DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mle and Dhx30

DIOPT Version :9

Sequence 1:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster
Sequence 2:	XP_006243888.1	Gene:	Dhx30 / 367172	RGDID:	1308888	Length:	1222	Species:	Rattus norvegicus

Alignment Length:	1276	Identity:	357/1276 - (27%)
Similarity:	576/1276 - (45%)	Gaps:	301/1276 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 IRQTGPKNRQ-----RFLCEVRVEPNTYIGVGNSTNKKDAEKN----ACRDFVNYLVRVGKLNTN 77
            :...|||.::     ::...|.||       |..:.|.|||:.    ||:.|..:    |.|
  Rat   105 VHTNGPKKKKVTLHIKWPKSVEVE-------GYGSKKIDAERQAAAAACQLFKGW----GLL--- 155

  Fly    78 DVPADAGASGGGPRTGLEGAGMAGGSGQQKRVFDGQSG-PQDL---------GEAYRPLNHD--- 129
                       |||..|..|.       :.||...:.| |.|.         ..::|.||.:
  Rat   156 -----------GPRNELFDAA-------KYRVLADRFGSPADSWWRPEPTMPPTSWRQLNPENIR 202

  Fly   130 -GGDGGNRYSVIDRIQEQRDMNEAEAFDVNAAIHGNWTIENAKERL------------------- 174
             .|.||...| :.|.:|:.:..|.|...::.....:.|.:::...|
  Rat   203 PAGTGGLSRS-LGREEEEDEEEELEEGTIDVTEFLSMTQQDSHNPLRDSRGGSFEMTDDDSAIRA 266

  Fly   175 ---------------NIYKQTNNIRDDYKYTPVGPEHARSFLAELSIYVPALNRTVTARESGSNK 224
                           .|...::..::..::..||   .::.||.|::..|.   .:|....|..|
  Rat   267 LTQFPLPKNLLAKVIQIATSSSTAKNLMQFHTVG---TKTKLATLTLLWPC---PMTFVAKGRRK 325

  Fly   225 KSASKSCALSLVRQLFHLNVI----EPFS------GTLKKKKDEQLKPYPVKLSPNLINKIDEVI 279
            ..|....|....::|..|.::    ||.:      .:|::..:.|.:|..:::...::.||:..:
  Rat   326 AEAENKAAALACKKLKSLGLVDRNNEPLTHAMYNLASLRELGETQRRPCTIQVPEPILRKIEAFL 390

  Fly   280 K--GLDLPVVNPRNIKIELDGPPIPLIVNLSRIDSSQQDGEKRQESSVIPWAPPQANWNTWHACN 342
            .  .:|...::| .::::.| ..:||         .:..|......:..|:.|
  Rat   391 SHYPVDSSWISP-ELRLQSD-DILPL---------GKDSGPLSDPITGKPYMP------------ 432

  Fly   343 IDEGELATTSIDDLSMDYERSLRD--RRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVII 405
            :.|.|....|         :||.:  ||:.     ...:...:||:...|..||:||..:|||:|
  Rat   433 LSEAEEVRLS---------QSLLELWRRRG-----PIWQEAPQLPVDPHRDTILSAIEQHPVVVI 483

  Fly   406 RGNTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVR 470
            .|:|||||||:|.|.:|:.|:..|:|...|:.:||||||||:|||:||:.|....|...||:.||
  Rat   484 SGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVGFQVR 548

  Fly   471 FESVFPRPYGAILFCTVGVLLRKLEA--GLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDL 533
            .||..|...||:||||||:|||||::  .|.||||:||||:||||||:||||::|:.:....|.|
  Rat   549 LESKPPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPAL 613

  Fly   534 HVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQ 598
            .::|||||.|..:||:|||.|||::|||..:||::.:||||:.
  Rat   614 RLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDILA---------------------- 656

  Fly   599 LLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGW 663
                          |:.:.:|..:.|:..:. .|..:..:|:..|::||.::..||.||.|||||
  Rat   657 --------------KLGKHQYPHRHRHHESE-DECALDLDLVTDLVLHIDARGEPGGILCFLPGW 706

