Protein Alignment mle and Dhx57

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: NP_001178836.1
• Gene: Dhx57 / 366532
• RGDID: 1310340
• Length: 1391
• Species: Rattus norvegicus
• Alignment Length: 1406
• Identity: 400/1406 - (28%)
• Similarity: 595/1406 - (42%)
• Gaps: 375/1406 - (26%)

  Fly    70 RVGKLNTNDVPADAGASGGGPRTGLEGAGMAGGSGQQK---RVFD-------------------- 111
            |.|:.:.|......|:.|||.     |.|..||||.:|   |::|
  Rat    24 RGGRGHVNKSHGGGGSGGGGC-----GGGGGGGSGSRKASNRIWDDGDDFCVFTESKRPSRPCDS 83

  Fly   112 ----GQSGP--------------------QDLGEAYRPLNHDGGDGGNRYSVIDRIQEQRDMNEA 152
                |::.|                    :.:....|.|...|.|.|:         |:....|.
  Rat    84 NKSKGETRPKWKPKAKVPLQTLHMTSENQEKVKALLRDLQEQGADAGS---------ERGSSGEE 139

  Fly   153 EAFDVNAAIHGNWTIENAKERLNIYKQTNNIRDDYKYTPVGPEHARSFLAELSIYVPALNRTVTA 217
            |......|...:|:..         .:...:.|...:..:|||.....|.|.::...|:.:....
  Rat   140 EEDAPEGAAEQSWSAG---------PEPTFLPDCRPWEYIGPEEVEPPLPEFTVSPLAVQKLSRY 195

  Fly   218 RESGSNKKSASKSCALSLVRQLFHLNVIEPFSGT-------------------LKKKKDEQLKPY 263
            .....:.:.|.:.|...|...|.|| :.:.||.|                   ::::::|.|...
  Rat   196 GFHTEHCQLALRICEGDLGAALEHL-LHQCFSETFGERMALSEAAVSVSLDECVEQRQEETLALK 259

  Fly   264 PV---KLSPNLINKIDEVIKGLDLPVV-------------------NPRNIKIELDG-------- 298
            .:   |....:.|::..:  ||:|..:                   :|...|..|.|
  Rat   260 SICGEKFIERIQNRVWTI--GLELEYLTNKFCKSKQKESNKNVRDTSPETCKFYLKGNCKFGSKC 322

  Fly   299 ------PPIPLIVNLSR-IDSSQQDGEK------------------------------------- 319
                  ||..:|....| ::....|.|.
  Rat   323 KFKHEVPPHQIIGRTERNVNDPHLDAENDTTFLYELQIRFSKDHKYPYQAPLVAFYSTNENLPLA 387

  Fly   320 -------------------------------RQESSV-----------------IPWAP------ 330
                                           .:||.:                 :|.||
  Rat   388 CRLHISEFLYGKALEFAKTSEPVVYSLITLLEEESEIVKLLTHTQHKYSVPPINVPPAPSETRIS 452

  Fly   331 ------PQANWNTWHACNIDEGELATTSIDDLSMD----------------YERSLR--DR---- 367
                  |....||:.:..:.|||..:...:|...|                .:||.|  ||
  Rat   453 KPAYRKPVIPSNTFLSNQMLEGEGLSELEEDADEDEGPAPIVVENESYVNLKKRSYRRCDRPAKS 517

  Fly   368 --------------RQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIA 418
                          :|...::...|:.|:.||....|..||..::.:.||:|.|.|||||||||.
  Rat   518 LFAENSKICRQFQMKQASRQFHAILQERQLLPAWEERETILKLLSKHQVVVISGMTGCGKTTQIP 582

  Fly   419 QYILDDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAIL 483
            |:|||:.:.......|||..||||||||||||||||:||.|::|.||||.:|.||| ......:|
  Rat   583 QFILDNSLNGPPERVANIICTQPRRISAISVAERVAKERAERVGLTVGYQIRLESV-KSSATRLL 646

  Fly   484 FCTVGVLLRKLE--AGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTK 546
            :||.|||||:||  |.|:||:||||||:|||...|||||::|:|:|.....|.|||||||:|...
  Rat   647 YCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQRATLQVILMSATLDAGL 711

  Fly   547 FSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFV-------------------PSAESRRKRKE 592
            |||||..|||:.:|||||||.||||||.:.:|.:|                   .:..:|...:|
  Rat   712 FSKYFSYCPVITIPGRAFPVDQFFLEDALAVTRYVLQDGSPYMRSMKQIAKERLKARHNRTALEE 776

