Protein Alignment mle and dhx29

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: XP_697933.6
• Gene: dhx29 / 553505
• ZFINID: ZDB-GENE-130530-606
• Length: 1377
• Species: Danio rerio
• Alignment Length: 1299
• Identity: 361/1299 - (27%)
• Similarity: 578/1299 - (44%)
• Gaps: 269/1299 - (20%)

  Fly    13 KSQIEPKF-----DIRQTGPKNRQRFLCEVRVEPNTYIGVGNSTNKKDAEKNACRDFVNYLVRVG 72
            |.:..|||     |.:|.|.||:         ||        ...:|...|...:|
Zfish   176 KQKTRPKFQPLQEDRKQQGNKNQ---------EP--------KEEEKPKAKTPVKD--------- 214

  Fly    73 KLNTNDVPADAGASGGGPRTGLEGAGMAGGSGQQKRVFDGQSGPQDLGE--AYRPLNHDGGDGGN 135
                                  :|..|.....:..:..:.||..::..|  .:.|...:..|..:
Zfish   215 ----------------------DGGSMKEWILRYAQQSEDQSSDEEQKEDIVHNPELDEKFDPND 257

  Fly   136 RYSVI---------------------------DRIQE-QRDMNEAEAFDV-NAAIHGNWT----- 166
            ||.::                           |||:. |::|...|:..| |.||....|
Zfish   258 RYLLLTAQLYDAKEMTTTSKAKKDKMGQRAAQDRIRVIQQEMKTLESHPVFNTAIKVKDTPKEEK 322

  Fly   167 ----IENAKERLNI--------------------YKQTNNIRD-DY---KYTPVGPEHARSFLAE 203
                :.:.||.||.                    .|:..:||: ||   .:|...|   :.||.:
Zfish   323 KAAVVTDGKEELNFNLFEQAEAAPAEKNAVAEKKKKEPKDIRNFDYTSRSWTGKSP---KQFLID 384

  Fly   204 L------SIYVPALNRTVTAR-----------------------ESGSNKKSASKSCAL-SLVR- 237
            .      ....|:.|:....|                       |.|...:....:.|| :||:
Zfish   385 WCRKNLPKSPPPSFNKVAAGRYWKCKVRIQRPTDVLEVCPTILTEDGMQAQHLGATLALYNLVKG 449

  Fly   238 QLFHLNVIEPFSGT-LKKKKDEQLKPYPVKLSPNLINK-IDEVIKGLDLPVVNPRNIKIELDGPP 300
            |..|..:...:... |:.:..||.:.....|:   ||| .|:.|..|
Zfish   450 QSVHQLLPPTYRDVWLEWRDGEQKEEEQTLLA---INKPRDQFISRL------------------ 493

  Fly   301 IPLIVNLSRIDSSQQDGEKRQESSVIPWAPPQANWNTWHA-------CNIDEGELATTSIDDLSM 358
                  |:|:...|....:.:...::..|.|:.:|.....       |....|..|...:::.|
Zfish   494 ------LTRLKQQQSLQSQPEPQKLLQDAEPEDSWENLDTQEEQEPQCGAASGGPAGLVVEEAS- 551

  Fly   359 DYERSLRDRRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILD 423
               |.|..:.|.....|:.|:.|::||:...|.::|.|:..:.|::|.|.||.||:|||.|:||:
Zfish   552 ---RRLLLKLQASPLARRLLDERKQLPVFQHREQVLEALRHHRVLVIAGETGSGKSTQIPQFILE 613

  Fly   424 DYICSGQGGY-ANIYVTQPRRISAISVAERVARERCEQ-----LGDTVGYSVRFESVFPRPYGA- 481
            :.:.:|.... .::.|||||||||:|:|.||::|...:     :....||.:|.|:   |...|
Zfish   614 ELLAAGDTAQPCSVVVTQPRRISAMSLACRVSQELGSEDGPGSMNSLCGYQIRMEN---RSSEAT 675

  Fly   482 -ILFCTVGVLLRKLEAG--LRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATID 543
             :|:||.|||||||:..  |..::||||||:|||.|.|||||.||:::|....||.:||||||:|
Zfish   676 RLLYCTTGVLLRKLQQDRHLNSLTHIIVDEVHERSVQSDFLLTILKEVVHKRADLRLILMSATVD 740