  Fly   664 NLIFALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDD 728
            ..|..:.:.||.. :....|:|.|||.||.||..:|:.:|:..|.||.||:|:|||||||||::|
  Rat   707 QEIKGVQQRLQEA-LGMHESKYLILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAETSITVND 770

  Fly   729 IVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNL 793
            ||.|:|....:.:.:.....::...|||.|:.|:.||:|||||.:.||.:.|..|:|.:.:....
  Rat   771 IVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQ 835

  Fly   794 TPEMFRTPLHEMALTIKLLRLGSIH-------HFLSKALEPPPVDAVIEAEVLLREMRCLDANDE 851
            .||:.||||..:.|..|      ||       .|||||::.|.:.||.||.:||:|:..||..:.
  Rat   836 VPEILRTPLENLVLQAK------IHMPEKTAVEFLSKAVDSPNIKAVDEAVILLQEIGVLDQREY 894

  Fly   852 LTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEVFSLDIGQRRLANHQKA-LS 915
            ||.||:.||.:..:|||.|.:||.|:|.|  |..::...|....:.||..:..|...:..|| ||
  Rat   895 LTTLGQRLAHISTDPRLAKAIVLAAIFRC--LHPLLVVVSCLTRDPFSSSLQNRAEVDKVKALLS 957

  Fly   916 GTKCSDHVAMIVASQ------MWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQA 974
            ....|||:|.:.|..      .|:....|..::|...     |...::..|....:|..:.:.:|
  Rat   958 HDSGSDHLAFVRAVAGWEEVLRWQDRTSRENYLEENL-----LYAPSLRFIHGLIKQFSENIYEA 1017

  Fly   975 ---GFPEECMI-SHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKEKRKV------------LT 1023
               |.|.:|.: |.:.:|..:.::.|..|.:|    |||||: :...:.||            ..
  Rat  1018 FLVGKPSDCTLPSAQCNEYSEEEELVKGVLMA----GLYPNL-IQVRQGKVTRQGKFKPNSVTYR 1077

  Fly  1024 TESKAALLHKTSVNCSNLAVTFPYPFFVFGEKIRTR------------AVSCKQLSMVSPLQVIL 1076
            |:|...||||:::|..             ..::|:|            :|..:..|.|.||.|:|
  Rat  1078 TKSGNILLHKSTINRE-------------ATRLRSRWLTYFMAVKSNGSVFVRDSSQVHPLAVLL 1129

  Fly  1077 F----------GSR-KIDLAANNIVRVD-------------NWLNFDIEPELAAKIGALKPALED 1117
            .          |.| .|.|:.::::|::             ..|...:|..|.:::.||.
  Rat  1130 LTDGDVHIRDDGRRATISLSDSDLLRLEGDSRTVRLLRELRRALGRMVERSLRSELAALP----- 1189

  Fly  1118 LITVACDNPSDILRLEEPYAQLVKVVKDLCVKSAGDFGLQR 1158
                        |.:::.:.||:.::.:|.....|.|.:::
  Rat  1190 ------------LSVQQEHGQLLALLAELLRGPCGSFDVRK 1218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM	4..68	CDD:214634	14/54 (26%)
		DSRM	170..240	CDD:214634	13/103 (13%)
		DEXDc	393..569	CDD:214692	99/177 (56%)
		DEXDc	402..542	CDD:238005	79/141 (56%)
		ATP-synt_B	<584..644	CDD:304375	5/59 (8%)
		Helicase_C	643..772	CDD:278689	57/128 (45%)
		HA2	842..926	CDD:214852	31/84 (37%)
		OB_NTP_bind	974..1078	CDD:285018	32/141 (23%)
Dhx30	XP_006243888.1	DEXDc	466..645	CDD:214692	98/178 (55%)
		DEXDc	480..621	CDD:238005	78/140 (56%)
		HELICc	714..813	CDD:197757	43/99 (43%)
		HA2	885..968	CDD:214852	31/84 (37%)
		OB_NTP_bind	1008..1130	CDD:285018	32/139 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820