DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and dhx38

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	NP_957170.1	Gene:	dhx38 / 393850	ZFINID:	ZDB-GENE-040426-1144	Length:	1258	Species:	Danio rerio

Alignment Length:	1037	Identity:	261/1037 - (25%)
Similarity:	442/1037 - (42%)	Gaps:	269/1037 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 NDVPADAGASGGGPRTGLEGAGMAGGSGQQKRVFDGQSGPQDLGEAYRPLNHDGGDGGNRYSVID 141
            |:...|....|..||       ::.|.|:::                     :.|:||.::...|
Zfish   303 NEWANDRKHFGSTPR-------LSRGKGEKR---------------------EEGEGGIQFDDED 339

  Fly   142 -RIQEQRDMNEA--------EAFDVNAAIHGNWTI---ENAKERLNIYKQTNNIRDDYKYTPVGP 194
             :.|.:.|..:|        |.:|   ..|...|.   |..|:|..|.::....|...:...:..
Zfish   340 EKEQWEEDQRQADRDWYMMDEGYD---EFHNPLTSSSDEYVKKREQILQKQTQKRISAQKRQINE 401

  Fly   195 EHARSFLAELSIYVPALNRTVTAR-------ESGSNKKSASKSCALSLVRQLFHLNVIEPF-SGT 251
            ::.|.          ..||.:|:.       :....:.:|::      |..|.| |::.|| .|.
Zfish   402 DNERW----------ETNRMLTSGVVQRLEVDEDFEEDNAAR------VHLLVH-NLVPPFLDGR 449

  Fly   252 LKKKKDEQLKP-YPVKLSPNLINKIDEVIKGLDLPVVNPRNIKIELDGPPIPLIVNLSRIDSSQQ 315
            :...|  |.:| .|||.:.:            |:.:::.:..:             |.|....|:
Zfish   450 IVFTK--QPEPVIPVKDATS------------DMAIISRKGSQ-------------LVRRHREQK 487

  Fly   316 DGEKRQESSVIPWAPPQANWNTWHACNIDEGELATTSIDDL-------------------SMDY- 360
            :.:|.|..          :|           |||.|.:.|:                   .:||
Zfish   488 ERKKAQHK----------HW-----------ELAGTKLGDIMGIQKKEDGGDSKAVGEDGKVDYR 531

  Fly   361 -ERSLRDRRQNDNE-------YRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQI 417
             |:...|..:..:|       .:..||.|:.|||.|:|.::|..|.||.:||:.|.||.|||||:
Zfish   532 AEQKFADHMKEKSEASSDFAKKKTLLEQRQYLPIFAVRQQLLNIIRDNNIVIVVGETGSGKTTQL 596

  Fly   418 AQYILDDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAI 482
            .||:.:|    |...|..:..|||||::|:|||:||:.|....||:.|||::|||...... ..|
Zfish   597 TQYLHED----GYTSYGMVGCTQPRRVAAMSVAKRVSEEMNSNLGEEVGYAIRFEDCTSEK-TMI 656

  Fly   483 LFCTVGVLLRK--LEAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTT 545
            .:.|.|:|||:  .|:.|...|.:|:||.|||.:|:|.|..:||::|....||.:|:.|||:|:.
Zfish   657 KYMTDGILLRESLRESDLDHYSAVIMDEAHERSLNTDVLFGLLREVVSRRSDLKLIVTSATMDSD 721

  Fly   546 KFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEIN 610
            ||:.:||..|:..:|||.|||                                         :|.
Zfish   722 KFASFFGNVPIFHIPGRTFPV-----------------------------------------DIL 745

  Fly   611 YNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGW-------NLIFA 668
            ::|..::.|               |...:.:||.:|:  ..:.|.||:|:||.       :.|..
Zfish   746 FSKTPQEDY---------------VEAAVKQALQIHL--SGMVGDILIFMPGQEDIEVTSDQIVE 793

  Fly   669 LMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVI 733
            .:..|:|.....      :||.:||:|.|.|.|:|:..|:||.|.|::|||||||:|:|.|:||:
Zfish   794 RLADLENAPALA------VLPIYSQLPSDLQAKIFQKAPDGVRKCIVATNIAETSLTVDGIMFVV 852

  Fly   734 DICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLT---P 795
            |....::|:|.....:.:......|:.|..||.|||||..||.|:.|.:::.|:  .:.||   |
Zfish   853 DSGYCKLKVFNPRIGMDALQVYPISQANANQRAGRAGRTGPGQCYRLYTQSAFK--NEMLTTTIP 915

  Fly   796 EMFRTPLHEMALTIKLLRLGS--IHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRL 858
            |:.||.|..:.|.:|.|.:..  :.||    ::|||.|.::.:...|..:..||....|||.|||
Zfish   916 EIQRTNLANVVLLLKSLGVQDLLLFHF----MDPPPEDNMLNSMYQLWILGALDNTGALTPTGRL 976

  Fly   859 LARLPIEPRLGKMMVLGAVFGC-ADLMAIMASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDH 922
            :...|::|.|.||:::.....| ||::.|::..|  ...:|....|:...::..:.......|||
Zfish   977 MVEFPLDPALSKMLIVSCDMSCSADILIIVSMLS--VPSIFYRPKGREEESDQVREKFSVPESDH 1039

  Fly   923 VAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFP---------- 977
            :..:.....|     :..:..:.:|:...:....|..:.:.:.||.|::.|....
Zfish  1040 LTYLNVYLQW-----KNNNYSSIWCNDHFIHTKAMRKVREVRAQLKDIMVQQKMNLISCGSDWDV 1099

  Fly   978 -EECMIS---HEVDERIDGDDPVLDVSLALLC----------LGLYPNICVHKEKRKVLTTE 1025
             .:|:.:   |:. .::.|....::|...:.|          :|..|:..::.|  .|:||:
Zfish  1100 IRKCICAAYFHQA-AKLKGIGEYVNVRTGMPCHLHPTSALFGMGYTPDYIIYHE--LVMTTK 1158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634	10/76 (13%)
		DEXDc	393..569	CDD:214692	78/177 (44%)
		DEXDc	402..542	CDD:238005	61/141 (43%)
		ATP-synt_B	<584..644	CDD:304375	5/59 (8%)
		Helicase_C	643..772	CDD:278689	48/135 (36%)
		HA2	842..926	CDD:214852	23/84 (27%)
		OB_NTP_bind	974..1078	CDD:285018	11/76 (14%)
dhx38	NP_957170.1	DEXDc	557..744	CDD:214692	86/232 (37%)
		DEXDc	580..718	CDD:238005	61/142 (43%)
		HELICc	793..892	CDD:197757	40/104 (38%)
		HA2	961..1043	CDD:214852	23/83 (28%)
		OB_NTP_bind	1077..1177	CDD:285018	15/85 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910