DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mle and dhx33

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	XP_002932324.1	Gene:	dhx33 / 447985	XenbaseID:	XB-GENE-949473	Length:	678	Species:	Xenopus tropicalis

Alignment Length:	716	Identity:	209/716 - (29%)
Similarity:	330/716 - (46%)	Gaps:	116/716 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   379 EFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRR 443
            |.|..|||...||:|:..:.....|:|.|.||.||||||.||:.:..|    |..:.|.||||||
Frog    40 EQRRSLPIYLARSQIIAQLRKLDSVVIIGETGSGKTTQIPQYLYEASI----GRQSIIAVTQPRR 100

  Fly   444 ISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRKL--EAGLRGVSHIIV 506
            ::|||:|.||:.||..:|...|||:||||.|.... ..|.|.|.|:|||:.  :..||..|.:|:
Frog   101 VAAISLATRVSEERRTELSKLVGYTVRFEDVTSEE-TKIKFLTDGMLLREAIGDPLLRKYSVVIL 164

  Fly   507 DEIHERDVNSDFLLVIL------RDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFP 565
            ||.|||.:::|.|..::      |...:..| |.:|:||||:|...||:||...|||.:.||..|
Frog   165 DEAHERTIHTDVLFGVVKSAQKKRKEQEKQP-LKIIIMSATMDVDLFSEYFNGAPVLYLEGRQHP 228

  Fly   566 VQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAML 630
            :|.|:.::  ..:|::.:|
Frog   229 IQIFYTKE--SQSDYLQAA---------------------------------------------- 245

  Fly   631 SESDVSFELLEALLMHIKSKNIPGA--ILVFLPGWNLIFALMKFLQ--NTNIFGDTSQYQILPCH 691
                    |:....:|   :.:|.:  |||||.|...|.|:.|..:  :.::..|..:..::|.:
Frog   246 --------LVTVFQVH---QEVPASHDILVFLTGQEEIEAMTKTCRDISKHLPDDCPKMVVMPLY 299

  Fly   692 SQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVW 756
            :.:|..:|.:||:..|:|..|:|||||||||||||..|.:|:|....:.|.:...:.|...|...
Frog   300 ASLPHSQQLRVFQNAPKGQRKVILSTNIAETSITIPGIKYVVDTGMVKAKKYNPESGLEVLAVQK 364

  Fly   757 ASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLLRLGSIH--H 819
            .||....||.|||||...|.|:.|.....|:..|:...||:.|..|..:.|.:.:||:.::|  .
Frog   365 VSKAQAWQRTGRAGREDSGICYRLYKEEEFEKFEEMTVPEIQRCNLASVMLQLLVLRVPNVHTFD 429

  Fly   820 FLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLM 884
            |:||. .|..:.|.|:...||..:........|||||:.:|..|:||:..|.::|...|.|.:.:
Frog   430 FMSKP-SPDSIQAAIDQLHLLGAVERKGDQIVLTPLGKKMAAFPLEPKFSKTILLSPKFHCTEEI 493

  Fly   885 AIMASYSSTFSEVFSLDIGQRRL-ANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCD 948
            ..:.|..|..|.:.:....:..: |..:|.:|..  .||:.::   .::|..|..|::.:  :|.
Frog   494 LTIVSLLSVDSVLHNPASKRDEVQAARKKFISSE--GDHITLL---NIYRAFKNLGKNKD--WCR 551

  Fly   949 WKGLQMSTMNVIWDAKQQLLDLLQQAGFPEE-----------C----MISHEVDERIDGDDPVLD 998
            ...:....|.::.:.:.||.|:..:...|.|           |    :..|..:.:.||....:|
Frog   552 ENFINGRNMTMVLEVRSQLRDICIKLSMPMESSRTDTRNIRQCLAHGLFMHAAELQPDGTYTTVD 616

  Fly   999 VSLALLCLGLYP-NICVHKEKRKVLTTESKAALLHKTSVNCSNLAVT-----FPYPFFVFGEKIR 1057
            ....   :.::| :|..|.:...|:..|    |||.:.....:|.|.     |......|..|:|
Frog   617 THQP---IAIHPSSILFHCKPACVVYNE----LLHTSKCYMRDLCVVDADWLFEAAPDYFRRKLR 674

  Fly  1058 T 1058
            |
Frog   675 T 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634
		DEXDc	393..569	CDD:214692	78/183 (43%)
		DEXDc	402..542	CDD:238005	64/147 (44%)
		ATP-synt_B	<584..644	CDD:304375	2/59 (3%)
		Helicase_C	643..772	CDD:278689	47/132 (36%)
		HA2	842..926	CDD:214852	21/84 (25%)
		OB_NTP_bind	974..1078	CDD:285018	22/106 (21%)
dhx33	XP_002932324.1	HrpA	38..667	CDD:224557	205/706 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910