Protein Alignment mle and dhx57

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: XP_021336395.2
• Gene: dhx57 / 555250
• ZFINID: ZDB-GENE-030131-4078
• Length: 1425
• Species: Danio rerio
• Alignment Length: 1232
• Identity: 370/1232 - (30%)
• Similarity: 562/1232 - (45%)
• Gaps: 256/1232 - (20%)

  Fly    12 AKSQIEP----KFDIRQTGPK--NRQRFLCEVRVEPNTYIGVGNSTNKKDAEKNACRDFVN---- 66
            :|.|.|.    ||.:|..|.|  ||.:|..:|.          .|:..:|..|.:...|.|
Zfish   311 SKKQSESNQICKFYLRGAGCKFGNRCKFKHQVH----------ESSTSRDFCKASQPGFSNADAP 365

  Fly    67 -YLVRV----GKLNTNDVPADAGASGGGPRTGLEGAGMAGGSGQQKRVFDGQSGPQDLGEAYRPL 126
             |.:.:    |.|.....|..|.:|   ....|.|||....:   :.:| |||  ....|...|:
Zfish   366 IYQLEIRFQPGSLYPFQPPLVAFSS---TDESLSGAGRLSVT---EYLF-GQS--LSAAEEGEPV 421

  Fly   127 NHDGGDGGNRYSVIDRIQEQRDMNEAEAFDVNAAIHGNWTIENAKERLNIYKQTNNIRDDYKYTP 191
                     .|::|..::|...:.|.    ::||.|                         ||:.
Zfish   422 ---------VYTLISSLEEDGPVREL----LSAAHH-------------------------KYSA 448

  Fly   192 VGPEHARSFLAELSIYVPALNRTVTARESGSNKKSASKSCALSLVR-QLFHLNVIEPFSGTLKKK 255
            ..|           :..|.   |||..:|.|||.:...  ..|..| |....::.|..:..:|:|
Zfish   449 PPP-----------VLAPP---TVTPAKSRSNKNNVDN--RTSATRDQSTSTSITEITNHRVKQK 497

  Fly   256 KDEQLKPYPVKLSPNLINKIDEVIKGLD-------LPVVNPRNIKIELDGPPIPLIVNLSRIDSS 313
            :..|:          |...||:|....|       :||.|...:.:.      ..:|..:.|.:.
Zfish   498 EVAQI----------LSEDIDDVQDEEDDEDEEECIPVENESYVNLR------KRMVKKTEIRTE 546

  Fly   314 QQDGEKRQESSVIPWAPPQANWNTWHACNIDEGELATTSIDDLSMDYERSLRDRRQNDNEYRQFL 378
            |...|.::                                  |..:::|....||     |....
Zfish   547 QMQEENKK----------------------------------LCREFKRKRSSRR-----YISMQ 572

  Fly   379 EFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQ-GGYANIYVTQPR 442
            |.|:|||....|..||..:..|.|::|.|.|||||||||.|:|||:::.:|: ...|||..||||
Zfish   573 EQRQKLPAWQKREAILECLVKNQVLVISGMTGCGKTTQIPQFILDNFLQTGRPDRVANIICTQPR 637

  Fly   443 RISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRKLEAG--LRGVSHII 505
            |||||:||.|||:||.|.||.:.||.:|.|:| ......::|||.|||||:||..  |.||:|:|
Zfish   638 RISAIAVATRVAQERAEALGHSTGYQIRLETV-RSSITRLMFCTTGVLLRRLEGDPELSGVTHVI 701

  Fly   506 VDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFF 570
            |||:|||...|||||::|:|::....||.||:||||::...||:||..||.:.:|||.|||:|||
Zfish   702 VDEVHERTEESDFLLLVLKDLIVKRTDLKVIMMSATLNAELFSQYFNNCPCIHIPGRTFPVEQFF 766

  Fly   571 LEDIIQMTDFV------------------PSAESRRKRKEVED---------------------- 595
            |||.|..|.:|                  |...:.:.|..|||
Zfish   767 LEDAIAKTRYVIEDGSPYRRSTKLNRSSGPGGTTGKGRALVEDFDDDGGWSFTSFRNKESVKDSV 831

