Protein Alignment mle and pea

DIOPT Version :10

• Sequence 1: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Sequence 2: NP_610928.1
• Gene: pea / 36561
• FlyBaseID: FBgn0086895
• Length: 1242
• Species: Drosophila melanogaster
• Alignment Length: 1012
• Identity: 262/1012 - (25%)
• Similarity: 435/1012 - (42%)
• Gaps: 225/1012 - (22%)

  Fly   117 QDLGEAYRPLNHDGGDGGNRYSVIDRIQEQRDMNEAEAFDVNAAIHGNWTIENAKERLNIYKQTN 181
            ||.|:...||:|...|.          :..||.|....|..:.::            ||:  |.|
  Fly   360 QDSGKDLNPLSHAPEDD----------ESLRDRNPDGPFSSSTSM------------LNL--QGN 400

  Fly   182 NIRDDYKYTPVGPEH-ARSFLAELSIYVPALNRTVTARESGSNKKSASKSCALSLVRQLFHLNVI 245
            .:.        |.|| :|..:..:|                |.::...|....|.|.....:...
  Fly   401 GME--------GDEHESRKRVTRIS----------------SPERWEIKQMISSGVLDRSEMPDF 441

  Fly   246 EPFSGTLKKKKDEQ-------LKPYPVKLSPNLINKIDEVIKGLDLPVVNPRNIKIELDGPPIPL 303
            :..:|.|.|.:|::       ::..|..||.:          |..|..::|..|....||.....
  Fly   442 DEETGLLPKDEDDEADIEIEIVEEEPPFLSGH----------GRALHDLSPVRIVKNPDGSLAQA 496

  Fly   304 IVNLSRIDSSQQDGEKRQESSVIPWAPPQANWNTWHACNIDEGELATTSIDDLSMDYERSLRDRR 368
            .:..|.:...:::.:..|....|...|...|.| |              ||.|..|..|||....
  Fly   497 AMMQSALSKERREQKMLQREQEIEAMPTSLNKN-W--------------IDPLPEDESRSLAANM 546

  Fly   369 Q-------NDNEYRQ-----------------FLEFREKLPIAAMRSEILTAINDNPVVIIRGNT 409
            :       ...|:::                 .:|.|:.|||..:|.:::.|:.||.::|:.|.|
  Fly   547 RGMAAAPPEVPEWKKHVIGGKKSSFGKKTDLTLVEQRQSLPIYKLRDDLIKAVTDNQILIVIGET 611

  Fly   410 GCGKTTQIAQYILDDYICSGQGGY---ANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRF 471
            |.||||||.||:       |:.|:   ..|..|||||::|:|||:|||.|...:||..|||::||
  Fly   612 GSGKTTQITQYL-------GECGFTARGKIGCTQPRRVAAMSVAKRVAEEYGCRLGQEVGYTIRF 669

  Fly   472 ESVFPRPYGAILFCTVGVLLRK--LEAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLH 534
            |.. ..|...|.:.|.|:|||:  :||.|:..|.|::||.|||.:::|.|..:|:..|...|:|.
  Fly   670 EDC-TSPETIIKYMTDGMLLRECLMEAELKSYSVIMLDEAHERTIHTDVLFGLLKTAVQKRPELK 733

  Fly   535 VILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQL 599
            :|:.|||:|..|||:||...|:..:|||.|||
  Fly   734 LIVTSATLDAVKFSQYFFKAPIFTIPGRTFPV--------------------------------- 765

  Fly   600 LSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPG-- 662
                    |:.|.|..|..|               :...|:..:.:|::..  ||.||:||.|
  Fly   766 --------EVLYTKEPETDY---------------LDASLITVMQIHLREP--PGDILLFLTGQE 805

  Fly   663 -----WNLIFALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAET 722
                 ..:::..||     ::..|..:..|||.:|.:|.:.|.::|:|.|.|..|::::||||||
  Fly   806 EIDTACEILYERMK-----SLGPDVPELIILPVYSALPSEMQTRIFDPAPAGSRKVVIATNIAET 865

  Fly   723 SITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQ 787
            |:|||.|.:|:|....:.|::.|...:.|......|:...:||.|||||..||..:.|.:.   :
  Fly   866 SLTIDGIFYVVDPGFVKQKVYNSKTGMDSLVVTPISQAAAKQRAGRAGRTGPGKTYRLYTE---R 927

  Fly   788 ALEDNL----TPEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVDAVIEAEVLLREMRCLDA 848
            |..|.:    .||:.||.|....|.:|.:.:..:.||  ..::.|||::::.|...|..:..||.
  Fly   928 AYRDEMLPTPVPEIQRTNLATTVLQLKTMGINDLLHF--DFMDAPPVESLVMALEQLHSLSALDD 990

  Fly   849 NDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEVFSLDIGQRRLANHQKA 913
            ...||.|||.:|..|:||.|.||:::.....|:|.:..:.|..|. ..||.....::.||:.:||
  Fly   991 EGLLTRLGRRMAEFPLEPNLSKMLIMSVALQCSDEILTIVSMLSV-QNVFYRPKDKQALADQKKA 1054

  Fly   914 LSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFPE 978
            .......||:.::.....|:..|     ....:|....:|:.|:....|.::|||.::.:
  Fly  1055 KFNQAEGDHLTLLAVYNSWKNNK-----FSNAWCYENFVQIRTLKRSQDVRKQLLGIMDR----- 1109

  Fly   979 ECMISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKEKRKVLTT--ESKAALLHKTSVNCSNL 1041
                 |::|....|.:.| .:..| :|.|.:.| ...|:.::...|  :|:...:|.:|
  Fly  1110 -----HKLDVVSAGKNSV-RIQKA-ICSGFFRN-AAKKDPQEGYRTLVDSQVVYIHPSS------ 1160

  Fly  1042 AVTFPYP-FFVFGEKIRTRAVSCKQLSMVSPLQVILF 1077
            |:....| :.::.|.::|.....::::.:.|..::.|
  Fly  1161 ALFNRQPEWVIYHELVQTTKEYMREVTTIDPKWLVEF 1197

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684	13/74 (18%)
		DEXHc_DHX9	326..559	CDD:350730	92/261 (35%)
		HrpA	378..>889	CDD:441249	172/526 (33%)
		OB_NTP_bind	1002..1079	CDD:400182	15/79 (19%)
pea	NP_610928.1	GH2-like_DHX8	7..74	CDD:409668
		S1_DHX8_helicase	285..363	CDD:240189	2/2 (100%)
		HrpA	578..>1203	CDD:441249	210/721 (29%)