Protein Alignment mle and tdrd9

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: XP_068068947.1
• Gene: tdrd9 / 553222
• ZFINID: ZDB-GENE-090313-193
• Length: 1344
• Species: Danio rerio
• Alignment Length: 821
• Identity: 253/821 - (30%)
• Similarity: 394/821 - (47%)
• Gaps: 161/821 - (19%)

  Fly   308 SRIDSSQQ----DGEKRQESSVIPWAPPQANWNTWHACNIDEGELATTSIDDLSMDYERSLRDRR 368
            |.:.|.::    ||.:|::.:.:|..|                   .||...|: .||..:
Zfish    48 SELSSPEKEKSDDGNQRRKRAQLPTGP-------------------GTSPPSLA-SYEYPI---- 88

  Fly   369 QNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYI-----CS 428
                           |||...|.|:::.|.:|.||||||.||.|||||:.|:|||.|.     |
Zfish    89 ---------------LPITKNRQELVSLIENNSVVIIRGATGSGKTTQLPQFILDHYAERNIPC- 137

  Fly   429 GQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRK 493
                  |:.|||||:|.|.|:|..|||||...||..|||.|..|.: ...:..:::.|.||||:|
Zfish   138 ------NLVVTQPRKIGATSIARWVARERKCTLGSLVGYQVGLEKM-ATEHTKLIYVTTGVLLQK 195

  Fly   494 LEAG--LRGVSHIIVDEIHERDVNSDFLLVILRDMV---DTYPDLHVILMSATIDTTKFSKYFG- 552
            |.:.  |...|||.:||:|||....||||:::|.::   ..|  :.||||||||:..:|::|||
Zfish   196 LVSSKTLTEYSHIFIDEVHERSEELDFLLLVVRKLLRSNSRY--VKVILMSATINCIEFAEYFGS 258

  Fly   553 -----ICP--VLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEIN 610
                 :.|  |.||.|..:.|::::|:::..|   :|...:.         :..|.:|....|..
Zfish   259 PIRNQMNPAYVFEVEGAPYAVEEYYLDELKTM---LPVGVNL---------DLTLPQDPYITEEM 311

  Fly   611 YNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIK------SKNIP--GAILVFLPGWNLI- 666
            ||.            |::::.    ||:.:||.....:      |...|  |::||||||...|
Zfish   312 YNV------------AVSLIQ----SFDEMEAKDHRSRRSEQTGSTTHPERGSVLVFLPGLAEIQ 360

  Fly   667 ---FALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRKVF-EPVPEGVTKIILSTNIAETSITID 727
               .||.|.::        .:.|:.|.||.:..:||..|| .||| |..||||||||||:|:|:.
Zfish   361 YMKEALSKLVR--------KRLQVYPLHSTVTLEEQNGVFLVPVP-GYRKIILSTNIAESSVTVP 416

  Fly   728 DIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDN 792
            |:.:|||.|..|........|.......|||||:..||:||||||..|||:.|.:|..::....|
Zfish   417 DVKYVIDFCLVRQLACDKETNYRCLRITWASKTSCNQRRGRAGRVSKGFCYRLVTRHFWENEIPN 481

  Fly   793 LT-PEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVDAVIEAEVLLREMRCLDA-------- 848
            .: |||.|:||....|.:|||.:|.....||.||.||.:..:....:.|:::..|..
Zfish   482 FSIPEMLRSPLASTLLKVKLLDMGDPRSVLSTALTPPILGDIERTVLQLKQIGALSVQSNSQRQF 546

  Fly   849 NDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEVFSLDIGQRRLANHQKA 913
            :.:||.|||:||:||::.:|||::|||.||||.:...|:|: |.:....|::. ..::||.::..
Zfish   547 DGDLTFLGRVLAQLPVDLQLGKLIVLGHVFGCLEECLIIAA-SLSLKSFFAMP-SLQQLAGYRSK 609

  Fly   914 LSGTK--CSDHVAMIVASQMWRREKQRGE--HMEARFCDWKGLQMSTMNVIWDAKQQLLDL---- 970
            ||..:  .||.:|.:.|.:.|...:.:||  |.:... :|.......:..|.:..:...||
Zfish   610 LSFAQNVPSDFIAYVNAFKAWYTSRAKGELRHPKDEL-EWGKENCIQIKRIREVAELFEDLKKRV 673

  Fly   971 ------LQQAGFPEECMISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKEKRKVLTTESKAA 1029
                  :..:..|.:....|:  :|.     :|.|.:|   ..|:||.....|..:.|.::..:.
Zfish   674 SRFNMHISSSSNPTDYTSLHK--QRF-----ILQVVIA---GALFPNYFSQGEIDEQLASKELSG 728

  Fly  1030 LLHKTSVNCSNLAVTFPYPFFVFGEKIRTRAVSCKQLSMVS 1070
            ...||::...||.   |:.|..: :::::....|.|:..::
Zfish   729 NDPKTTILIRNLP---PFAFLCY-KQLQSLFRQCGQVKSIA 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684
		DEXHc_DHX9	326..559	CDD:350730	91/250 (36%)
		HrpA	378..>889	CDD:441249	203/550 (37%)
		OB_NTP_bind	1002..1079	CDD:400182	14/69 (20%)
tdrd9	XP_068068947.1	HrpA	87..>694	CDD:441249	223/675 (33%)
		DEXHc_TDRD9	89..272	CDD:350746	84/192 (44%)
		Tudor_TDRD9	864..965	CDD:410502