  Fly   593 VEDEEQLLSEDKDEAE-----------------INYNKVCEDKYSQKTRNAMAMLSESDVSFELL 640
            ||::.:|....:||.|                 :.|..|     |:.....|:::....|:.||:
  Rat   777 VEEDLRLALHLQDEEESVKDTIPDQQLDFKQLLVRYKGV-----SKSVIKTMSVMDFEKVNLELI 836

  Fly   641 EALLMHI---KSKNIPGAILVFLPGWNLIFALMKFLQNTNIFGDTSQYQ--ILPCHSQIPRDEQR 700
            ||||..|   |....||||||||||...|..|.:.||:.::|.:...::  |.|.||.:..:||:
  Rat   837 EALLEWIVDGKHSYPPGAILVFLPGLAEIKMLYEQLQSNSLFNNRRSHRCVIHPLHSSLSSEEQQ 901

  Fly   701 KVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQR 765
            .||...|.||||||:|||||||||||||:|:|||..|.:.|.:.:...:.|....:.|:.|..||
  Rat   902 AVFVKPPLGVTKIIISTNIAETSITIDDVVYVIDSGKMKEKRYDAGKGMESLEDTFVSQANALQR 966

  Fly   766 KGRAGRVRPGFCFTLCSRARF--QALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHF---LSKAL 825
            |||||||..|.||.|.:...:  |.|:..| ||:.|.||.::.|.||:|.:.|.|:.   .|:.:
  Rat   967 KGRAGRVASGVCFHLFTSHHYNHQLLKQQL-PEIQRVPLEQLCLRIKILEMFSTHNLQSVFSRLI 1030

  Fly   826 EPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASY 890
            |||.||::..::|.||::..|..:::|||||..||.||::.|:||:|:||::|.|.| .|:..:.
  Rat  1031 EPPHVDSLRASKVRLRDLGALTPDEKLTPLGYHLASLPVDVRIGKLMLLGSIFRCLD-PALTIAA 1094

  Fly   891 SSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMS 955
            |..|...|.....::..||.:|.......||::|::.|.:.|:...:........:|....|...
  Rat  1095 SLAFKSPFVSPWDKKEEANQKKLEFAFANSDYLALLCAYKGWQLSTKESARASYNYCRQNFLSGR 1159

  Fly   956 TMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVS--------------LALLCL 1006
            |:..:...|:|..:||...||.:|.:.:.|:::|..|.|.|||.:              .|:||.
  Rat  1160 TLQEMASLKRQFTELLSDIGFVKEGLRAKEIEKRAQGGDGVLDATGEEANTNAENPKLISAVLCA 1224

  Fly  1007 GLYPNIC--------VHKEKRKVLTTESKAALL------------HKTSVNCSNLAVTFPYPFFV 1051
            .||||:.        ..|....|:..:.|:|.|            |.:|||..  ...|..|:.:
  Rat  1225 ALYPNVVQVKTPEGKFQKTSSGVVRLQPKSAELKFVTKNDGYVHIHPSSVNYQ--VRHFDSPYLL 1287

  Fly  1052 FGEKIRTRAVSCKQLSMVSPLQVILFGSRKIDLAANN---IVRVDN-WLNF-DIEPELAAKIGAL 1111
            :.|||:|..|..:..||||...::|||..::.:....   :|.:|: |:.| ....::|..:..|
  Rat  1288 YHEKIKTSRVFIRDCSMVSVYPLVLFGGGQVSVQLQRGAFVVSLDDGWIRFVAASHQVAELVKEL 1352

  Fly  1112 KPALEDLITVACDNPSDILRLEEPYAQLVKVVKDLCVKSAG 1152
            :..|:.|:.....|||                .|||....|
  Rat  1353 RCELDQLLQDKIKNPS----------------MDLCTCPRG 1377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683	400/1406 (28%)
		DSRM_DHX9_rpt2	167..241	CDD:380684	11/73 (15%)
		DEXHc_DHX9	326..559	CDD:350730	120/282 (43%)
		HrpA	378..>889	CDD:441249	247/558 (44%)
		OB_NTP_bind	1002..1079	CDD:400182	29/96 (30%)
Dhx57	NP_001178836.1	UBA_DHX57	184..221	CDD:270502	7/37 (19%)
		RWD_DHX57	245..428	CDD:467661	19/184 (10%)
		zf_CCCH_4	308..326	CDD:465719	3/17 (18%)
		HrpA	548..>1175	CDD:441249	261/634 (41%)
		OB_NTP_bind	1218..1315	CDD:400182	29/98 (30%)