:||
Zfish   130 -----ITDGRLALLHFLDF---------NQKQSFSKLSKLRREQKSLPIFQYRDKIVELVRTHPV 180

  Fly   403 VIIRGNTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGY 467
            |::.|:|||||:||:.||:|       ..|..||..||||||:.||:|:||:.|...|.|..|||
Zfish   181 VVVAGDTGCGKSTQVPQYLL-------ASGINNIACTQPRRIACISLAKRVSFESLNQYGSKVGY 238

  Fly   468 SVRFESVFPRPYGA-ILFCTVGVLLRKL--EAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDT 529
            .:|||:  .|.... :||.|.|:|||::  :|.|.....:||||:|||.::.||||.:||.::..
Zfish   239 QIRFET--SRTLATKLLFLTEGLLLRQIQQDASLGQYQVLIVDEVHERHLHCDFLLGVLRSLLSL 301

  Fly   530 YPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVE 594
            .|||.::||||||:...||.||...|||:||||.||:|..:                    :.:.
Zfish   302 RPDLRLVLMSATINIKLFSSYFNDAPVLQVPGRLFPIQVIY--------------------QPIP 346

  Fly   595 DEEQLLSEDKDEAEINYNKV---CEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAI 656
            .|||:...:|.:.. .|.:|   .:.:|.|:.|                             |.:
Zfish   347 PEEQVSRSEKLDPR-PYLRVLQGIDQRYPQEER-----------------------------GDL 381

  Fly   657 LVFLPGWNLIFALMKFLQN--TNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNI 719
            |:||.|...|..:.:..|.  |:    |.::.:||.||.:...:|.|||:..|.||.|.|:||||
Zfish   382 LLFLSGVAEISTIQEACQTYATH----TQRWIVLPLHSTLSLAQQDKVFDIAPPGVRKCIISTNI 442

  Fly   720 AETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRA 784
            ||||:|||.:.||:|..|.:...|.....:......|.|:.:.|||||||||..||.|:.|.|.:
Zfish   443 AETSVTIDGVRFVVDSGKVKEMSFDPKAKMQRLQEFWISRASSEQRKGRAGRTGPGVCYRLYSES 507

  Fly   785 RFQALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVDAVIEAEVLLREMRCLDAN 849
            .:.|......||:.|..|..:.|.:|.:.||....|  ..::|||..::..|...|||...||.:
Zfish   508 DYDAFAPYPVPEIHRVALDSLILQMKSMGLGDPRTF--TFIDPPPASSIQTAVTYLREQGALDEH 570

  Fly   850 DELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEVFSLDIGQRRLANHQKAL 914
            .|||.:|||||:||::..:|||:|||:||...:.:..:|:..|..|...       |.|.|....
Zfish   571 GELTSIGRLLAQLPVDVVIGKMLVLGSVFNLVEPVLTVAAALSVQSPFL-------RSAQHNPDC 628

  Fly   915 S------GTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQ 973
            |      .:...|...::.....|.:.|........::|..:||:...:..:.:.::|..:||:.
Zfish   629 STARQPLNSNHGDPFTLMNTFNAWVQVKADRGSGSRKWCRRRGLEEQRLYEMVNLRRQFKELLRS 693

  Fly   974 AGFPE--------------------------ECMISHEVDE------------------------ 988
            .|..|                          :....||:.|
Zfish   694 HGLLEDDTGRATEPQDRARRRERFTERQKLHQLKRDHELQENTKRKVLRLEEGLEGDASSGSDAE 758

  Fly   989 --------RIDGDDPVLDV-------------------------SL------ALLCLGLYPNICV 1014
                    |.||.:..:|:                         ||      .|||.||||.:.:
Zfish   759 ESSTSRKKRKDGAEQTMDIQEVKFKLRHNVNELQESAYASAALSSLQQALLKLLLCRGLYPQLAI 823

  Fly  1015 ---HKEKRK----VLTTESK-AALLHKTSVNCSNLAVTF--PYPFFVFGEKIRTRAVSCKQL--- 1066
               |...||    |..|.:| ..::|.|||..|:..|..  .:....||:..|.:.::...|
Zfish   824 PDEHNATRKDSDQVFHTRNKQGVVIHPTSVFASDPEVLHVPEHETSEFGQSNRHQLLAFVTLLET 888

  Fly  1067 --------SMVSPLQVILFGSRKIDLAANNI--------VRVDNWLNFDI-EPELAAKIGALKPA 1114
                    ..|..||.:|       |.||::        :.||.||...: :.:.|.|:  |..|
Zfish   889 NKPYLSNCVRVPALQALL-------LVANSVNSNADCTRLVVDGWLELSLTDGDAALKV--LSSA 944

  Fly  1115 L 1115
            |
Zfish   945 L 945

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684	9/23 (39%)
		DEXHc_DHX9	326..559	CDD:350730	87/235 (37%)
		HrpA	378..>889	CDD:441249	188/518 (36%)
		OB_NTP_bind	1002..1079	CDD:400182	27/97 (28%)
dhx34	NP_001121805.1	HrpA	161..>622	CDD:441249	192/532 (36%)
		OB_NTP_bind	814..910	CDD:400182	26/102 (25%)