  Fly   596 -EEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKN---IPGAI 656
             ::||..:|   ..:.|:     .||:.....:|.:....::.:|:|:||..|...:   .|||:
Zfish   832 PDQQLSQQD---LTVRYS-----NYSKSVVKTLAAMDLDKINMDLVESLLEWIVDGDHSYPPGAV 888

  Fly   657 LVFLPGWNLIFALMKFLQNTNIFGD--TSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNI 719
            ||||||...|..|.:.||:..:|.:  |::..:.|.||.:..:||:.||.....||||||:||||
Zfish   889 LVFLPGLAEIKQLYEQLQSNRMFNNRRTNRCVVYPLHSSLSNEEQQAVFTRPQNGVTKIIISTNI 953

  Fly   720 AETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRA 784
            ||||:||||:|:|||..:.:.|.:.:..::.|...||.|:.|..|||||||||..|.||.|.:..
Zfish   954 AETSVTIDDVVYVIDSGRMKEKRYDASRSMESLEDVWVSRANALQRKGRAGRVASGVCFHLFTSH 1018

  Fly   785 RFQ-ALEDNLTPEMFRTPLHEMALTIKLLRLGS---IHHFLSKALEPPPVDAVIEAEVLLREMRC 845
            ||: .|.....||:.|.||.::.|.:|:|.:.:   :....|:.:|||...::..|:..|..:..
Zfish  1019 RFEHHLSQQQLPEIQRVPLEQLCLRVKVLEVFAERPLDSVFSQLIEPPTEGSLEAAKQRLCALGA 1083

  Fly   846 LDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEVFSLDIGQRRLANH 910
            |...:.|||||..||.||::.|:||:|:|||:|.|.| .|:..:.|..|...|.....:|..||.
Zfish  1084 LTDEESLTPLGWHLACLPVDVRIGKLMLLGAIFRCLD-PALTIAASLAFKSPFVSPWDKREEANE 1147

  Fly   911 QKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAG 975
            :|.......|||:|::.|.:.|....|.|.....::|....|.:..:..|...|:|..:||...|
Zfish  1148 KKLAFSLANSDHLALMQAYKGWCNAAQSGFKAGYQYCRENFLSIRGLQEIACLKRQFAELLSDIG 1212

  Fly   976 FPEECMISHEVDERID-GDDPVLDVS--------------LALLCLGLYPNICVHK--------- 1016
            |.::.:.:..:::... |.|.||:.:              .|:||..||||:...:
Zfish  1213 FVKDGLKARVIEKMSSKGSDGVLEATGYEANLNSDNTKLMSAMLCAALYPNVVQVRSPQMKYKLT 1277

  Fly  1017 -----------EKRKVLTTESKAALLHKTSVNCSNLAVTFPYPFFVFGEKIRTRAVSCKQLSMVS 1070
                       |:::.:|....|..:|.:|||.|  ...:..|:.|:.||::|..|..:..|||.
Zfish  1278 SKGAMKMQPKAEEQRFMTKSDGAVHIHPSSVNFS--VRHYDSPYLVYHEKVKTSRVFIRDCSMVC 1340

  Fly  1071 PLQVILFGSRKIDLAANN---IVRVDN-WLNF-DIEPELAAKIGALKPALEDLITVACDNPS 1127
            ...::|||..::::....   |:.:|: |:.| ....|:|..:..|:..|:.|:.....|||
Zfish  1341 VYPMVLFGGGQVNVELQRGQFIISLDDGWIKFAAASHEVAELVKELRWELDQLLEEKIKNPS 1402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683	18/68 (26%)
		DSRM_DHX9_rpt2	167..241	CDD:380684	14/74 (19%)
		DEXHc_DHX9	326..559	CDD:350730	100/235 (43%)
		HrpA	378..>889	CDD:441249	228/563 (40%)
		OB_NTP_bind	1002..1079	CDD:400182	26/96 (27%)
dhx57	XP_021336395.2	None