  Fly   544 TTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQL---LSEDKD 605
            ..||:.||..|||:.:|||.|||:.|.||||::.|.:|...:|...:|.||:||::   ::: |.
Zfish   741 CQKFANYFNRCPVVSIPGRTFPVEVFHLEDIVEETGYVLEQDSEYSQKFVEEEEEVNIGITQ-KG 804

  Fly   606 EAEINYNKVCE-------------DKYSQKTRNAMAMLSESDVSFELLEALLMHI-KSKN---IP 653
            ...:.:.::..             |.:|.:||:.:..::.:.::.:|:..||.:: ||..   :.
Zfish   805 GKTVQHQELIVRDSASGWDLGPELDHFSSRTRHILQYMNPNKINMDLILDLLAYLDKSPQFNAVD 869

  Fly   654 GAILVFLPGWNLIFALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTN 718
            ||:||||||...|..|...|.....|....:|:::..||.:...:|...|...|.||.||:||||
Zfish   870 GAVLVFLPGLAHIQQLHDLLSTDKRFSSKDRYKLVALHSSLSSQDQSSAFTVPPAGVRKIVLSTN 934

  Fly   719 IAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSR 783
            ||||.:||.|:|||||..:.:...:...:.::|...::.||.:..||:|||||||.||||.|..:
Zfish   935 IAETGVTIPDVVFVIDTGRTKENRYHESSQMSSLVEMFVSKASALQRQGRAGRVREGFCFRLYPK 999

  Fly   784 ARFQALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVDAVIEAEVLLREM-RCLD 847
            .||::..|...||:.|.||.|:.|.|.....||...|||::|:.|...||..|..|||.: .|..
Zfish  1000 FRFESFIDYSIPEILRVPLEELCLHIMKCEYGSPEDFLSRSLDAPQQQAVCNAVSLLRRIGACQQ 1064

  Fly   848 ANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEVFSLDIGQRRLANHQK 912
            ....|||||..||.||:..::|||::.||:|||.:.:|.:|:..|..|. |:..:.::..||..|
Zfish  1065 DTHTLTPLGHHLAALPVNVKIGKMLIFGAIFGCLEPIATIAAAMSEKSP-FATPMSRKEEANLAK 1128

  Fly   913 ALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFP 977
            :......|||:.:..|...||..:..|...|..:|....|..:.:..|.:.||:|:.:::||||
Zfish  1129 SALAVANSDHMTIYKAYLGWRSSRTEGTRAEMNYCRRHFLNRTALITIEEVKQELMRMVEQAGF- 1192

  Fly   978 EECMISHEVDERIDGDDP----------VLDVSLALLCL-------GLY---------PNICVHK 1016
                    |..:: |..|          .|.:|...:|:       |||         |::.|.:
Zfish  1193 --------VSSKL-GRTPRPRPSTETKAPLSISTQDVCVVKATLTAGLYDNVGRILYSPSLDVQE 1248

  Fly  1017 EKRKVLTTESKAALLHKTSVNCSNLAVTFPYPFFVFGEKIRTRAVSCKQLSMVSPLQVILFGSRK 1081
            ....|:.|....|.:|.:|||    .....:.:.:|.||::...|..|..:::|||.::|||. .
Zfish  1249 RVVCVVETAQGKAHVHPSSVN----RFLQTHGWMLFQEKVKYSKVFLKDTTLISPLSMLLFGG-D 1308

  Fly  1082 IDLA-ANNIVRVDNWLNFDIEPELAAKIGALKPALEDLITVACDNPSDILRLEEPYAQLVKVVK 1144
            ||:. ...::.:|.|:.|.....:......|:..::.|:.....||...|..|:....:::::|
Zfish  1309 IDVQHRERLISLDGWICFQAPVRIGVIFKHLRKLIDSLLERKLANPKMNLEDEKTIQIIIELIK 1372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683	14/61 (23%)
		DSRM_DHX9_rpt2	167..241	CDD:380684	23/128 (18%)
		DEXHc_DHX9	326..559	CDD:350730	97/249 (39%)
		HrpA	378..>889	CDD:441249	213/541 (39%)
		OB_NTP_bind	1002..1079	CDD:400182	23/92 (25%)
dhx29	XP_697933.6	HrpA	573..>1191	CDD:441249	233/622 (37%)
		DEXHc_DHX29	574..756	CDD:350733	84/184 (46%)
		OB_NTP_bind	1223..1309	CDD:400182	23/90 (26%)